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Protein Arginine Deiminase 2 Binds Calcium in an Ordered Fashion: Implications for Inhibitor Design
(Amer Chemical Soc, 2015-04-01)
Protein arginine deiminases (PADs) are calcium-dependent histone-modifying enzymes whose activity is dysregulated in inflammatory diseases and cancer. PAD2 functions as an Estrogen Receptor (ER) coactivator in breast cancer ...
Crystal structure of the MACPF domain of human complement protein C8 alpha in complex with the C8 gamma subunit
(Academic Press Ltd Elsevier Science Ltd, 2008-05-29)
Human C8 is one of five complement components (C5b, C6, C7, C8 and C9) that assemble on bacterial membranes to form a pore-like structure referred to as the "membrane attack complex" (MAC). C8 contains three genetically ...