Browsing Faculty Works, School of Neuroscience by Title
Now showing items 1-20 of 26
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A developmental sex difference in hippocampal neurogenesis is mediated by endogenous Oestradiol
(BMC, 2010)Background: Oestradiol is a steroid hormone that exerts extensive influence on brain development and is a powerful modulator of hippocampal structure and function. The hippocampus is a critical brain region regulating ... -
Adenosine Signaling through A1 Receptors Inhibits Chemosensitive Neurons in the Retrotrapezoid Nucleus
(Society for Neuroscience, 2018)A subset of neurons in the retrotrapezoid nucleus (RTN) function as respiratory chemoreceptors by regulating depth and frequency of breathing in response to changes in tissue CO2/H. The activity of chemosensitive RTN neurons ... -
Altered peripheral immune profiles in treatment-resistant depression: response to ketamine and prediction of treatment outcome.
A subset of patients with depression have elevated levels of inflammatory cytokines, and some studies demonstrate interaction between inflammatory factors and treatment outcome. However, most studies focus on only a narrow ... -
Differential stress induced c-Fos expression and identification of region-specific miRNA-mRNA networks in the dorsal raphe and amygdala of high-responder/low-responder rats
(2017-02)Chronic stress triggers a variety of physical and mental health problems, and how individuals 2 cope with stress influences risk for emotional disorders. To investigate molecular mechanisms 3 underlying distinct stress ... -
Divergent age-dependent peripheral immune transcriptomic profile following traumatic brain injury
(Springer Nature, 2019-06-12)The peripheral immune system is a major regulator of the pathophysiology associated with traumatic brain injury (TBI). While age-at-injury influences recovery from TBI, the differential effects on the peripheral immune ... -
Dual color optogenetic control of neural populations using low-noise, multishank optoelectrodes
(Nature, 2018)Optogenetics allows for optical manipulation of neuronal activity and has been increasingly combined with intracellular and extracellular electrophysiological recordings. Genetically-identified classes of neurons are ... -
Estrogen receptor α drives pro-resilient transcription in mouse models of depression
(Nature Publishing Group, 2018-03-16)Most people exposed to stress do not develop depression. Animal models have shown that stress resilience is an active state that requires broad transcriptional adaptations, but how this homeostatic process is regulated ... -
Frontal beta-theta network during REM sleep
(eLife Sciences Publications, 2017-01-25)We lack detailed knowledge about the spatio-temporal physiological signatures of REM sleep, especially in humans. By analyzing intracranial electrode data from humans, we demonstrate for the first time that there are ... -
Functional changes in glutamate transporters and astrocyte biophysical properties in a rodent model of focal cortical dysplasia
(Frontiers, 2014-12-17)Cortical dysplasia is associated with intractable epilepsy and developmental delay in young children. Recent work with the rat freeze-induced focal cortical dysplasia (FCD) model has demonstrated that hyperexcitability in ... -
Genetic predisposition to high anxiety- and depression-like behavior coincides with diminished DNA methylation in the adult rat amygdala.
(2017-03-01)Understanding biological mechanisms that shape vulnerability to emotional dysfunction is critical for elucidating the neurobiology of psychiatric illnesses like anxiety and depression. To elucidate molecular and epigenetic ... -
Glial Dysfunction in MeCP2 Deficiency Models: Implications for Rett Syndrome
(MDPI, 2019-08-05)Rett syndrome (RTT) is a rare, X-linked neurodevelopmental disorder typically affecting females, resulting in a range of symptoms including autistic features, intellectual impairment, motor deterioration, and autonomic ... -
GluR2 endocytosis-dependent protein degradation in the amygdala mediates memory updating
(Springer Nature, 2019-03-26)Associations learned during Pavlovian fear conditioning are rapidly acquired and long lasting, providing an ideal model for studying long-term memory formation, storage, and retrieval. During retrieval, these memories can ... -
Inferring and validating mechanistic models of neural microcircuits based on spike-train data
(Virginia Tech, 2018-02-07)The interpretation of neuronal spike train recordings often relies on abstract statistical models that allow for principled parameter estimation and model selection but provide only limited insights into underlying ... -
The Ionotropic Receptors IR21a and IR25a mediate cool sensing in Drosophila
(eLife Sciences Publications, 2016-04-29)Animals rely on highly sensitive thermoreceptors to seek out optimal temperatures, but the molecular mechanisms of thermosensing are not well understood. The Dorsal Organ Cool Cells (DOCCs) of the Drosophila larva are a ... -
MeCP2 Deficiency Leads to Loss of Glial Kir4.1
(Society for Neuroscience, 2018)Rett syndrome is a devastating neurodevelopmental disorder that affects 1 in 10,000–25,000 females. Mutations in methyl-CpG-binding protein 2 (MeCP2), a transcriptional regulator, are responsible for >95% of RTT cases. ... -
Mutual action by Gγ and Gβ for optimal activation of GIRK channels in a channel subunit-specific manner
(Nature Publishing Group, 2019-01-24)The tetrameric G protein-gated K+ channels (GIRKs) mediate inhibitory effects of neurotransmitters that activate Gi/o-coupled receptors. GIRKs are activated by binding of the Gβγ dimer, via contacts with Gβ. Gγ underlies ... -
Neonatal maternal separation stress elicits lasting DNA methylation changes in the hippocampus of stress-reactive Wistar Kyoto rats
(Wiley-Blackwell, 2016-11-01)Early-life stress (ELS) can alter neurodevelopment in variable ways, ranging from producing deleterious outcomes to stress resilience. While most ELS studies focus on its harmful effects, recent work by our lab and others ... -
Novel Applications of Magnetic Cell Sorting to Analyze Cell-Type Specific Gene and Protein Expression in the Central Nervous System
(PLOS, 2016-02-26)The isolation and study of cell-specific populations in the central nervous system(CNS) has gained significant interest in the neuroscience community. The ability to examine cell-specific gene and protein expression patterns ... -
Perineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy
(Springer Nature, 2018-11-09)Brain tumor patients commonly present with epileptic seizures. We show that tumor-associated seizures are the consequence of impaired GABAergic inhibition due to an overall loss of peritumoral fast spiking interneurons ...
