Conformationally constrained paclitaxel analogs and their use as anticancer and anti-Alzheimers agents
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Date
2007-12-25
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United States Patent and Trademark Office
Abstract
Constrained paclitaxel derivatives include a bridge extending from the C-3′ phenyl to either the C4 or -3 positions. Many of the constrained paclitaxel derivatives provide activity comparable or superior to the natural product paclitaxel.