Fralin Biomedical Research Institute at VTC
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The Fralin Biomedical Research Institute was named in 2019, and was formerly the Virginia Tech Carilion Research Institute.
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Scholarly Works, Fralin Biomedical Research Institute at VTC [372]
Research articles, presentations, and other scholarship
Recent Submissions
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Using a human factors-centric approach to development and testing of a face shield designed for health care workers: A COVID-19 case study for process and outcomes
(Mosby-Elsevier, 2022-03-01)Background: Face shields are a critical piece of personal protective equipment and their comfort impacts compliant use and thus protectiveness. Optimal design criteria for face shield use in healthcare environments are ... -
The leucine-NH4(+) uptake regulator Any1 limits growth as part of a general amino acid control response to loss of La protein by fission yeast
(2021-06-21)The sla1(+) gene of Schizosachharoymces pombe encodes La protein which promotes proper processing of precursor-tRNAs. Deletion of sla1 (sla1 Delta) leads to disrupted tRNA processing and sensitivity to target of rapamycin ... -
Using Zebrafish to Elucidate Glial-Vascular Interactions During CNS Development
(2021-06-29)An emerging area of interest in Neuroscience is the cellular relationship between glia and blood vessels, as many of the presumptive support roles of glia require an association with the vasculature. These interactions are ... -
Prostate-Specific Membrane Antigen as Target for Neuroimaging of Central Nervous System Tumors
(Hindawi, 2022-04-15)Introduction. Positron emission tomography (PET) imaging with prostate-specific membrane antigen- (PSMA-) binding tracers has been found incidentally to demonstrate uptake in CNS tumors. Following the encouraging findings ... -
The Non-Linear Path from Gene Dysfunction to Genetic Disease: Lessons from the MICPCH Mouse Model
(MDPI, 2022-03-28)Most human disease manifests as a result of tissue pathology, due to an underlying disease process (pathogenesis), rather than the acute loss of specific molecular function(s). Successful therapeutic strategies thus may ... -
Females, but not males, require protein degradation in the hippocampus for contextual fear memory formation
(2021-08)Strong evidence supports a role for protein degradation in fear memory formation. However, these data have been largely done in only male animals. Here, we found that following contextual fear conditioning, females, but ... -
A 4-year longitudinal neuroimaging study of cognitive control using latent growth modeling: developmental changes and brain-behavior associations
(2021-08-15)Despite theoretical models suggesting developmental changes in neural substrates of cognitive control in adolescence, empirical research has rarely examined intraindividual changes in cognitive control-related brain ... -
Opposing roles for striatonigral and striatopallidal neurons in dorsolateral striatum in consolidating new instrumental actions
(2021-08-25)Comparatively little is known about how new instrumental actions are encoded in the brain. Using whole-brain c-Fos mapping, we show that neural activity is increased in the anterior dorsolateral striatum (aDLS) of mice ... -
Emotional adaptation during a crisis: decline in anxiety and depression after the initial weeks of COVID-19 in the United States
(2021-08-20)Crises such as the COVID-19 pandemic are known to exacerbate depression and anxiety, though their temporal trajectories remain under-investigated. The present study aims to investigate fluctuations in depression and anxiety ... -
Cellular Size, Gap Junctions, and Sodium Channel Properties Govern Developmental Changes in Cardiac Conduction
(2021-10-25)Electrical conduction in cardiac ventricular tissue is regulated via sodium (Na+) channels and gap junctions (GJs). We and others have recently shown that Na(+)channels preferentially localize at the site of cell-cell ... -
Metabolic Reprogramming of Ovarian Cancer Spheroids during Adhesion
(MDPI, 2022-03-09)Ovarian cancer remains a deadly disease and its recurrence disease is due in part to the presence of disseminating ovarian cancer aggregates not removed by debulking surgery. During dissemination in a dynamic ascitic ... -
Selective disruption of trigeminal sensory neurogenesis and differentiation in a mouse model of 22q11.2 deletion syndrome
(Company of Biologists, 2022-02)22q11.2 Deletion Syndrome (22q11DS) is a neurodevelopmental disorder associated with cranial nerve anomalies and disordered oropharyngeal function, including pediatric dysphagia. Using the LgDel 22q11DS mouse model, we ... -
Fasting and postprandial trimethylamine N-oxide in sedentary and endurance-trained males following a short-term high-fat diet
(Wiley, 2021-08-01)Gut bacteria release trimethylamine (TMA) from dietary substrates. TMA is absorbed and is subsequently oxidized in the liver to produce trimethylamine N-oxide (TMAO). Plasma TMAO levels are positively correlated with risk ... -
Delivery strategies for cell-based therapies in the brain: overcoming multiple barriers
(Springer, 2021-10-30)Cell-based therapies to the brain are promising for the treatment of multiple brain disorders including neurodegeneration and cancers. In order to access the brain parenchyma, there are multiple physiological barriers that ... -
Human Breast Milk 3’-Sialyllactose Positively Associates with Language Development During Infancy
(2021)Background: Genetic polymorphisms leading to variations in human milk oligosaccharide (HMO) composition have been reported. Alpha-Tetrasaccharide (A-tetra), an HMO, has been shown to only be present (>limit of detection; ... -
Profiling nonhuman primate germline RNA to understand the legacy of early life stress
(Wiley, 2021-09-09)Exposure to stress is a risk factor for perturbed mental health, including impoverished regulation of emotional and physiological responses that accompany anxiety and mood disorders, substance abuse and behavioral disorders. ... -
Advances in Behavioral Remote Data Collection in the Home Setting: Assessing the Mother-Infant Relationship and Infant's Adaptive Behavior via Virtual Visits
(Frontiers, 2021-10-01)Psychological science is struggling with moving forward in the midst of the COVID-19 pandemic, especially due to the halting of behavioral data collection in the laboratory. Safety barriers to assessing psychological ... -
Dear reviewers: Responses to common reviewer critiques about infant neuroimaging studies
(Elsevier, 2022-02-01)The field of adult neuroimaging relies on well-established principles in research design, imaging sequences, processing pipelines, as well as safety and data collection protocols. The field of infant magnetic resonance ... -
Designing Patient-Driven, Tissue-Engineered Models of Primary and Metastatic Breast Cancer
(MDPI, 2022-01-18)The rising survival rate for early-stage breast cancer in the United States has created an expanding population of women in remission at risk for distant recurrence, with metastatic spread to the brain demonstrating an ...
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