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dc.contributor.authorAlexander, Georgia M.en
dc.contributor.authorFarris, Shannonen
dc.contributor.authorPirone, Jason R.en
dc.contributor.authorZheng, Chenguangen
dc.contributor.authorColgin, Laura L.en
dc.contributor.authorDudek, Serena M.en
dc.identifier.citationAlexander, G. M. et al. Social and novel contexts modify hippocampal CA2 representations of space. Nat. Commun. 7:10300 doi: 10.1038/ncomms10300 (2016).en
dc.description.abstractThe hippocampus supports a cognitive map of space and is critical for encoding declarative memory (who, what, when and where). Recent studies have implicated hippocampal subfield CA2 in social and contextual memory but how it does so remains unknown. Here we find that in adult male rats, presentation of a social stimulus (novel or familiar rat) or a novel object induces global remapping of place fields in CA2 with no effect on neuronal firing rate or immediate early gene expression. This remapping did not occur in CA1, suggesting this effect is specific for CA2. Thus, modification of existing spatial representations might be a potential mechanism by which CA2 encodes social and novel contextual information.en
dc.description.sponsorshipThis research is supported by the Intramural Research Program of the U.S. National Institutes of Health, NIEHS (Z01 ES100221 to S.M.D.), as well as grant number 1R01MH102450-01A1 from NIMH (to L.L.C.) and Office of Naval Research Young Investigator award N00014-14-1-0322 (to L.L.C.).en
dc.format.extent14 pagesen
dc.publisherSpringer Communicationsen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.titleSocial and novel contexts modify hippocampal CA2 representations of spaceen
dc.typeArticle - Refereeden
dc.title.serialNature Communicationsen

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Creative Commons Attribution 4.0 International
License: Creative Commons Attribution 4.0 International