School of Neuroscience
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Scholarly Works, School of Neuroscience [104]
Research articles, presentations, and other scholarship
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Atypical Neurogenesis, Astrogliosis, and Excessive Hilar Interneuron Loss Are Associated with the Development of Post-Traumatic Epilepsy
(MDPI, 2023-04-25)Background: Traumatic brain injury (TBI) remains a significant risk factor for post-traumatic epilepsy (PTE). The pathophysiological mechanisms underlying the injury-induced epileptogenesis are under investigation. The ... -
Sonic hedgehog-dependent recruitment of GABAergic interneurons into the developing visual thalamus
(Elife Sciences, 2022-11)Axons of retinal ganglion cells (RGCs) play critical roles in the development of inhibitory circuits in visual thalamus. We previously reported that RGC axons signal astrocytes to induce the expression of fibroblast growth ... -
Cortical circuit-based lossless neural integrator for perceptual decision-making: A computational modeling study
(Frontiers, 2022-11)The intrinsic uncertainty of sensory information (i.e., evidence) does not necessarily deter an observer from making a reliable decision. Indeed, uncertainty can be reduced by integrating (accumulating) incoming sensory ... -
Cool and warm ionotropic receptors control multiple thermotaxes in Drosophila larvae
(Frontiers, 2022-11)Animals are continuously confronted with different rates of temperature variation. The mechanism underlying how temperature-sensing systems detect and respond to fast and slow temperature changes is not fully understood ... -
Dispositional mindfulness and its relationship to exercise motivation and experience
(Frontiers, 2022-11)Mindfulness is the psychological state of staying attuned to the present moment, without ruminating on past or future events, and allowing thoughts, feelings, or sensations to arise without judgment or attachment. Previous ... -
Pattern of Driver-Like Input onto Neurons of the Mouse Ventral Lateral Geniculate Nucleus
(Society Neuroscience, 2023-01)The ventral lateral geniculate nucleus (vLGN) is a retinorecipient region of thalamus that contributes to a num-ber of complex visual behaviors. Retinal axons that target vLGN terminate exclusively in the external subdivi-sion ... -
Complement-dependent loss of inhibitory synapses on pyramidal neurons following Toxoplasma gondii infection
(Wiley, 2023-01-23)The apicomplexan parasite Toxoplasma gondii has developed mechanisms to establish a central nervous system infection in virtually all warm-blooded animals. Acute T. gondii infection can cause neuroinflammation, encephalitis, ... -
THC and CBD: Villain versus Hero? Insights into Adolescent Exposure
(MDPI, 2023-03-09)Cannabis is the most used drug of abuse worldwide. It is well established that the most abundant phytocannabinoids in this plant are Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD). These two compounds have ... -
The Imbalance of Astrocytic Mitochondrial Dynamics Following Blast-Induced Traumatic Brain Injury
(MDPI, 2023-01-24)Mild blast-induced traumatic brain injury (bTBI) is a modality of injury that has been of major concern considering a large number of military personnel exposed to explosive blast waves. bTBI results from the propagation ... -
Pericyte heterogeneity identified by 3D ultrastructural analysis of the microvessel wall
(Frontiers, 2022-12-16)Confident identification of pericytes (PCs) remains an obstacle in the field, as a single molecular marker for these unique perivascular cells remains elusive. Adding to this challenge is the recent appreciation that PC ... -
Acutely enhancing affective state and social connection following an online dance intervention during the COVID-19 social isolation crisis
(2023-01-16)The COVID-19 pandemic has forced many throughout the world to isolate themselves from their respective communities to stop the spread of disease. Although this form of distancing can prevent the contraction of a virus, it ... -
Neurocognitive and radiological changes after cranial radiation therapy in humans and rodents: a systematic review
(Taylor & Francis, 2022-05-24)Background: Radiation-induced brain injury is a common long-term side effect for brain cancer survivors, leading to a reduced quality of life. Although there is growing research pertaining to this topic, the relationship ... -
Hexameric Aggregation Nucleation Core Sequences and Diversity of Pathogenic Tau Strains
(MDPI, 2022-12-19)Tau aggregation associates with multiple neurodegenerative diseases including Alzheimer’s disease and rare tauopathies such as Pick’s disease, progressive supranuclear palsy, and corticobasal degeneration. The ... -
Healing minds, moving bodies: measuring the mental health effects of online dance during the COVID-19 pandemic
(Routledge, 2022-06)Use of breath, close physical proximity, and tactile cues are some of the unique facets of dance training. In March of 2020, as COVID-19 lockdowns occurred, these aspects were removed from the lexicon of dance educators ... -
Brain-Derived Neurotrophic Factor Inhibits the Function of Cation-Chloride Cotransporter in a Mouse Model of Viral Infection-Induced Epilepsy
(Frontiers, 2022-07-08)Well over 100 different viruses can infect the brain and cause brain inflammation. In the developing world, brain inflammation is a leading cause for epilepsy and often refractory to established anti-seizure drugs. Epilepsy ... -
Monocyte proinflammatory phenotypic control by ephrin type A receptor 4 mediates neural tissue damage
(American Society for Clinical Investigation, 2022-08-08)Circulating monocytes have emerged as key regulators of the neuroinflammatory milieu in a number of neuropathological disorders. Ephrin type A receptor 4 (Epha4) receptor tyrosine kinase, a prominent axon guidance molecule, ... -
Recruitment and inhibitory action of hippocampal axo-axonic cells during behavior
(Cell Press, 2021-12-01)The axon initial segment of hippocampal pyramidal cells is a key subcellular compartment for action potential generation, under GABAergic control by the "chandelier"or axo-axonic cells (AACs). Although AACs are the only ... -
Supratentorial Cortical Ependymoma: A Systematic Literature Review and Case Illustration
(SAGE, 2022-06-01)Cortical ependymomas are currently not considered a subgroup of supratentorial ependymomas; however, there is a growing body of literature investigating the natural history of these lesions compared to supratentorial ... -
Sulfasalazine decreases astrogliosis-mediated seizure burden
(Wiley, 2022-04)Objective Previously, we reported that inhibition of the astrocytic cystine/glutamate antiporter system xc- (SXC), using sulfasalazine (SAS), decreased evoked excitatory signaling in three distinct hyperexcitability models ... -
Metabolic Enzyme Alterations and Astrocyte Dysfunction in a Murine Model of Alexander Disease With Severe Reactive Gliosis
(Elsevier, 2021-11-20)The article contains the first whole brain proteomic survey from a mouse model of Alexander disease (AxD). Several novel findings include activation of the PPAR signaling pathway, which has been reported to be protective ...
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