Browsing Scholarly Works, School of Neuroscience by Title
Now showing items 1-20 of 37
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A developmental sex difference in hippocampal neurogenesis is mediated by endogenous Oestradiol
(BMC, 2010)Background: Oestradiol is a steroid hormone that exerts extensive influence on brain development and is a powerful modulator of hippocampal structure and function. The hippocampus is a critical brain region regulating ... -
Adenosine Signaling through A1 Receptors Inhibits Chemosensitive Neurons in the Retrotrapezoid Nucleus
(Society for Neuroscience, 2018)A subset of neurons in the retrotrapezoid nucleus (RTN) function as respiratory chemoreceptors by regulating depth and frequency of breathing in response to changes in tissue CO2/H. The activity of chemosensitive RTN neurons ... -
Altered peripheral immune profiles in treatment-resistant depression: response to ketamine and prediction of treatment outcome.
A subset of patients with depression have elevated levels of inflammatory cytokines, and some studies demonstrate interaction between inflammatory factors and treatment outcome. However, most studies focus on only a narrow ... -
Astrocyte morphogenesis is dependent on BDNF signaling via astrocytic TrkB.T1
(2019-08-21)Brain-derived neurotrophic factor (BDNF) is a critical growth factor involved in the maturation of the CNS, including neuronal morphology and synapse refinement. Herein, we demonstrate astrocytes express high levels of ... -
Case study on the use of intensive pediatric neurorehabilitation in the treatment of kernicterus
(2020-02-03)Background Kernicterus Spectrum Disorder (KSD) is the result of prolonged bilirubin toxicity resulting in widespread neurological injury. Once the bilirubin levels are normalized the encephalopathy becomes static, however ... -
Differential stress induced c-Fos expression and identification of region-specific miRNA-mRNA networks in the dorsal raphe and amygdala of high-responder/low-responder rats
(2017-02)Chronic stress triggers a variety of physical and mental health problems, and how individuals 2 cope with stress influences risk for emotional disorders. To investigate molecular mechanisms 3 underlying distinct stress ... -
Divergent age-dependent peripheral immune transcriptomic profile following traumatic brain injury
(Springer Nature, 2019-06-12)The peripheral immune system is a major regulator of the pathophysiology associated with traumatic brain injury (TBI). While age-at-injury influences recovery from TBI, the differential effects on the peripheral immune ... -
Dual color optogenetic control of neural populations using low-noise, multishank optoelectrodes
(Nature, 2018)Optogenetics allows for optical manipulation of neuronal activity and has been increasingly combined with intracellular and extracellular electrophysiological recordings. Genetically-identified classes of neurons are ... -
Estrogen receptor α drives pro-resilient transcription in mouse models of depression
(Nature Publishing Group, 2018-03-16)Most people exposed to stress do not develop depression. Animal models have shown that stress resilience is an active state that requires broad transcriptional adaptations, but how this homeostatic process is regulated ... -
Frontal beta-theta network during REM sleep
(eLife Sciences Publications, 2017-01-25)We lack detailed knowledge about the spatio-temporal physiological signatures of REM sleep, especially in humans. By analyzing intracranial electrode data from humans, we demonstrate for the first time that there are ... -
Functional changes in glutamate transporters and astrocyte biophysical properties in a rodent model of focal cortical dysplasia
(Frontiers, 2014-12-17)Cortical dysplasia is associated with intractable epilepsy and developmental delay in young children. Recent work with the rat freeze-induced focal cortical dysplasia (FCD) model has demonstrated that hyperexcitability in ... -
Genetic predisposition to high anxiety- and depression-like behavior coincides with diminished DNA methylation in the adult rat amygdala.
(2017-03-01)Understanding biological mechanisms that shape vulnerability to emotional dysfunction is critical for elucidating the neurobiology of psychiatric illnesses like anxiety and depression. To elucidate molecular and epigenetic ... -
Glial Dysfunction in MeCP2 Deficiency Models: Implications for Rett Syndrome
(MDPI, 2019-08-05)Rett syndrome (RTT) is a rare, X-linked neurodevelopmental disorder typically affecting females, resulting in a range of symptoms including autistic features, intellectual impairment, motor deterioration, and autonomic ... -
GluR2 endocytosis-dependent protein degradation in the amygdala mediates memory updating
(Springer Nature, 2019-03-26)Associations learned during Pavlovian fear conditioning are rapidly acquired and long lasting, providing an ideal model for studying long-term memory formation, storage, and retrieval. During retrieval, these memories can ... -
Identifying Transcriptional Regulatory Modules Among Different Chromatin States in Mouse Neural Stem Cells
(Frontiers, 2019-01-15)Gene expression regulation is a complex process involving the interplay between transcription factors and chromatin states. Significant progress has been made toward understanding the impact of chromatin states on gene ... -
Inferring and validating mechanistic models of neural microcircuits based on spike-train data
(Springer Nature, 2019-10-30)The interpretation of neuronal spike train recordings often relies on abstract statistical models that allow for principled parameter estimation and model selection but provide only limited insights into underlying ... -
Inferring and validating mechanistic models of neural microcircuits based on spike-train data
(Virginia Tech, 2018-02-07)The interpretation of neuronal spike train recordings often relies on abstract statistical models that allow for principled parameter estimation and model selection but provide only limited insights into underlying ... -
Intracranial Squamous Cell Carcinoma Arising From a Cerebellopontine Angle Epidermoid Cyst Remnant Four Decades After Partial Resection
(Frontiers, 2019-07-30)Intracranial epidermoid cysts are benign lesions that typically remain asymptomatic; however, although histopathologically benign, these cysts can rarely undergo malignant transformation into squamous cell carcinoma. Primary ... -
The Ionotropic Receptors IR21a and IR25a mediate cool sensing in Drosophila
(eLife Sciences Publications, 2016-04-29)Animals rely on highly sensitive thermoreceptors to seek out optimal temperatures, but the molecular mechanisms of thermosensing are not well understood. The Dorsal Organ Cool Cells (DOCCs) of the Drosophila larva are a ...
