Now showing items 1-20 of 106

    • A Model for a Smallpox-Vaccination Policy 

      Bozzette, Samuel A.; Boer, Rob; Bhatnagar, Vibha; Brower, Jennifer L.; Keeler, Emmett B.; Morton, Sally C.; Stoto, Michael A. (NEJM Group, 2003-01-30)
      Background: The new reality of biologic terrorism and warfare has ignited a debate about whether to reintroduce smallpox vaccination. Methods: We developed scenarios of smallpox attacks and built a stochastic model of ...
    • Efficacy and Safety of Ephedra and Ephedrine for Weight Loss and Athletic Performance: A Meta-analysis 

      Shekelle, Paul G.; Hardy, Mary; Morton, Sally C.; Maglione, Margaret; Mojica, Walter A.; Suttorp, Marika J.; Rhodes, Shannon L.; Jungvig, Lara; Gagné, James (AMA, 2003-03-26)
      CONTEXT: Ephedra and ephedrine sometimes are used for weight loss or enhanced athletic performance, but the efficacy and safety of these compounds are uncertain. OBJECTIVE: To assess the efficacy and safety of ephedra ...
    • The molecular mechanism linking muscle fat accumulation to insulin resistance 

      Dohm, G. Lynis; Hulver, Matthew W. (The Nutrition Society, 2004)
      Skeletal muscle insulin resistance is a co-morbidity of obesity and a risk factor for the development of type 2 diabetes mellitus. Insulin resistance is associated with the accumulation of intramyocellular lipids. ...
    • Interventions for the prevention of falls in older adults: systematic review and meta-analysis of randomised clinical trials 

      Chang, John T.; Morton, Sally C.; Rubenstein, Laurence Z.; Mojica,Walter A.; Maglione, Margaret; Suttorp, Marika J.; Roth, Elizabeth A.; Shekelle, Paul G. (BMJ Publishing Group Ltd, 2004-03-20)
      Objective: To assess the relative effectiveness of interventions to prevent falls in older adults to either a usual care group or control group. Design: Systematic review and meta-analyses. Data sources Medline, ...
    • Ephedra 

      Morton, Sally C. (Institute of Mathematical Statistics, 2005-08)
      In February 2004, the U.S. Food and Drug Administration (FDA) prohibited the sale of dietary supplements containing ephedrine alkaloids (ephedra), stating that such supplements present an unreasonable risk of illness or ...
    • Are Ayurvedic herbs for diabetes effective? 

      Shekelle, Paul G.; Hardy, Mary; Morton, Sally C.; Coulter, Ian; Venuturupalli, Swamy; Favreau, Joya; Hilton, Lara K. (Frontline Medical Communications Inc., 2005-10)
      Objective: To evaluate and synthesize the evidence on the effect of Ayurvedic therapies for diabetes mellitus. Design: Systematic review of trials. Measurements and main results: We found no study that assessed ...
    • Effects of Omega-3 Fatty Acids on Cancer Risk 

      MacLean, Catherine H.; Newberry, Sydne J.; Mojica, Walter A.; Khanna, Puja; Issa, Amalia M.; Suttorp, Marika J.; Lim, Yee-Wee; Traina, Shana B.; Hilton, Lara; Garland, Rena; Morton, Sally C. (AMA, 2006-04)
      Context: Omega-3 fatty acids are purported to reduce the risk of cancer. Studies have reported mixed results. Objective: To synthesize published and unpublished evidence to determine estimates of the effect of omega-3 ...
    • Unsupervised clustering of gene expression data points at hypoxia as possible trigger for metabolic syndrome 

      Ptitsyn, Andrey; Hulver, Matthew W.; Cefalu, William; York, David; Smith, Steven R (2006-12-19)
      Background Classification of large volumes of data produced in a microarray experiment allows for the extraction of important clues as to the nature of a disease. Results Using multi-dimensional unsupervised FOREL (FORmal ...
    • Mining Novellas from PubMed Abstracts using a Storytelling Algorithm 

      Gresock, Joseph; Kumar, Deept; Helm, Richard; Potts, Malcolm; Ramakrishnan, Naren (Department of Computer Science, Virginia Polytechnic Institute & State University, 2007), TR-07-08
      Motivation: There are now a multitude of articles published in a diversity of journals providing information about genes, proteins, pathways, and entire processes. Each article investigates particular subsets of a biological ...
    • Compositional Mining of Multi-Relational Biological Datasets 

      Jin, Ying; Murali, T. M.; Ramakrishnan, Naren (Department of Computer Science, Virginia Polytechnic Institute & State University, 2007-08-01), TR-07-29
      High-throughput biological screens are yielding ever-growing streams of information about multiple aspects of cellular activity. As more and more categories of datasets come online, there is a corresponding multitude of ...
    • Forecasting Model for Air Taxi, Commercial Airline, and Automobile Demand in the United States 

      Baik, Hojong; Trani, Antonio A.; Hinze, Nicolas; Swingle, Howard; Ashiabor, Senanu; Seshadri, Anand (Transportation Research Board of the National Academies, 2008)
      A nationwide model predicts the annual county-to-county person roundtrips for air taxi, commercial airline, and automobile at 1-year intervals through 2030. The transportation systems analysis model (TSAM) uses the four-step ...
    • Crisis, Tragedy, and Recovery Network (CTRnet) 

      Fox, Edward A. (2009-09-14)
      This poster provides an overview of the Crisis, Tragedy, and Recovery Network (CTRnet). The objectives of CTRnet are to build a digital library and preserve information (in various formats like HTML, images, videos, etc.) ...
    • Systems Integration of Biodefense Omics Data for Analysis of Pathogen-Host Interactions and Identification of Potential Targets 

      McGarvey, Peter B.; Huang, Hongzhan|Mazumder, Raja; Zhang, Jian; Chen, Yongxing; Zhang, Chengdong; Cammer, Stephen; Will, Rebecca; Odle, Margie; Sobral, Brun; Moore, Margare; Wu, Cathy H. (Public Library of Science, 2009-09-25)
      The NIAID (National Institute for Allergy and Infectious Diseases) Biodefense Proteomics program aims to identify targets for potential vaccines, therapeutics, and diagnostics for agents of concern in bioterrorism, including ...
    • Data Mining and Gap Analysis for Weather Responsive Traffic Management Program 

      Krechmer, Daniel; Rakha, Hesham A.; Howard, Mark; Huang, Weimin; Zohdy, Ismail; Du, Jianhe (United States. Federal Highway Administration, 2010)
      Weather causes a variety of impacts on the transportation system. An Oak Ridge National Laboratory study estimated the delay experienced by American drivers due to snow, ice, and fog in 1999 at 46 million hours. While ...
    • Designing for Schadenfreude (or, how to express well-being and see if youʼre boring people) 

      André, Paul; Schraefel, M.C.; Dix, Alan; White, Ryen W.; Bernstein, Michael; Luther, Kurt (ACM, 2010)
      This position paper presents two studies of content not normally expressed in status updates—well-being and status feedback—and considers how they may be processed, valued and used for potential quality-of-life benefits ...
    • Global estimates of CO sources with high resolution by adjoint inversion of multiple satellite datasets (MOPITT, AIRS, SCIAMACHY, TES) 

      Kopacz, M.; Jacob, D. J.; Fisher, J. A.; Logan, J. A.; Zhang, L.; Megretskaia, I. A.; Yantosca, R. M.; Singh, K.; Henze, D. K.; Burrows, J. P.; Buchwitz, M.; Khlystova, I.; McMillan, W. W.; Gille, J. C.; Edwards, D. P.; Eldering, A.; Thouret, V.; Nedelec, P. (Copernicus Publications, 2010)
      We combine CO column measurements from the MOPITT, AIRS, SCIAMACHY, and TES satellite instruments in a full-year (May 2004-April 2005) global inversion of CO sources at 4 degrees x 5 degrees spatial resolution and monthly ...
    • NSF Year 1 Report for CTRnet: Integrated Digital Library Support for Crisis, Tragedy, and Recovery 

      Fox, Edward A.; Shoemaker, Donald J.; Sheetz, Steven D.; Kavanaugh, Andrea L.; Ramakrishnan, Naren (2010-07-08)
      The Crisis, Tragedy and Recovery network, or CTRnet, is a human and digital library network for providing a range of services relating to different kinds of tragic events. Through this digital library, we will collect and ...
    • Learning probabilistic models of connectivity from multiple spike train data 

      Patnaik, Debprakash; Laxman, Srivatsan; Ramakrishnan, Naren (2010-07-20)
      Neuronal circuits or cell assemblies carry out brain function through complex coordinated firing patterns [1]. Inferring topology of neuronal circuits from simultaneously recorded spike train data is a challenging problem ...
    • Quantifying Interhospital Patient Sharing as a Mechanism for Infectious Disease Spread 

      Huang, Susan S.; Avery, Takuser R.; Song, Yeohan H.; Elkins, Kristen R.; Nguyen, Christopher C.; Nutter, Sandra K.; Nafday, Alaka. A.; Condon, Curtis J.; Chang, Michael T.; Chrest, David; Boos, John; Bobashev, Georgiy; Wheaton, William; Frank, Steven A.; Platt, Richard; Lipsitch, Marc; Bush, Robin M.; Eubank, Stephen; Burke, Donald S.; Lee, Bruce Y. (University of Chicago Press, 2010-11)
      BACKGROUND. Assessments of infectious disease spread in hospitals seldom account for interfacility patient sharing. This is particularly important for pathogens with prolonged incubation periods or carrier states. METHODS. ...
    • Aging, resistance training, and diabetes prevention. 

      Flack, Kyle D.; Davy, Kevin P.; Hulver, Matthew W.; Winett, Richard A.; Frisard, Madlyn I.; Davy, Brenda M. (2010-12-15)
      With the aging of the baby-boom generation and increases in life expectancy, the American population is growing older. Aging is associated with adverse changes in glucose tolerance and increased risk of diabetes; the ...