Browsing Destination Area: Adaptive Brain and Behavior (ABB) by Title
Now showing items 1-20 of 301
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7.0-T Magnetic Resonance Imaging Characterization of Acute Blood-Brain-Barrier Disruption Achieved with Intracranial Irreversible Electroporation
(PLOS, 2012-11-30)The blood-brain-barrier (BBB) presents a significant obstacle to the delivery of systemically administered chemotherapeutics for the treatment of brain cancer. Irreversible electroporation (IRE) is an emerging technology ... -
A developmental sex difference in hippocampal neurogenesis is mediated by endogenous Oestradiol
(BMC, 2010)Background: Oestradiol is a steroid hormone that exerts extensive influence on brain development and is a powerful modulator of hippocampal structure and function. The hippocampus is a critical brain region regulating ... -
A Molecular Mechanism Regulating the Timing of Corticogeniculate Innervation
(Elsevier, 2013-11-14)Neural circuit formation demands precise timing of innervation by different classes of axons. However, the mechanisms underlying such activity remain largely unknown. In the dorsal lateral geniculate nucleus (dLGN), axons ... -
Aberrant Calcium Signaling in Astrocytes Inhibits Neuronal Excitability in a Human Down Syndrome Stem Cell Model
(Elsevier, 2018-07-10)Down syndrome (DS) is a genetic disorder that causes cognitive impairment. The staggering effects associated with an extra copy of human chromosome 21 (HSA21) complicates mechanistic understanding of DS pathophysiology. ... -
Acetylcholine Receptor Activation as a Modulator of Glioblastoma Invasion
(MDPI, 2019-10-05)Grade IV astrocytomas, or glioblastomas (GBMs), are the most common malignant primary brain tumor in adults. The median GBM patient survival of 12–15 months has remained stagnant, in spite of treatment strategies, ... -
Acoustic differences between healthy and depressed people: a cross-situation study
(2019-10-15)Abstract Background Abnormalities in vocal expression during a depressed episode have frequently been reported in people with depression, but less is known about if these ... -
Active inference and agency: optimal control without cost functions
(Springer, 2012-08-03)This paper describes a variational free-energy formulation of (partially observable) Markov decision problems in decision making under uncertainty. We show that optimal control can be cast as active inference. In active ... -
Activity Dependent Protein Degradation Is Critical for the Formation and Stability of Fear Memory in the Amygdala
(PLOS, 2011-09)Protein degradation through the ubiquitin-proteasome system [UPS] plays a critical role in some forms of synaptic plasticity. However, its role in memory formation in the amygdala, a site critical for the formation of fear ... -
Adaptive Brain and Behavior Across the Lifespan
(Virginia Tech, 2016-05)Our aim is to understand adaptation and improve human lives in various contexts. Inequalities and environments in which people live affect their health and behavior — and their success of remaining healthy for a lifetime. ... -
Aging and network properties: Stability over time and links with learning during working memory training
(Frontiers Media S.A., 2018-01-04)Growing evidence suggests that healthy aging affects the configuration of large-scale functional brain networks. This includes reducing network modularity and local efficiency. However, the stability of these effects over ... -
Aging into Perceptual Control: A Dynamic Causal Modeling for fMRI Study of Bistable Perception
(Frontiers, 2016-03-31)Aging is accompanied by stereotyped changes in functional brain activations, for example a cortical shift in activity patterns from posterior to anterior regions is one hallmark revealed by functional magnetic resonance ... -
Aging, resistance training, and diabetes prevention.
(2010-12-15)With the aging of the baby-boom generation and increases in life expectancy, the American population is growing older. Aging is associated with adverse changes in glucose tolerance and increased risk of diabetes; the ... -
Agrin and Synaptic Laminin Are Required to Maintain Adult Neuromuscular Junctions
(PLOS, 2012-10-03)As synapses form and mature the synaptic partners produce organizing molecules that regulate each other’s differentiation and ensure precise apposition of pre- and post-synaptic specializations. At the skeletal neuromuscular ... -
Alexithymia as a Transdiagnostic Precursor to Empathy Abnormalities: The Functional Role of the Insula
(Frontiers, 2017-12-21)Distorted empathic processing has been observed across multiple psychiatric disorders. Simulation theory provides a theoretical framework that proposes a mechanism through which empathy difficulties may arise. Specifically, ... -
Alexithymic Trait and Voluntary Control in Healthy Adults
(PLOS, 2008-11-12)Background: Alexithymia is a personality trait characterized by deficiency in understanding, processing, or describing emotions. Recent studies have revealed that alexithymia is associated with less activation of the ... -
The ALS-inducing factors, TDP43A315T and SOD1G93A, directly affect and sensitize sensory neurons to stress
(Nature, 2018-11-08)There is increased recognition that sensory neurons located in dorsal root ganglia (DRG) are affected in amyotrophic lateral sclerosis (ALS). However, it remains unknown whether ALS-inducing factors, other than mutant ... -
Alterations in Brain Connectivity Underlying Beta Oscillations in Parkinsonism
(PLOS, 2011-08-11)Cortico-basal ganglia-thalamocortical circuits are severely disrupted by the dopamine depletion of Parkinson’s disease (PD), leading to pathologically exaggerated beta oscillations. Abnormal rhythms, found in several circuit ... -
Altered Expression of Human Mitochondrial Branched Chain Aminotransferase in Dementia with Lewy Bodies and Vascular Dementia
(2017-01)Cytosolic and mitochondrial human branched chain aminotransferase (hBCATc and hBCATm, respectively) play an integral role in brain glutamate metabolism. Regional increased levels of hBCATc in the CA1 and CA4 region of ... -
Altered peripheral immune profiles in treatment-resistant depression: response to ketamine and prediction of treatment outcome.
A subset of patients with depression have elevated levels of inflammatory cytokines, and some studies demonstrate interaction between inflammatory factors and treatment outcome. However, most studies focus on only a narrow ... -
Altered phosphorylation, electrophysiology, and behavior on attenuation of PDE4B action in hippocampus
(BMC, 2017)Background: PDE4 cyclic nucleotide phosphodiesterases regulate 3′, 5′ cAMP abundance in the CNS and thereby regulate PKA activity and phosphorylation of CREB, which has been implicated in learning and memory, depression ...
