The DA Data and Decisions advances the human condition and society with better decisions through data. D&D integrates all DAs and SGAs with data analytics and decision sciences.  Work in this area embraces equity in the human condition by seeking the equitable distribution and availability of physical safety and well-being, psychological well-being, respect for human dignity, and access to crucial material and social resources throughout the world’s diverse communities. D&D also addresses policymaking and policy analysis, collaborating at the intersection of scientific evidence, governance, and analyses to translate scholarship into practice.

Recent Submissions

  • Forecasting Model for Air Taxi, Commercial Airline, and Automobile Demand in the United States 

    Baik, Hojong; Trani, Antonio A.; Hinze, Nicolas; Swingle, Howard; Ashiabor, Senanu; Seshadri, Anand (Transportation Research Board of the National Academies, 2008)
    A nationwide model predicts the annual county-to-county person roundtrips for air taxi, commercial airline, and automobile at 1-year intervals through 2030. The transportation systems analysis model (TSAM) uses the four-step ...
  • Characterizing the Genetic Basis for Nicotine Induced Cancer Development: A Transcriptome Sequencing Study 

    Bavarva, Jasmin H.; Tae, Hongseok; Settlage, Robert E.; Garner, Harold R. (PLOS, 2013-06-18)
    Nicotine is a known risk factor for cancer development and has been shown to alter gene expression in cells and tissue upon exposure. We used Illumina® Next Generation Sequencing (NGS) technology to gain unbiased biological ...
  • High Resolution Discovery Proteomics Reveals Candidate Disease Progression Markers of Alzheimer’s Disease in Human Cerebrospinal Fluid 

    Hendrickson, Ronald C.; Lee, Anita Y.H.; Song, Qinghua; Liaw, Andy; Winer, Matt; Paweletz, Cloud P.; Seeburger, Jeffrey L.; Li, Jenny; Meng, Fanyu; Deyanova, Ekaterina G.; Mazur, Matthew T.; Settlage, Robert E.; Zhao, Xuemei; Southwick, Katie; Du, Yi; Holder, Dan; Sachs, Jeffrey R.; Laterza, Omar F.; Dallob, Aimee; Chappell, Derek L.; Snyder, Karen; Modur, Vijay; King, Elizabeth; Joachim, Catharine; Bondarenko, Andrey Y.; Shearman, Mark; Soper, Keith A.; Smith, A. David; Potter, William Z.; Koblan, Ken S.; Sachs, Alan B.; Yates, Nathan A. (PLOS, 2015-08-13)
    Disease modifying treatments for Alzheimer’s disease (AD) constitute a major goal in medicine. Current trends suggest that biomarkers reflective of AD neuropathology and modifiable by treatment would provide supportive ...
  • Cross-scale Perspectives: Integrating Long-term and High-frequency Data into Our Understanding of Communities and Ecosystems 

    Carey, Cayelan C.; Cottingham, Kathryn L. (Ecological Society of America, 2016-01)
    Ecologists are amassing extensive data sets that include both long-term records documenting trends and variability in natural systems on inter-annual to decadal time scales and sensor-based measurements on minute to subhourly ...
  • Applying Best Supply Chain Practices to Humanitarian Relief 

    Russell, Roberta S.; Hiller, Janine S. (Penn State, 2015-05)
    With the growth in length and breadth of extended supply chains, more companies are employing risk management techniques and resilience planning to deal with burgeoning and costly supply chain disruptions. As companies can ...
  • Describing the Relationship between Cat Bites and Human Depression Using Data from an Electronic Health Record 

    Hanauer, David A.; Ramakrishnan, Naren; Seyfried, Lisa S. (PLOS, 2013-08-01)
    Data mining approaches have been increasingly applied to the electronic health record and have led to the discovery of numerous clinical associations. Recent data mining studies have suggested a potential association between ...
  • A Model for a Smallpox-Vaccination Policy 

    Bozzette, Samuel A.; Boer, Rob; Bhatnagar, Vibha; Brower, Jennifer L.; Keeler, Emmett B.; Morton, Sally C.; Stoto, Michael A. (NEJM Group, 2003-01-30)
    Background: The new reality of biologic terrorism and warfare has ignited a debate about whether to reintroduce smallpox vaccination. Methods: We developed scenarios of smallpox attacks and built a stochastic model of ...
  • Efficacy and Safety of Ephedra and Ephedrine for Weight Loss and Athletic Performance: A Meta-analysis 

    Shekelle, Paul G.; Hardy, Mary; Morton, Sally C.; Maglione, Margaret; Mojica, Walter A.; Suttorp, Marika J.; Rhodes, Shannon L.; Jungvig, Lara; Gagné, James (AMA, 2003-03-26)
    CONTEXT: Ephedra and ephedrine sometimes are used for weight loss or enhanced athletic performance, but the efficacy and safety of these compounds are uncertain. OBJECTIVE: To assess the efficacy and safety of ephedra ...
  • The effectiveness of computerized order entry at reducing preventable adverse drug events and medication errors in hospital settings: a systematic review and meta-analysis reducing preventable adverse drug events and medication errors in hospital settings: a systematic review and meta-analysis 

    Nuckols, Teryl K.; Smith-Spangler, Crystal; Morton, Sally C.; Asch, Steven M.; Patel, Vaspaan M.; Anderson, Laura J.; Deichsel, Emily L.; Shekelle, Paul G. (BMC, 2014)
    Background: The Health Information Technology for Economic and Clinical Health (HITECH) Act subsidizes implementation by hospitals of electronic health records with computerized provider order entry (CPOE), which may reduce ...
  • Ephedra 

    Morton, Sally C. (Institute of Mathematical Statistics, 2005-08)
    In February 2004, the U.S. Food and Drug Administration (FDA) prohibited the sale of dietary supplements containing ephedrine alkaloids (ephedra), stating that such supplements present an unreasonable risk of illness or ...
  • Are Ayurvedic herbs for diabetes effective? 

    Shekelle, Paul G.; Hardy, Mary; Morton, Sally C.; Coulter, Ian; Venuturupalli, Swamy; Favreau, Joya; Hilton, Lara K. (Frontline Medical Communications Inc., 2005-10)
    Objective: To evaluate and synthesize the evidence on the effect of Ayurvedic therapies for diabetes mellitus. Design: Systematic review of trials. Measurements and main results: We found no study that assessed ...
  • Interventions for the prevention of falls in older adults: systematic review and meta-analysis of randomised clinical trials 

    Chang, John T.; Morton, Sally C.; Rubenstein, Laurence Z.; Mojica,Walter A.; Maglione, Margaret; Suttorp, Marika J.; Roth, Elizabeth A.; Shekelle, Paul G. (BMJ Publishing Group Ltd, 2004-03-20)
    Objective: To assess the relative effectiveness of interventions to prevent falls in older adults to either a usual care group or control group. Design: Systematic review and meta-analyses. Data sources Medline, ...
  • Effects of Omega-3 Fatty Acids on Cancer Risk 

    MacLean, Catherine H.; Newberry, Sydne J.; Mojica, Walter A.; Khanna, Puja; Issa, Amalia M.; Suttorp, Marika J.; Lim, Yee-Wee; Traina, Shana B.; Hilton, Lara; Garland, Rena; Morton, Sally C. (AMA, 2006-04)
    Context: Omega-3 fatty acids are purported to reduce the risk of cancer. Studies have reported mixed results. Objective: To synthesize published and unpublished evidence to determine estimates of the effect of omega-3 ...
  • Can Administrative Housing Data Replace Survey Data? 

    Molfino, Emily; Korkmaz, Gizem; Keller, Sallie A.; Schroeder, Aaron; Shipp, Stephanie; Weinberg, Daniel H. (HUD, 2017)
    This article examines the feasibility of using local administrative data sources for enhancing and supplementing federally collected survey data to describe housing in Arlington County, Virginia. Using real estate assessment ...
  • Human Initiated Cascading Failures in Societal Infrastructures 

    Barrett, Chris; Channakeshava, Karthik; Huang, Fei; Kim, Junwhan; Marathe, Achla; Marathe, Madhav V.; Pei, Guanhong; Saha, Sudip; Subbiah, Balaaji S.P.; Vullikanti, Anil Kumar S. (PLOS, 2012-10-31)
    In this paper, we conduct a systematic study of human-initiated cascading failures in three critical inter-dependent societal infrastructures due to behavioral adaptations in response to a crisis. We focus on three closely ...
  • Therapeutic effects of adropin on glucose tolerance and substrate utilization in diet-induced obese mice with insulin resistance 

    Gao, Su; McMillan, Ryan P.; Zhu, Qingzhang; Lopaschuk, Gary D.; Hulver, Matthew W.; Butler, Andrew A. (Elsevier, 2015-01-17)
    Objective: The peptide hormone adropin regulates fuel selection preferences in skeletal muscle under fed and fasted conditions. Here, we investigated whether adropin treatment can ameliorate the dysregulation of fuel ...
  • Remodeling Lipid Metabolism and Improving Insulin Responsiveness in Human Primary Myotubes 

    Sparks, Lauren M.; Moro, Cedric; Ukropcova, Barbara; Bajpeyi, Sudip; Civitarese, Anthony E.; Hulver, Matthew M.; Thoresen, G. Hege; Rustan, Arild C.; Smith, Steven R. (PLOS, 2011-07-08)
    Objective: Disturbances in lipid metabolism are strongly associated with insulin resistance and type 2 diabetes (T2D). We hypothesized that activation of cAMP/PKA and calcium signaling pathways in cultured human myotubes ...
  • Fish oil and indomethacin in combination potently reduce dyslipidemia and hepatic steatosis in LDLR⁻/⁻ mice 

    Murali, Ganesan; Milne, Ginger L.; Webb, Corey D.; Stewart, Ann B.; McMillan, Ryan P.; Lyle, Brandon C.; Hulver, Matthew W.; Saraswathi, Viswanathan (ASBMB, 2012-07-29)
    Fish oil (FO) is a potent anti-inflammatory and lipid-lowering agent. Because inflammation can modulate lipid metabolism and vice versa, we hypothesized that combining FO with cyclooxygenase inhibitors (COXIBs), well-known ...
  • Control of mitochondrial metabolism and systemic energy homeostasis by microRNAs 378 and 378* 

    Carrer, Michele; Liu, Ning; Grueter, Chad E.; Williams, Andrew H.; Frisard, Madlyn I.; Hulver, Matthew W.; Bassel-Duby, Rhonda; Olson, Eric N. (NAS, 2012-09-18)
    Obesity and metabolic syndrome are associated with mitochondrial dysfunction and deranged regulation of metabolic genes. Peroxisome proliferator-activated receptor γ coactivator 1β (PGC-1β) is a transcriptional coactivator ...
  • The molecular mechanism linking muscle fat accumulation to insulin resistance 

    Dohm, G. Lynis; Hulver, Matthew W. (The Nutrition Society, 2004)
    Skeletal muscle insulin resistance is a co-morbidity of obesity and a risk factor for the development of type 2 diabetes mellitus. Insulin resistance is associated with the accumulation of intramyocellular lipids. ...

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