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  • NLRX1 Is a Multifaceted and Enigmatic Regulator of Immune System Function 

    Nagai-Singer, Margaret A.; Morrison, Holly A.; Allen, Irving C. (2019-10-11)
    Over the last decade, significant progress has been achieved in defining mechanisms underlying NLR regulation of immune system function. However, several NLR family members continue to defy our best attempts at characterization ...
  • Drug-Susceptible and Multidrug-Resistant Mycobacterium tuberculosis in a Single Patient 

    Baffoe-Bonnie, Anthony; Houpt, Eric R.; Turner, Lauren; Dodge, Denise; Heysell, Scott K. (2019-11)
    A patient who had initial infection with mixed strains of drug-susceptible and multidrug-resistant tuberculosis was presumed to have acquired drug resistance before confirmation that sequential strains were genotypically ...
  • Multimodal Imaging of Nonenhancing Glioblastoma Regions 

    John, Flora; Robinette, Natasha L.; Amit-Yousif, Alit J.; Bosnyak, Edit; Barger, Geoffrey R.; Shah, Keval D.; Mittal, Sandeep; Juhasz, Csaba (2019-11-13)
    Background: Clinical glioblastoma treatment mostly focuses on the contrast-enhancing tumor mass. Amino acid positron emission tomography (PET) can detect additional, nonenhancing glioblastoma-infiltrated brain regions that ...
  • Fabrication and characterization of PLGA nanoparticles encapsulating large CRISPR–Cas9 plasmid 

    Jo, Ami; Ringel-Scaia, Veronica M.; McDaniel, Dylan K.; Thomas, Cassidy A.; Zhang, Rui; Riffle, Judy S.; Allen, Irving C.; Davis, Richey M. (2020-01-20)
    Abstract Background The clustered regularly interspaced short palindromic repeats (CRISPR) and Cas9 protein system is a revolutionary tool for gene therapy. Despite promising reports of the utility of CRISPR–Cas9 for in ...
  • Laparoscopic repair of interparietal abdominal wall hernias 

    Kalmar, Christopher L.; Bower, Curtis E. (Oxford University Press, 2019-10-01)
    Interparietal hernias are rare abdominal defects where intraabdominal contents protrude between layers of the abdominal wall. There is limited experience using laparoscopic technique for repairing substantially large ...
  • Spectral characteristics of urine specimens from healthy human volunteers analyzed using Raman chemometric urinalysis (Rametrix) 

    Senger, Ryan S.; Kavuru, Varun; Sullivan, Meaghan; Gouldin, Austin; Lundgren, Stephanie; Merrifield, Kristen; Steen, Caitlin; Baker, Emily; Vu, Tommy; Agnor, Ben; Martinez, Gabrielle; Coogan, Hannah; Carswell, William; Karageorge, Lampros; Dev, Devasmita; Du, Pang; Sklar, Allan; Orlando, Giuseppe; Pirkle, James, Jr.; Robertson, John L. (PLOS, 2019-09-27)
    Raman chemometric urinalysis (Rametrix™) was used to analyze 235 urine specimens from healthy individuals. The purpose of this study was to establish the “range of normal” for Raman spectra of urine specimens from healthy ...
  • Simultaneous involvement of optic and abducens nerves by Lyme disease: Case report with review of the literature 

    Dabiri, Iman; Burakgazi, Ahmet Z. (PAGEPress, 2019)
    Ocular manifestations of Lyme disease (LD) remain a rare feature of the disease, but it may present a wide range of clinical presentations with different combinations. LD related optic neuritis or cranial nerve (CN) six ...
  • Atypical presentation of Lyme neuroborreliosis related meningitis and radiculitis 

    Dabiri, Iman; Calvo, Nicholas; Nauman, Feryal; Pahlavanzadeh, Mahsa; Burakgazi, Ahmet Z. (PAGEPress, 2019-10-11)
    Lyme disease related central and peripheral nervous system manifestations can occur in isolation or together. Radiculitis or inflammation of the nerve root can be seen 3-5% of the time in acute neuroborreliosis affecting ...
  • Diagnosis and Treatment of a Benign Pediatric Mandible Tumor 

    Joy, Matthew T.; Liao, Christopher D.; Magdycz, William P.; Parulis, Albert W.; Thompson, James D. (Ovid Technologies, 2019-10-15)
    Pediatric mandible tumors are rare and generally benign but can be locally aggressive. Diagnosis and treatment involve tumor identification, excision, and subsequent reconstruction. Successful reconstruction should address ...
  • Faculty Resources for Educational Excellence (FREE) Newsletter, December 2019 

    Unknown author (Virginia Tech Carilion School of Medicine, 2019-12)
    This newsletter focuses each month on some aspect of faculty development, including tips, resources and various opportunities designed to support faculty success at the Virginia Tech Carilion School of Medicine. In this ...
  • Faculty Resources for Educational Excellence (FREE) Newsletter, November 2019 

    Unknown author (Virginia Tech Carilion School of Medicine, 2019-11)
    This newsletter focuses each month on some aspect of faculty development, including tips, resources and various opportunities designed to support faculty success at the Virginia Tech Carilion School of Medicine. In this ...
  • Metastatic Multiple Myeloma to the Skin 

    Holliday, Alex C.; Khan, Mohammed I.; Mazloom, Sean E.; Chavan, Rahul N.; Grider, Douglas J. (Hindawi, 2019-11-12)
    Cutaneous involvement of multiple myeloma (MM) is uncommon, typically occurs in late stage disease, and is a poor prognostic indicator with an approximate eight month median survival. We present a 51-year-old man with ...
  • Pancreatic Inflammatory Pseudotumor-Like Follicular Dendritic Cell Tumor 

    Mograbi, Madison; Stump, Michael S.; Luyimbazi, David T.; Shakhatreh, Mohammad H.; Grider, Douglas J. (Hindawi, 2019-12-05)
    Follicular dendritic cell sarcoma (FDCS) is a rare and underdiagnosed malignant neoplasm which characteristically presents as a solitary, slow-growing mass with no discrete symptoms. Histologically, lymphocytes and spindle ...
  • Epidermoid Cysts in a Wandering Spleen: An Unusual Enigma 

    Algino, Sarah E.; Sorrentino, Siena; Luyimbazi, David T.; Grider, Douglas J. (Hindawi, 2019-11-20)
    Epidermoid splenic cysts are rare lesions in the spleen. These cysts are characterized by a stratified squamous epithelial lining, internal septations, and calcification. Congenital in origin, epidermoid splenic cysts are ...
  • Dropped head syndrome due to neuromuscular disorders: Clinical manifestation and evaluation 

    Burakagazi, Ahmet Z.; Richardson, Perry K.; Abu-Rub, Mohammad (PAGEPress, 2019-06-18)
    In this article, we discuss the clinical approach to patients with dropped head syndrome and identify the various neuromuscular causes of dropped head syndrome including muscle, neuromuscular junction, peripheral nerve and ...
  • The development of myasthenia gravis in a patient with facioscapulohumeral muscular dystrophy: case report and literature review 

    Nauman, Feryal; Fawwad, Muhammad; Hussain, Ahmed; Burakgazi, Ahmet Z. (PAGEPress, 2019-06-10)
    The co-existence of facioscapulohumeral muscle dystrophy (FSHD) and myasthenia gravis (MG) is very rare and few cases have been described in the literature. To increase the awareness of the health care providers, we present ...
  • A Genetic System for Methanocaldococcus jannaschii: An Evolutionary Deeply Rooted Hyperthermophilic Methanarchaeon 

    Susanti, Dwi; Frazier, Mary C.; Mukhopadhyay, Biswarup (Frontiers, 2019-07-03)
    Phylogenetically deeply rooted methanogens belonging to the genus of Methanocaldococcus living in deep-sea hydrothermal vents derive energy exclusively from hydrogenotrophic methanogenesis, one of the oldest respiratory ...
  • Faculty Resources for Educational Excellence (FREE) Newsletter, October 2019 

    Unknown author (Virginia Tech Carilion School of Medicine, 2019-10)
    This newsletter focuses each month on some aspect of faculty development, including tips, resources and various opportunities designed to support faculty success at the Virginia Tech Carilion School of Medicine. In this ...
  • Formation of the Francisella tularensis Biofilm is Affected by Cell Surface Glycosylation, Growth Medium, and a Glucan Exopolysaccharide 

    Champion, Anna E.; Catanzaro, Kelly C. Freudenberger; Bandara, Aloka B.; Inzana, Thomas J. (Springer Nature, 2019-08-22)
    Biofilms are matrix-associated communities that enable bacteria to colonise environments unsuitable for free-living bacteria. The facultative intracellular pathogen Francisella tularensis can persist in water, amoebae, and ...
  • IL-12 signaling drives the differentiation and function of a T(H)1-derived T-FH1-like cell population 

    Powell, Michael D.; Read, Kaitlin A.; Sreekumar, Bharath K.; Jones, Devin M.; Oestreich, Kenneth J. (Springer Nature, 2019-09-30)
    CD4(+) T follicular helper (T-FH) cells provide help to B cells and promote antibody-mediated immune responses. Increasing evidence supports the existence of T-FH populations that secrete cytokines typically associated ...

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