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dc.contributor.authorZhu, Lushaen
dc.contributor.authorWalsh, Danielen
dc.contributor.authorHsu, Mingen
dc.description.abstractSocial and decision-making deficits are often the first symptoms of a striking number of neurodegenerative disorders associated with aging.These includes not only disorders that directly impact dopamine and basal ganglia, such as Parkinson’s disorder, but also degeneration in which multiple neural pathways are affected over the course of normal aging. The impact of such deficits can be dramatic, as in cases of financial fraud, which disproportionately affect the elderly. Unlike memory and motor impairments, however, which are readily recognized as symptoms of more serious underlying neurological conditions, social and decision-making deficits often do not elicit comparable concern in the elderly. Furthermore, few behavioral measures exist to quantify these deficits, due in part to our limited knowledge of the core cognitive components or their neurobiological substrates. Here we probe age-related differences in decision-making using a game theory paradigm previously shown to dissociate contributions of basal ganglia and prefrontal regions to behavior. Combined with computational modeling, we provide evidence that age-related changes in elderly participants are driven primarily by an over-reliance in trial-and-error reinforcement learning that does not take into account the strategic context, which may underlie cognitive deficits that contribute to social vulnerability in elderly individuals.en
dc.description.sponsorshipThis research was supported by the Risk Management Institute and a CEDA Pilot grant from the University of California, Berkeley (Ming Hsu).en
dc.format.extent7 pagesen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.subjectgame theoryen
dc.subjectreinforcement learningen
dc.subjectstrategic learningen
dc.subjectdecision neuroscienceen
dc.titleNeuroeconomic measures of social decision-making across the lifespanen
dc.typeArticle - Refereeden
dc.title.serialFrontiers In Neuroscienceen

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Creative Commons Attribution 4.0 International
License: Creative Commons Attribution 4.0 International