Fralin Biomedical Research Institute at VTC
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The Fralin Biomedical Research Institute was named in 2019, and was formerly the Virginia Tech Carilion Research Institute.
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Institute Publications, Fralin Biomedical Research Institute at VTC [0]
Newsletters, annual reports, and other Institute publications -
Scholarly Works, Fralin Biomedical Research Institute at VTC [235]
Research articles, presentations, and other scholarship
Recent Submissions
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Multilevel analysis of BMI growth trajectories of US school children: Features and risk factors
(Elsevier, 2019-07-17)Childhood obesity continues to be a major focus of public health efforts in the United States, where nearly 17% of children are obese. In this study, we focused on two significant features that characterize U.S. society—school ... -
Towards a Physiological Scale of Vocal Fold Agent-Based Models of Surgical Injury and Repair: Sensitivity Analysis, Calibration and Verification
(MDPI, 2019-07-25)Agent based models (ABM) were developed to numerically simulate the biological response to surgical vocal fold injury and repair at the physiological level. This study aimed to improve the representation of existing ABM ... -
Quantitative Variation in m.3243A > G Mutation Produce Discrete Changes in Energy Metabolism
(Springer Nature, 2019-04-08)Mitochondrial DNA (mtDNA) 3243A > G tRNALeu((UUR)) heteroplasmic mutation (m.3243A > G) exhibits clinically heterogeneous phenotypes. While the high mtDNA heteroplasmy exceeding a critical threshold causes mitochondrial ... -
Effect of Various OR Noise on Fine Motor Skills, Cognition, and Mood
(Hindawi, 2019-07-04)Background. The amalgam of noises inherent to the modern-day operating room has the potential of diluting surgeon concentration, which could affect surgeon performance and mood and have implications on quality of care and ... -
Applications of Ultrasound to Stimulate Therapeutic Revascularization
(MDPI, 2019-06-24)Many pathological conditions are characterized or caused by the presence of an insufficient or aberrant local vasculature. Thus, therapeutic approaches aimed at modulating the caliber and/or density of the vasculature by ... -
Opening the Debate: How to Fulfill the Need for Physicians’ Training in Circadian-Related Topics in a Full Medical School Curriculum
(Ubiquity Press, 2015)Background: Circadian rhythms are daily changes in our physiology and behavior that are manifested as patterns of brain wave activity, periodic hormone production, recurring cell regeneration, and other oscillatory biological ... -
Capturing the Biologic Onset of Inflammatory Bowel Diseases: Impact on Translational and Clinical Science
(MDPI, 2019-06-06)While much progress has been made in the last two decades in the treatment and the management of inflammatory bowel diseases (IBD)—both ulcerative colitis (UC) and Crohn’s Disease (CD)—as of today these ... -
Target-Derived Matricryptins Organize Cerebellar Synapse Formation through _3_1 Integrins
(Cell, 2012)Trans-synaptic organizing cues must be passed between synaptic partners for synapses to properly form. Much of our understanding of this process stems from studies at the neuromuscular junction, where target-derived growth ... -
Social and novel contexts modify hippocampal CA2 representations of space
(Springer Communications, 2016-01-25)The hippocampus supports a cognitive map of space and is critical for encoding declarative memory (who, what, when and where). Recent studies have implicated hippocampal subfield CA2 in social and contextual memory but how ... -
School-level disadvantage and failed cessation treatment among adolescent smokers
(EU European Publishing, 2018)INTRODUCTION While understanding factors that lead to successful adolescent smoking cessation outcomes is necessary, it is also prudent to determine factors and conditions that contribute to failure to quit smoking. The ... -
Hippocampal Deletion of BDNF Gene Attenuates Gamma Oscillations in Area CA1 by Up-Regulating 5-HT3 Receptor
(PLOS, 2011-01-26)Background: Pyramidal neurons in the hippocampal area CA3 express high levels of BDNF, but how this BDNF contributes to oscillatory properties of hippocampus is unknown. Methodology/Principal Findings: Here we examined ... -
Functional Blockade of Small GTPase RAN Inhibits Glioblastoma Cell Viability
(Frontiers, 2019-01-08)Glioblastoma, the most common malignant tumor in the brain, lacks effective treatments and is currently incurable. To identify novel drug targets for this deadly cancer, the publicly available results of RNA interference ... -
Developing a dissemination model to improve intervention reach among West Virginia youth smokers
(Frontiers, 2014-08-01)The not-on-tobacco program is an evidence-based teen smoking cessation program adopted by the American Lung Association (ALA). Although widely disseminated nationally via ALA Master Trainers, in recent years, adoption and ... -
X-linked intellectual disability gene CASK regulates postnatal brain growth in a non-cell autonomous manner
(BMC, 2016-03-31)The phenotypic spectrum among girls with heterozygous mutations in the X-linked intellectual disability (XLID) gene CASK (calcium/calmodulin-dependent serine protein kinase) includes postnatal microcephaly, ponto-cerebellar ... -
Mathematically Gifted Adolescents Have Deficiencies in Social Valuation and Mentalization
(PLOS, 2011-04-04)Many mathematically gifted adolescents are characterized as being indolent, underachieving and unsuccessful despite their high cognitive ability. This is often due to difficulties with social and emotional development. ... -
Human substantia nigra and ventral tegmental area involvement in computing social error signals during the ultimatum game
(Oxford University Press, 2017-08-17)As models of shared expectations, social norms play an essential role in our societies. Since our social environment is changing constantly, our internal models of it also need to change. In humans, there is mounting ... -
Altered translation initiation of Gja1 limits gap junction formation during epithelial–mesenchymal transition
(The American Society for Cell Biology, 2018-02-13)Epithelial–mesenchymal transition (EMT) is activated during development, wound healing, and pathologies including fibrosis and cancer metastasis. Hallmarks of EMT are remodeling of intercellular junctions and adhesion ... -
Mismatch Responses in the Awake Rat: Evidence from Epidural Recordings of Auditory Cortical Fields
(PLOS, 2013-04-30)Detecting sudden environmental changes is crucial for the survival of humans and animals. In the human auditory system the mismatch negativity (MMN), a component of auditory evoked potentials (AEPs), reflects the violation ... -
Development of NMDAR Antagonists with Reduced Neurotoxic Side Effects: a Study on GK11
(PLOS, 2013-11-19)The NMDAR glutamate receptor subtype mediates various vital physiological neuronal functions. However, its excessive activation contributes to neuronal damage in a large variety of acute and chronic neurological disorders. ... -
Dynamic Causal Models and Physiological Inference: A Validation Study Using Isoflurane Anaesthesia in Rodents
(PLOS, 2011)Generative models of neuroimaging and electrophysiological data present new opportunities for accessing hidden or latent brain states. Dynamic causal modeling (DCM) uses Bayesian model inversion and selection to infer the ...
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