Browsing Scholarly Works, School of Neuroscience by Title
Now showing items 1-20 of 95
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Acutely enhancing affective state and social connection following an online dance intervention during the COVID-19 social isolation crisis
(2023-01-16)The COVID-19 pandemic has forced many throughout the world to isolate themselves from their respective communities to stop the spread of disease. Although this form of distancing can prevent the contraction of a virus, it ... -
Adenosine Signaling through A1 Receptors Inhibits Chemosensitive Neurons in the Retrotrapezoid Nucleus
(Society for Neuroscience, 2018)A subset of neurons in the retrotrapezoid nucleus (RTN) function as respiratory chemoreceptors by regulating depth and frequency of breathing in response to changes in tissue CO2/H. The activity of chemosensitive RTN neurons ... -
Age, but Not Sex, Modulates Foxp3 Expression in the Rat Brain across Development
(Elsevier, 2020)The interconnectivity between brain development and the immune system has become an area of interest for many neuroscientists. However, to date, a limited number of known immune mediators of the peripheral nervous system ... -
Age-Related Intrinsic Functional Connectivity Changes of Locus Coeruleus from Childhood to Older Adults
(MDPI, 2021-11-10)The locus coeruleus is critical for selective information processing by modulating the brain’s connectivity configuration. Increasingly, studies have suggested that LC controls sensory inputs at the sensory gating stage. ... -
Altered peripheral immune profiles in treatment-resistant depression: response to ketamine and prediction of treatment outcome.
(2017-03-21)A subset of patients with depression have elevated levels of inflammatory cytokines, and some studies demonstrate interaction between inflammatory factors and treatment outcome. However, most studies focus on only a narrow ... -
Assessment of Ketamine and Its Enantiomers in an Organophosphate-Based Rat Model for Features of Gulf War Illness
(MDPI, 2020-06-30)Approximately 33% of U.S. soldiers from the first Gulf War suffer from a multi-system disorder known as the Gulf War Illness (GWI). GW veterans suffer from a cluster of symptoms that prominently include fatigue and can ... -
Astrocyte morphogenesis is dependent on BDNF signaling via astrocytic TrkB.T1
(2019-08-21)Brain-derived neurotrophic factor (BDNF) is a critical growth factor involved in the maturation of the CNS, including neuronal morphology and synapse refinement. Herein, we demonstrate astrocytes express high levels of ... -
Brain-Derived Neurotrophic Factor Inhibits the Function of Cation-Chloride Cotransporter in a Mouse Model of Viral Infection-Induced Epilepsy
(Frontiers, 2022-07-08)Well over 100 different viruses can infect the brain and cause brain inflammation. In the developing world, brain inflammation is a leading cause for epilepsy and often refractory to established anti-seizure drugs. Epilepsy ... -
Building Interdisciplinary Partnerships for Community-Engaged Environmental Health Research in Appalachian Virginia
(MDPI, 2020-03-05)This article describes a collaboration among a group of university faculty, undergraduate students, local governments, local residents, and U.S. Army staff to address long-standing concerns about the environmental health ... -
Case study on the use of intensive pediatric neurorehabilitation in the treatment of kernicterus
(2020-02-03)Background Kernicterus Spectrum Disorder (KSD) is the result of prolonged bilirubin toxicity resulting in widespread neurological injury. Once the bilirubin levels are normalized the encephalopathy becomes static, however ... -
A cell–ECM mechanism for connecting the ipsilateral eye to the brain
(National Academy of Sciences, 2021-10-15)Information about features in the visual world is parsed by circuits in the retina and is then transmitted to the brain by distinct subtypes of retinal ganglion cells (RGCs). Axons from RGC subtypes are stratified in ... -
Central Taurine Attenuates Hyperthermia and Isolation Stress Behaviors Augmented by Corticotropin-Releasing Factor with Modifying Brain Amino Acid Metabolism in Neonatal Chicks
(MDPI, 2022-01-16)The objective of this study was to determine the effects of centrally administered taurine on rectal temperature, behavioral responses and brain amino acid metabolism under isolation stress and the presence of co-injected ... -
Chronic stress and adipose tissue in the anorexic state: endocrine and epigenetic mechanisms
(Taylor & Francis, 2020)Although adipose tissue metabolism in obesity has been widely studied, there is limited research on the anorexic state, where the endocrine system is disrupted by reduced adipose tissue mass and there are depot-specific ... -
Chronic stress, epigenetics, and adipose tissue metabolism in the obese state
(2020-10-19)In obesity, endocrine and metabolic perturbations, including those induced by chronic activation of the hypothalamus–pituitary–adrenal axis, are associated with the accumulation of adipose tissue and inflammation. Such ... -
A Collision Coupling Model Governs the Activation of Neuronal GIRK1/2 Channels by Muscarinic-2 Receptors
(2020-08-12)The G protein-activated Inwardly Rectifying K+-channel (GIRK) modulates heart rate and neuronal excitability. Following G-Protein Coupled Receptor (GPCR)-mediated activation of heterotrimeric G proteins (G alpha beta gamma), ... -
Corticotropin-Releasing Factor Receptor-1 Neurons in the Lateral Amygdala Display Selective Sensitivity to Acute and Chronic Ethanol Exposure
(2020-03)The lateral amygdala (LA) serves as the point of entry for sensory information within the amygdala complex, a structure that plays a critical role in emotional processes and has been implicated in alcohol use disorders. ... -
A developmental sex difference in hippocampal neurogenesis is mediated by endogenous Oestradiol
(BMC, 2010)Background: Oestradiol is a steroid hormone that exerts extensive influence on brain development and is a powerful modulator of hippocampal structure and function. The hippocampus is a critical brain region regulating ... -
Differential stress induced c-Fos expression and identification of region-specific miRNA-mRNA networks in the dorsal raphe and amygdala of high-responder/low-responder rats
(2017-02)Chronic stress triggers a variety of physical and mental health problems, and how individuals 2 cope with stress influences risk for emotional disorders. To investigate molecular mechanisms 3 underlying distinct stress ... -
Divergent age-dependent peripheral immune transcriptomic profile following traumatic brain injury
(Springer Nature, 2019-06-12)The peripheral immune system is a major regulator of the pathophysiology associated with traumatic brain injury (TBI). While age-at-injury influences recovery from TBI, the differential effects on the peripheral immune ... -
Diverse GABAergic neurons organize into subtype-specific sublaminae in the ventral lateral geniculate nucleus
(Wiley, 2020-05-19)In the visual system, retinal axons convey visual information from the outside world to dozens of distinct retinorecipient brain regions and organize that information at several levels, including either at the level of ...
