Browsing Destination Area: Adaptive Brain and Behavior (ABB) by Title
Now showing items 1-20 of 216
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7.0-T Magnetic Resonance Imaging Characterization of Acute Blood-Brain-Barrier Disruption Achieved with Intracranial Irreversible Electroporation
(PLOS, 2012-11-30)The blood-brain-barrier (BBB) presents a significant obstacle to the delivery of systemically administered chemotherapeutics for the treatment of brain cancer. Irreversible electroporation (IRE) is an emerging technology ... -
A developmental sex difference in hippocampal neurogenesis is mediated by endogenous Oestradiol
(BMC, 2010)Background: Oestradiol is a steroid hormone that exerts extensive influence on brain development and is a powerful modulator of hippocampal structure and function. The hippocampus is a critical brain region regulating ... -
A Molecular Mechanism Regulating the Timing of Corticogeniculate Innervation
(Elsevier, 2013-11-14)Neural circuit formation demands precise timing of innervation by different classes of axons. However, the mechanisms underlying such activity remain largely unknown. In the dorsal lateral geniculate nucleus (dLGN), axons ... -
Active inference and agency: optimal control without cost functions
(Springer, 2012-08-03)This paper describes a variational free-energy formulation of (partially observable) Markov decision problems in decision making under uncertainty. We show that optimal control can be cast as active inference. In active ... -
Activity Dependent Protein Degradation Is Critical for the Formation and Stability of Fear Memory in the Amygdala
(PLOS, 2011-09)Protein degradation through the ubiquitin-proteasome system [UPS] plays a critical role in some forms of synaptic plasticity. However, its role in memory formation in the amygdala, a site critical for the formation of fear ... -
Adaptive Brain and Behavior Across the Lifespan
(Virginia Tech, 2016-05)Our aim is to understand adaptation and improve human lives in various contexts. Inequalities and environments in which people live affect their health and behavior — and their success of remaining healthy for a lifetime. ... -
Aging, resistance training, and diabetes prevention.
(2010-12-15)With the aging of the baby-boom generation and increases in life expectancy, the American population is growing older. Aging is associated with adverse changes in glucose tolerance and increased risk of diabetes; the ... -
Agrin and Synaptic Laminin Are Required to Maintain Adult Neuromuscular Junctions
(PLOS, 2012-10-03)As synapses form and mature the synaptic partners produce organizing molecules that regulate each other’s differentiation and ensure precise apposition of pre- and post-synaptic specializations. At the skeletal neuromuscular ... -
Alexithymia as a Transdiagnostic Precursor to Empathy Abnormalities: The Functional Role of the Insula
(Frontiers, 2017-12-21)Distorted empathic processing has been observed across multiple psychiatric disorders. Simulation theory provides a theoretical framework that proposes a mechanism through which empathy difficulties may arise. Specifically, ... -
The ALS-inducing factors, TDP43A315T and SOD1G93A, directly affect and sensitize sensory neurons to stress
(Nature, 2018-11-08)There is increased recognition that sensory neurons located in dorsal root ganglia (DRG) are affected in amyotrophic lateral sclerosis (ALS). However, it remains unknown whether ALS-inducing factors, other than mutant ... -
Altered peripheral immune profiles in treatment-resistant depression: response to ketamine and prediction of treatment outcome.
A subset of patients with depression have elevated levels of inflammatory cytokines, and some studies demonstrate interaction between inflammatory factors and treatment outcome. However, most studies focus on only a narrow ... -
Altered phosphorylation, electrophysiology, and behavior on attenuation of PDE4B action in hippocampus
(BMC, 2017)Background: PDE4 cyclic nucleotide phosphodiesterases regulate 3′, 5′ cAMP abundance in the CNS and thereby regulate PKA activity and phosphorylation of CREB, which has been implicated in learning and memory, depression ... -
Anxiety Disorders and Obsessive-Compulsive Disorders (OCD)
(Springer, 2016-02-04)Anxiety is known to be a commonly, co-occurring phenomenon with autism. Also, in daily practice, these symptoms often are confused with core symptoms of autism. Accurately determining OCD and anxiety from autism has important ... -
Associability-modulated loss learning is increased in posttraumatic stress disorder
(eLife Sciences, 2018-01-09)Disproportionate reactions to unexpected stimuli in the environment are a cardinal symptom of posttraumatic stress disorder (PTSD). Here, we test whether these heightened responses are associated with disruptions in distinct ... -
Associations between Parental Anxiety/Depression and Child Behavior Problems Related to Autism Spectrum Disorders: The Roles of Parenting Stress and Parenting Self-Efficacy
(Hindawi, 2011-12-13)Parents of children with autism spectrum disorders (ASDs) have been shown to experience increases in stress, depression, and anxiety, which are also associated with child behavior problems related to ASDs. Literature-examining ... -
Attempted Suicide in a Parkinsonian Patient Treated with DBS of the VIM and High Dose Carbidopa-Levodopa
(Hindawi Publishing Corp, 2019-03-26)Introduction. Parkinson’s disease (PD) is a complex disease that is often treated with dopaminergic medications such as carbidopa-levodopa and now with innovative interventions such as deep brain stimulation (DBS). While ... -
Automated Functional Analysis of Astrocytes from Chronic Time-Lapse Calcium Imaging Data
(Frontiers, 2017-07-14)Recent discoveries that astrocytes exert proactive regulatory effects on neural information processing and that they are deeply involved in normal brain development and disease pathology have stimulated broad interest in ... -
BDNF Val(66)Met Polymorphism Influences Visuomotor Associative Learning and the Sensitivity to Action Observation
(Springer Nature, 2016-10-05)Motor representations in the human mirror neuron system are tuned to respond to specific observed actions. This ability is widely believed to be influenced by genetic factors, but no study has reported a genetic variant ... -
BDNF Val(66)Met Polymorphism Is Associated with Self-Reported Empathy
(PLOS, 2016-02-12)Empathy is an important driver of human social behaviors and presents genetic roots that have been studied in neuroimaging using the intermediate phenotype approach. Notably, the Val66Met polymorphism of the Brain-derived ... -
Beginning A Patient-Centered Approach in the Design of A Diabetes Prevention Program
(Mdpi Ag, 2014-02-01)
