Fralin Biomedical Research Institute at VTC
Browse by
The Fralin Biomedical Research Institute was named in 2019, and was formerly the Virginia Tech Carilion Research Institute.
Collections in this community
-
Institute Publications, Fralin Biomedical Research Institute at VTC [0]
Newsletters, annual reports, and other Institute publications -
Scholarly Works, Fralin Biomedical Research Institute at VTC [248]
Research articles, presentations, and other scholarship
Recent Submissions
-
The adhesion function of the sodium channel beta subunit (beta 1) contributes to cardiac action potential propagation
(2018-08-14)Computational modeling indicates that cardiac conduction may involve ephaptic coupling - intercellular communication involving electrochemical signaling across narrow extracellular clefts between cardiomyocytes. We ... -
Acetylcholine Receptor Activation as a Modulator of Glioblastoma Invasion
(MDPI, 2019-10-05)Grade IV astrocytomas, or glioblastomas (GBMs), are the most common malignant primary brain tumor in adults. The median GBM patient survival of 12–15 months has remained stagnant, in spite of treatment strategies, ... -
Modulation of gap junction-associated Cx43 in neural stem/progenitor cells following traumatic brain injury
(2017-09)Restoration of learning and memory deficits following traumatic brain injury (TBI) is attributed, in part, to enhanced neural stem/progenitor cell (NSPCs) function. Recent findings suggest gap junction (GJ)-associated ... -
High-frequency irreversible electroporation is an effective tumor ablation strategy that induces immunologic cell death and promotes systemic anti-tumor immunity
(2019-06)Background: Despite promising treatments for breast cancer, mortality rates remain high and treatments for metastatic disease are limited. High-frequency irreversible electroporation (H-FIRE) is a novel tumor ablation ... -
EGR1 recruits TET1 to shape the brain methylome during development and upon neuronal activity
(2019-08-29)Life experience can leave lasting marks, such as epigenetic changes, in the brain. How life experience is translated into storable epigenetic information remains largely unknown. With unbiased data-driven approaches, we ... -
Short-term mindfulness practice attenuates reward prediction errors signals in the brain
(Nature Research, 2019-05-06)Activity changes in dopaminergic neurons encode the ongoing discrepancy between expected and actual value of a stimulus, providing a teaching signal for a reward prediction process. Previous work comparing a cohort of ... -
Blood Vessel Patterning on Retinal Astrocytes Requires Endothelial Flt-1 (VEGFR-1)
(MDPI, 2019-09-07)Feedback mechanisms are critical components of many pro-angiogenic signaling pathways that keep vessel growth within a functional range. The Vascular Endothelial Growth Factor-A (VEGF-A) pathway utilizes the decoy VEGF-A ... -
Guidelines for experimental models of myocardial ischemia and infarction
(2018-04)Myocardial infarction is a prevalent major cardiovascular event that arises from myocardial ischemia with or without reperfusion, and basic and translational research is needed to better understand its underlying mechanisms ... -
Remote Alcohol Monitoring to Facilitate Incentive-Based Treatment for Alcohol Use Disorder: A Randomized Trial
(2018-12)B ackground: The delivery of monetary incentives contingent on verified abstinence is an effective treatment for alcohol use disorder. However, technological barriers to accurate, frequent biochemical verification of alcohol ... -
Neuroimaging, neuromodulation, and population health: the neuroscience of chronic disease prevention
(2018-09)Preventable chronic diseases are the leading cause of death in the majority of countries throughout the world, and this trend will continue for the foreseeable future. The potential to offset the social, economic, and ... -
Electrophysiologic effects of the I-K1 inhibitor PA-6 are modulated by extracellular potassium in isolated guinea pig hearts
(The Physiological Society, 2017-01)The pentamidine analog PA-6 was developed as a specific inward rectifier potassium current (I-K1) antagonist, because established inhibitors either lack specificity or have side effects that prohibit their use in vivo. We ... -
Primed for Health: Future Thinking Priming Decreases Delay Discounting
(2019-07)Objective: Delay discounting, the propensity to devalue delayed rewards, has robust predictive validity for multiple health behaviors and is a new therapeutic target for health behavior change. Priming can influence behaviors ... -
Interaction of α Carboxyl Terminus 1 Peptide With the Connexin 43 Carboxyl Terminus Preserves Left Ventricular Function After Ischemia‐Reperfusion Injury
(American Heart Association, 2019-08-19)Background α Carboxyl terminus 1 (αCT1) is a 25–amino acid therapeutic peptide incorporating the zonula occludens‐1 (ZO‐1)–binding domain of connexin 43 (Cx43) that is currently in phase 3 clinical testing on chronic ... -
Multilevel analysis of BMI growth trajectories of US school children: Features and risk factors
(Elsevier, 2019-07-17)Childhood obesity continues to be a major focus of public health efforts in the United States, where nearly 17% of children are obese. In this study, we focused on two significant features that characterize U.S. society—school ... -
Towards a Physiological Scale of Vocal Fold Agent-Based Models of Surgical Injury and Repair: Sensitivity Analysis, Calibration and Verification
(MDPI, 2019-07-25)Agent based models (ABM) were developed to numerically simulate the biological response to surgical vocal fold injury and repair at the physiological level. This study aimed to improve the representation of existing ABM ... -
Quantitative Variation in m.3243A > G Mutation Produce Discrete Changes in Energy Metabolism
(Springer Nature, 2019-04-08)Mitochondrial DNA (mtDNA) 3243A > G tRNALeu((UUR)) heteroplasmic mutation (m.3243A > G) exhibits clinically heterogeneous phenotypes. While the high mtDNA heteroplasmy exceeding a critical threshold causes mitochondrial ... -
Effect of Various OR Noise on Fine Motor Skills, Cognition, and Mood
(Hindawi, 2019-07-04)Background. The amalgam of noises inherent to the modern-day operating room has the potential of diluting surgeon concentration, which could affect surgeon performance and mood and have implications on quality of care and ... -
Applications of Ultrasound to Stimulate Therapeutic Revascularization
(MDPI, 2019-06-24)Many pathological conditions are characterized or caused by the presence of an insufficient or aberrant local vasculature. Thus, therapeutic approaches aimed at modulating the caliber and/or density of the vasculature by ... -
Opening the Debate: How to Fulfill the Need for Physicians’ Training in Circadian-Related Topics in a Full Medical School Curriculum
(Ubiquity Press, 2015)Background: Circadian rhythms are daily changes in our physiology and behavior that are manifested as patterns of brain wave activity, periodic hormone production, recurring cell regeneration, and other oscillatory biological ... -
Capturing the Biologic Onset of Inflammatory Bowel Diseases: Impact on Translational and Clinical Science
(MDPI, 2019-06-06)While much progress has been made in the last two decades in the treatment and the management of inflammatory bowel diseases (IBD)—both ulcerative colitis (UC) and Crohn’s Disease (CD)—as of today these ...
RSS 1.0