The Virginia-Maryland College of Veterinary Medicine is a two-state, three-campus professional school operated by the land-grant universities of Virginia Tech in Blacksburg and the University of Maryland at College Park. In addition to the main campus installation at Virginia Tech, the College also operates the Avrum Gudelsky Veterinary Center at College Park, and the Marion duPont Scott Equine Medical Center in Leesburg.

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  • Tracks Magazine, Fall 2019 

    Unknown author (Virginia-Maryland College of Veterinary Medicine, 2019)
    Tracks Magazine is the flagship publication of the Virginia-Maryland College of Veterinary Medicine. In this issue: "What a difference a yearling makes."
  • A commercial porcine circovirus (PCV) type 2a-based vaccine reduces PCV2d viremia and shedding and prevents PCV2d transmission to naive pigs under experimental conditions 

    Opriessnig, Tanja; Xiao, Chao-Ting; Halbur, Patrick G.; Gerber, Priscilla F.; Matzinger, Shannon R.; Meng, Xiang-Jin (2017-01-05)
    Porcine circovirus type 2 (PCV2) vaccination has been effective in protecting pigs from clinical disease and today is used extensively. Recent studies in vaccinated populations indicate a major PCV2 genotype shift from the ...
  • Ambient and Dosed Exposure to Quaternary Ammonium Disinfectants Causes Neural Tube Defects in Rodents 

    Hrubec, Terry C.; Melin, Vanessa E.; Shea, Caroline S.; Ferguson, Elizabeth E.; Garofola, Craig; Repine, Claire M.; Chapman, Tyler W.; Patel, Hiral R.; Razvi, Reza M.; Sugrue, Jesse E.; Potineni, Haritha; Magnin-Bissel, Geraldine; Hunt, Patricia A. (2017-08-15)
    Background: Quaternary ammonium compounds are a large class of chemicals used for their antimicrobial and antistatic properties. Two common quaternary ammonium compounds, alkyldimethylbenzyl ammonium chloride (ADBAC) and ...
  • Modulation of gap junction-associated Cx43 in neural stem/progenitor cells following traumatic brain injury 

    Greer, Kisha; Chen, Jiang; Brickler, Thomas; Gourdie, Robert; Theus, Michelle H. (2017-09)
    Restoration of learning and memory deficits following traumatic brain injury (TBI) is attributed, in part, to enhanced neural stem/progenitor cell (NSPCs) function. Recent findings suggest gap junction (GJ)-associated ...
  • High-frequency irreversible electroporation is an effective tumor ablation strategy that induces immunologic cell death and promotes systemic anti-tumor immunity 

    Ringel-Scaia, Veronica M.; Beitel-White, Natalie; Lorenzo, Melvin F.; Brock, Rebecca M.; Huie, Kathleen E.; Coutermarsh-Ott, Sheryl; Eden, Kristin; McDaniel, Dylan K.; Verbridge, Scott S.; Rossmeisl, John H., Jr.; Oestreich, Kenneth J.; Davalos, Rafael, V; Allen, Irving C. (2019-06)
    Background: Despite promising treatments for breast cancer, mortality rates remain high and treatments for metastatic disease are limited. High-frequency irreversible electroporation (H-FIRE) is a novel tumor ablation ...
  • EGR1 recruits TET1 to shape the brain methylome during development and upon neuronal activity 

    Sun, Zhixiong; Xu, Xiguang; He, Jianlin; Murray, Alexander; Sun, Ming-an; Wei, Xiaoran; Wang, Xia; McCoig, Emmarose; Xie, Evan; Jiang, Xi; Li, Liwu; Zhu, Jinsong; Chen, Jianjun; Morozov, Alexei; Pickrell, Alicia M.; Theus, Michelle H.; Xie, Hehuang (2019-08-29)
    Life experience can leave lasting marks, such as epigenetic changes, in the brain. How life experience is translated into storable epigenetic information remains largely unknown. With unbiased data-driven approaches, we ...
  • Markedly different immune responses and virus kinetics in littermates infected with porcine circovirus type 2 or porcine parvovirus type 1 

    Opriessnig, Tanja; Gerber, Priscilla F.; Matzinger, Shannon R.; Meng, Xiang-Jin; Halbur, Patrick G. (2017-09)
    Porcine parvovirus type 1 (PPV1) and porcine circovirus type 2 (PCV2) are small single-stranded DNA viruses with high prevalence in the global pig population. The aim of this study was to compare and contrast PCV2 and PPV1 ...
  • ICTV Virus Taxonomy Profile: Hepeviridae 

    Purdy, Michael A.; Harrison, Tim J.; Jameel, S.; Meng, X-J.; Okamoto, H.; Van der Poel, W. H. M.; Smith, Donald B. (2017-11)
    The family Hepeviridae includes enterically transmitted small non-enveloped positive-sense RNA viruses. It includes the genera Piscihepevirus, whose members infect fish, and Orthohepevirus, whose members infect mammals and ...
  • Adventitious viruses persistently infect three commonly used mosquito cell lines 

    Weger-Lucarelli, James; Ruckert, Claudia; Grubaugh, Nathan D.; Misencik, Michael J.; Armstrong, Philip M.; Stenglein, Mark D.; Ebel, Gregory D.; Brackney, Doug E. (2018-08)
    Mosquito cell lines have been used extensively in research to isolate and propagate arthropod-borne viruses and understand virus-vector interactions. Despite their utility as an in vitro tool, these cell lines are poorly ...
  • Burden of lower respiratory infections in the Eastern Mediterranean Region between 1990 and 2015: findings from the Global Burden of Disease 2015 study 

    Mokdad, Ali H.; Moradi-Lakeh, Maziar; El Bcheraoui, Charbel; Charara, Raghid; Khalil, Ibrahim; Afshin, Ashkan; Kassebaum, Nicholas J.; Collison, Michael; Daoud, Farah; Chew, Adrienne; Krohn, Kristopher J.; Colombara, Danny; Ehrenkranz, Rebecca; Foreman, Kyle J.; Frostad, Joseph; Godwin, William W.; Kutz, Michael; Rao, Puja C.; Reiner, Robert; Troeger, Christopher; Wang, Haidong; Abajobir, Amanuel Alemu; Abbas, Kaja M.; Abera, Semaw Ferede; Abu-Raddad, Laith J.; Adane, Kelemework; Kiadaliri, Aliasghar Ahmad; Ahmadi, Alireza; Beshir, Muktar; Al-Eyadhy, Ayman; Alam, Khurshid; Alam, Noore; Alasfoor, Deena; Alizadeh-Navaei, Reza; Al-Maskari, Fatma; Al-Raddadi, Rajaa; Alsharif, Ubai; Altirkawi, Khalid A.; Anber, Nahla; Ansari, Hossein; Antonio, Carl Abelardo T.; Anwari, Palwasha; Asayesh, Hamid; Asgedom, Solomon Weldegebreal; Atey, Tesfay Mehari; Arthur, Euripide Frinel G.; Bacha, Umar; Barac, Aleksandra; Bazargan-Hejazi, Shahrzad; Drew, Charles R.; Geffen, David; Bedi, Neeraj; Bhutta, Zulfiqar A.; Michael, Brauer; Butt, Zahid A.; Castaneda-Orjuela, Carlos A.; Danawi, Hadi; Djalalinia, Shirin; Endries, Aman Yesuf; Eshrati, Babak; Farvid, Maryam S.; Fereshtehnejad, Seyed-Mohammad; Fischer, Florian; Garcia-Basteiro, Alberto L.; Gebrehiwot, Kiros Tedla; Gebrehiwot, Tsegaye Tewelde; Hailu, Gessessew Bugssa; Hamadeh, Randah Ribhi; Hambisa, Mitiku Teshome; Hamidi, Samer; Hassanvand, Mohammad Sadegh; Hedayati, Mohammad T.; Horita, Nobuyuki; Husseini, Abdullatif; Spencer, Lewis James; Javanbakht, Mehdi; Jonas, Jost B.; Kasaeian, Amir; Khader, Yousef Saleh; Khan, Ejaz Ahmad; Khan, Gulfaraz; Khoja, Abdullah Tawfih Abdullah; Khubchandani, Jagdish; Kim, Yun Jin; Kissoon, Niranjan; Larson, Heidi J.; Latif, Asma Abdul; Leshargie, Cheru Tesema; Lunevicius, Raimundas; Abd El Razek, Hassan Magdy; Abd El Razek, Mohammed Magdy; Majdzadeh, Reza; Majeed, Azeem; Malekzadeh, Reza; Farid, Habibolah Masoudi; Mehari, Alem; Memish, Ziad A.; Mengistu, Desalegn Tadese; Mensah, George A.; Mezgebe, Haftay Berhane; Nakamura, Sachiko; Oren, Eyal; Pourmalek, Farshad; Qorbani, Mostafa; Radfar, Amir; Rafay, Anwar; Vafa, Rahimi-Movaghar; Rai, Rajesh Kumar; Rawaf, David Laith; Rawaf, Salman; Refaat, Amany H.; Rezaei, Satar; Rezai, Mohammad Sadegh; Roba, Hirbo Shore; Roshandel, Gholamreza; Safdarian, Mahdi; Safiri, Saeid; Sahraian, Mohammad Ali; Salamati, Payman; Samy, Abdallah M.; Sartorius, Benn; Sepanlou, Sadaf G.; Shaikh, Masood Ali; Shamsizadeh, Morteza; Shigematsu, Mika; Singh, Jasvinder A.; Sufiyan, Muawiyyah Babale; Tehrani-Banihashemi, Arash; Temsah, Mohamad-Hani; Topor-Madry, Roman; Uthman, Olalekan A.; Vollset, Stein Emil; Wakayo, Tolassa; Werdecker, Andrea; Wijeratne, Tissa; Yaghoubi, Mohsen; Yimam, Hassen Hamid; Yonemoto, Naohiro; Younis, Mustafa Z.; Zaki, Maysaa El Sayed; Jumaan, Aisha O.; Vos, Theo; Naghavi, Mohsen; Hay, Simon I.; Murray, Christopher J. L. (2018-05)
    We used data from the Global Burden of Disease 2015 study (GBD) to calculate the burden of lower respiratory infections (LRIs) in the 22 countries of the Eastern Mediterranean Region (EMR) from 1990 to 2015. We conducted ...
  • Trends in HIV/AIDS morbidity and mortality in Eastern Mediterranean countries, 1990-2015: findings from the Global Burden of Disease 2015 study 

    Mokdad, Ali H.; El Bcheraoui, Charbel; Wang, Haidong; Charara, Raghid; Khalil, Ibrahim; Moradi-Lakeh, Maziar; Afshin, Ashkan; Collison, Michael; Daoud, Farah; Chew, Adrienne; Krohn, Kristopher J.; Carter, Austin; Foreman, Kyle J.; He, Fei; Kassebaum, Nicholas J.; Kutz, Michael; Mirarefin, Mojde; Nguyen, Grant; Silpakit, Naris; Sligar, Amber; Abajobir, Amanuel Alemu; Abate, Kalkidan Hassen; Abbas, Kaja M.; Abd-Allah, Foad; Abera, Semaw Ferede; Adane, Kelemework; Agarwal, Arnav; Kiadaliri, Aliasghar Ahmad; Ahmadi, Alireza; Ahmed, Muktar Beshir; Al Lami, Faris Hasan; Alam, Khurshid; Alasfoor, Deena; Alizadeh-Navaei, Reza; Al-Maskari, Fatma; Al-Raddadi, Rajaa; Altirkawi, Khalid A.; Alvis-Guzman, Nelson; Ammar, Walid; Anber, Nahla; Antonio, Carl Abelardo T.; Anwari, Palwasha; Asayesh, Hamid; Asghar, Rana Jawad; Atey, Tesfay Mehari; Avokpaho, Euripide Frinel G. Arthur; Ayele, Tadesse Awoke; Azzopardi, Peter; Bacha, Umar; Barac, Aleksandra; Baernighausen, Till; Bazargan-Hejazi, Shahrzad; Geffen, David; Bedi, Neeraj; Bensenor, Isabela M.; Berhane, Adugnaw; Bessong, Pascal Obong; Beyene, Addisu Shunu; Bhutta, Zulfiqar A.; Birungi, Charles; Butt, Zahid A.; Cahuana-Hurtado, Lucero; Danawi, Hadi; das Neves, Jose; Deribe, Kebede; Deribew, Amare; Jarlais, Don C. Des; Dharmaratne, Samath D.; Djalalinia, Shirin; Doyle, Kerrie E.; Endries, Aman Yesuf; Eshrati, Babak; Faraon, Emerito Jose Aquino; Farvid, Maryam S.; Fereshtehnejad, Seyed-Mohammad; Feyissa, Tesfaye Regassa; Fischer, Florian; Garcia-Basteiro, Alberto L.; Gebrehiwot, Tsegaye Tewelde; Gesesew, Hailay Abrha; Gishu, Melkamu Dedefo; Glaser, Elizabeth; Gona, Philimon N.; Gugnani, Harish Chander; Gupta, Rahul; Bidgoli, Hassan Haghparast; Hailu, Gessessew Bugssa; Hamadeh, Randah Ribhi; Hambisa, Mitiku Teshome; Hamidi, Samer; Harb, Hilda L.; Hareri, Habtamu Abera; Horita, Nobuyuki; Husseini, Abdullatif; Ibrahim, Ahmed; James, Spencer Lewis; Jonas, Jost B.; Kasaeian, Amir; Kassaw, Nigussie Assefa; Khader, Yousef Saleh; Khan, Ejaz Ahmad; Khan, Gulfaraz; Khoja, Abdullah Tawfih Abdullah; Khubchandani, Jagdish; Kim, Yun Jin; Koyanagi, Ai; Defo, Barthelemy Kuate; Larson, Heidi J.; Latif, Asma Abdul; Leshargie, Cheru Tesema; Lunevicius, Raimundas; Abd El Razek, Mohammed Magdy; Majdzadeh, Reza; Majeed, Azeem; Malekzadeh, Reza; Manyazewal, Tsegahun; Markos, Desalegn; Farid, Habibolah Masoudi; Mehari, Alem; Mekonnen, Alemayehu B.; Memiah, Peter; Memish, Ziad A.; Mendoza, Walter; Mengesha, Melkamu Merid; Mengistu, Desalegn Tadese; Mezgebe, Haftay Berhane; Mhimbira, Francis Apolinary; Miller, Ted R.; Moore, Ami R.; Mumtaz, Ghina R.; Natarajan, Gopalakrishnan; Negin, Joel; Obermeyer, Carla Makhlouf; Ogbo, Felix Akpojene; Oh, In-Hwan; Ota, Erika; Pereira, David M.; Pourmalek, Farshad; Qorbani, Mostafa; Radfar, Amir; Rafay, Anwar; Rahimi-Movaghar, Vafa; Rai, Rajesh Kumar; Ram, Usha; Rawaf, David Laith; Rawaf, Salman; Renzaho, Andre M. N.; Rezaei, Satar; Rezai, Mohammad Sadegh; Roba, Hirbo Shore; Roshandel, Gholamreza; Safdarian, Mahdi; Safiri, Saeid; Sahraian, Mohammad Ali; Salamati, Payman; Samy, Abdallah M.; Sartorius, Benn; Sepanlou, Sadaf G.; Shaikh, Masood Ali; Shamsizadeh, Morteza; Sibamo, Ephrem Lejore Sibamo; Singh, Jasvinder A.; Sobaih, Badr H. A.; Soshnikov, Sergey; Sufiyan, Muawiyyah Babale; Sykes, Bryan L.; Taveira, Nuno; Tegegne, Teketo Kassaw; Tehrani-Banihashemi, Arash; Tekelab, Tesfalidet; Shifa, Girma Temam; Temsah, Mohamad-Hani; Tesssema, Belay; Topor-Madry, Roman; Ukwaja, Kingsley Nnanna; Uthman, Olalekan A.; Vollset, Stein Emil; Wadilo, Fiseha; Wakayo, Tolassa; Alebachew, Minyahil; Workicho, Abdulhalik; Workie, Shimelash Bitew; Yaghoubi, Mohsen; Yalew, Ayalnesh Zemene; Yimam, Hassen Hamid; Yonemoto, Naohiro; Yoon, Seok-Jun; Yotebieng, Marcel; Younis, Mustafa Z.; Zaki, Maysaa El Sayed; Jumaan, Aisha O.; Vos, Theo; Hay, Simon I.; Naghavi, Mohsen; Murray, Christopher J. L. (2018-05)
    We used the results of the Global Burden of Disease 2015 study to estimate trends of HIV/AIDS burden in Eastern Mediterranean Region (EMR) countries between 1990 and 2015. Tailored estimation methods were used to produce ...
  • Chronic Cerebral Hypoperfusion Induces Alterations of Matrix Metalloproteinase-9 and Angiopoietin-2 Levels in the Rat Hippocampus 

    Kim, Min-Soo; Choi, Bo-Ryoung; Lee, Yong Woo; Kim, Dong-Hee; Han, Ye Sun; Jeon, Won Kyung; Han, Jung-Soo (2018-08)
    Angiogenic factors contribute to cerebral angiogenesis following cerebral hypoperfusion, and understanding these temporal changes is essential to developing effective treatments. The present study examined temporal alterations ...
  • The Komodo dragon (Varanus komodoensis) genome and identification of innate immunity genes and clusters 

    van Hoek, Monique L.; Prickett, M. D.; Settlage, Robert E.; Kang, Lin; Michalak, Pawel; Vliet, Kent A.; Bishop, Barney M. (2019-08-30)
    Abstract Background We report the sequencing, assembly and analysis of the genome of the Komodo dragon (Varanus komodoensis), the largest extant lizard, with a focus on ...
  • Dietary epicatechin improves survival and delays skeletal muscle degeneration in aged mice 

    Si, Hongwei; Wang, Xiaoyong; Zhang, Longyun; Parnell, Laurence D.; Admed, Bulbul; LeRoith, Tanya; Ansah, Twum-Ampofo; Zhang, Lijuan; Li, Jianwei; Ordovas, Jose M.; Si, Hongzong; Liu, Dongmin; Lai, Chao-Qiang (2019-01)
    We recently reported that epicatechin, a bioactive compound that occurs naturally in various common foods, promoted general health and survival of obese diabetic mice. It remains to be determined whether epicatechin extends ...
  • Maternal Influence and Murine Housing Confound Impact of NLRP1 Inflammasome on Microbiome Composition 

    Ringel-Scaia, Veronica M.; Qin, Yufeng; Thomas, Cassidy A.; Huie, Kathleen E.; McDaniel, Dylan K.; Eden, Kristin; Wade, Paul A.; Allen, Irving C. (2019-02-13)
    The NLRP1 inflammasome attenuates inflammatory bowel disease (IBD) progression and colitis-associated tumorigenesis. A possible mechanism postulates that the lack of the NLRP1 inflammasome creates permissive niches in the ...
  • Mutations present in a low-passage Zika virus isolate result in attenuated pathogenesis in mice 

    Duggal, Nisha K.; McDonald, Erin M.; Weger-Lucarelli, James; Hawks, Seth A.; Ritter, Jana M.; Romo, Hannah; Ebel, Gregory D.; Brault, Aaron C. (2019-04)
    Zika virus (ZIKV) infection can result in neurological disorders including Congenital Zika Syndrome in infants exposed to the virus in utero. Pregnant women can be infected by mosquito bite as well as by sexual transmission ...
  • Analysis of the antigenic determinants of the OspC protein of the Lyme disease spirochetes: Evidence that the C10 motif is not immunodominant or required to elicit bactericidal antibody responses 

    Izac, Jerilyn R.; Camire, Andrew C.; Earnhart, Christopher G.; Embers, Monica E.; Funk, Rebecca A.; Breitschwerdt, Edward B.; Marconi, Richard T. (2019-04-17)
    As Ixodes ticks spread to new regions, the incidence of Lyme disease (LD) in companion animals and humans will increase. Preventive strategies for LD in canines center on vaccination and tick control (acaricides). Both ...
  • Divergent age-dependent peripheral immune transcriptomic profile following traumatic brain injury 

    Hazy, Amanda; Bochicchio, Lauren; Oliver, Andrea; Xie, Eric; Geng, Shuo; Brickler, Thomas; Xie, Hehuang; Li, Liwu; Allen, Irving C.; Theus, Michelle H. (2019-06-12)
    The peripheral immune system is a major regulator of the pathophysiology associated with traumatic brain injury (TBI). While age-at-injury influences recovery from TBI, the differential effects on the peripheral immune ...
  • Small RNA responses of Culex mosquitoes and cell lines during acute and persistent virus infection 

    Ruckert, Claudia; Prasad, Abhishek N.; Garcia-Luna, Selene M.; Robison, Alexis; Grubaugh, Nathan D.; Weger-Lucarelli, James; Ebel, Gregory D. (2019-06)
    RNA interference is a crucial antiviral mechanism in arthropods, including in mosquito vectors of arthropod-borne viruses (arboviruses). Although the exogenous small interfering RNA (siRNA) pathway constitutes an efficient ...
  • Genomic divergence and adaptive convergence in Drosophila simulans from Evolution Canyon, Israel 

    Kang, Lin; Rashkovetsky, Eugenia; Michalak, Katarzyna; Garner, Harold R.; Mahaney, James E.; Rzigalinski, Beverly A.; Korol, Abraham; Nevo, Eviatar; Michalak, Pawel (2019-06-11)
    Biodiversity refugia formed by unique features of the Mediterranean arid landscape, such as the dramatic ecological contrast of "Evolution Canyon," provide a natural laboratory in which local adaptations to divergent ...

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