Fralin Biomedical Research Institute at VTC
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The Fralin Biomedical Research Institute was named in 2019, and was formerly the Virginia Tech Carilion Research Institute.
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Scholarly Works, Fralin Biomedical Research Institute at VTC [444]
Research articles, presentations, and other scholarship
Recent Submissions
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Mapping established psychopathology scales onto the Hierarchical Taxonomy of Psychopathology (HiTOP)
(Wiley, 2023-05)The Hierarchical Taxonomy of Psychopathology (HiTOP) organizes phenotypes of mental disorder based on empirical covariation, offering a comprehensive organizational framework from narrow symptoms to broader patterns of ... -
Development of cognitive control during adolescence: The integrative effects of family socioeconomic status and parenting behaviors
(Elsevier, 2022-10)Cognitive control is of great interest to researchers and practitioners. The concurrent association between family socioeconomic status (SES) and adolescent cognitive control is well-documented. However, little is known ... -
A Soluble Platelet-Derived Growth Factor Receptor-β Originates via Pre-mRNA Splicing in the Healthy Brain and Is Upregulated during Hypoxia and Aging
(MDPI, 2023-04-21)The platelet-derived growth factor-BB (PDGF-BB) pathway provides critical regulation of cerebrovascular pericytes, orchestrating their investment and retention within the brain microcirculation. Dysregulated PDGF Receptor-beta ... -
A Phase 1b Adaptive Androgen Deprivation Therapy Trial in Metastatic Castration Sensitive Prostate Cancer
(MDPI, 2022-11)Simple Summary Despite early utilization of new hormonal agents (NHA, i.e., abiraterone, enzalutamide and apalutamide) for combined androgen deprivation therapy (ADT) for metastatic prostate cancer, increasingly more men ... -
Tobacco use among Appalachian adolescents: An urgent need for virtual scale out of effective interventions
(European Publishing, 2022-11)Tobacco use, typically initiated during adolescence, can escalate into young adulthood, even among experimenting or intermittent users. Despite declines in cigarette smoking among US adolescents, use of other tobacco ... -
Sonic hedgehog-dependent recruitment of GABAergic interneurons into the developing visual thalamus
(Elife Sciences, 2022-11)Axons of retinal ganglion cells (RGCs) play critical roles in the development of inhibitory circuits in visual thalamus. We previously reported that RGC axons signal astrocytes to induce the expression of fibroblast growth ... -
The risks of misclassifying addictive food substances as non-addictive
(Wiley, 2023-04-01)There is evidence that the rise of ultra-processed foods has been associated with an increase in addictive eating, diet-related disease and preventable death. As with tobacco, misclassifying these food substances as ... -
Habitual daily intake of a sweet and fatty snack modulates reward processing in humans
(Elsevier, 2023-04-04)Western diets rich in fat and sugar promote excess calorie intake and weight gain; however, the underlying mechanisms are unclear. Despite a well-documented association between obesity and altered brain dopamine function, ... -
Decoding the Brain’s Surface to Track Deeper Activity
(Frontiers Media, 2022-03-17)Neural activity can be readily and non-invasively recorded from the scalp using electromagnetic and optical signals, but unfortunately all scalp-based techniques have depth-dependent sensitivities. We hypothesize, though, ... -
Inclusion of Clinicians in the Development and Evaluation of Clinical Artificial Intelligence Tools: A Systematic Literature Review
(Frontiers Media, 2022-04-07)The application of machine learning (ML) and artificial intelligence (AI) in healthcare domains has received much attention in recent years, yet significant questions remain about how these new tools integrate into frontline ... -
Validation of a novel method of ultraviolet-induced cutaneous inflammation and its associations with anhedonia
(Nature Portfolio, 2022-11)Affective immunology of the skin is a growing area; however, established protocols for measuring individual differences in cutaneous inflammation are lacking. To address this, we present a preliminary validation of Precision ... -
Dispositional mindfulness and its relationship to exercise motivation and experience
(Frontiers, 2022-11)Mindfulness is the psychological state of staying attuned to the present moment, without ruminating on past or future events, and allowing thoughts, feelings, or sensations to arise without judgment or attachment. Previous ... -
Tapping into community expertise: stakeholder engagement in the design process
(Taylor & Francis, 2022-10)The Connection to Care (C2C) project, a transdisciplinary work-in-progress, employs community-engaged participatory research and design methods at the nexus of policy adaptation and product innovations. C2C aims to advance ... -
Pattern of Driver-Like Input onto Neurons of the Mouse Ventral Lateral Geniculate Nucleus
(Society Neuroscience, 2023-01)The ventral lateral geniculate nucleus (vLGN) is a retinorecipient region of thalamus that contributes to a num-ber of complex visual behaviors. Retinal axons that target vLGN terminate exclusively in the external subdivi-sion ... -
Maternal early life stress is associated with pro-inflammatory processes during pregnancy
(Elsevier, 2023-03)Early life stress (ELS) is common in the United States and worldwide, and contributes to the development of psychopathology in individuals with these experiences and their offspring. A growing body of research suggests ... -
Long-term recovery from opioid use disorder: recovery subgroups, transition states and their association with substance use, treatment and quality of life
(Wiley, 2022-12)Background and AimsLimited information exists regarding individual subgroups of recovery from opioid use disorder (OUD) following treatment and how these subgroups may relate to recovery trajectories. We used multi-dimensional ... -
System Integrated Information
(MDPI, 2023-02)Integrated information theory (IIT) starts from consciousness itself and identifies a set of properties (axioms) that are true of every conceivable experience. The axioms are translated into a set of postulates about the ... -
Layer-specific mitochondrial diversity across hippocampal CA2 dendrites
(Wiley, 2023-02)CA2 is an understudied subregion of the hippocampus that is critical for social memory. Previous studies identified multiple components of the mitochondrial calcium uniporter (MCU) complex as selectively enriched in CA2. ... -
Complement-dependent loss of inhibitory synapses on pyramidal neurons following Toxoplasma gondii infection
(Wiley, 2023-01-23)The apicomplexan parasite Toxoplasma gondii has developed mechanisms to establish a central nervous system infection in virtually all warm-blooded animals. Acute T. gondii infection can cause neuroinflammation, encephalitis, ... -
Rate-dependent effects of narrative interventions in a longitudinal study of individuals who use alcohol
(Wiley, 2023-02-21)Background: Delay discounting (DD), the decrease in reward valuation as a function of delay to receipt, is a key process undergirding alcohol use. Narrative interventions, including episodic future thinking (EFT), have ...