Fralin Biomedical Research Institute at VTC
Browse by
The Fralin Biomedical Research Institute was named in 2019, and was formerly the Virginia Tech Carilion Research Institute.
Collections in this community
-
Institute Publications, Fralin Biomedical Research Institute at VTC [0]
Newsletters, annual reports, and other Institute publications -
Scholarly Works, Fralin Biomedical Research Institute at VTC [259]
Research articles, presentations, and other scholarship
Recent Submissions
-
Attenuating Cholinergic Transmission Increases the Number of Satellite Cells and Preserves Muscle Mass in Old Age
(2019-09-24)In addition to driving contraction of skeletal muscles, acetylcholine (ACh) acts as an anti-synaptogenic agent at neuromuscular junctions (NMJs). Previous studies suggest that aging is accompanied by increases in cholinergic ... -
Access to Autism Spectrum Disorder Services for Rural Appalachian Citizens
(2020-01)Background: Low-resource rural communities face significant challenges regarding availability and adequacy of evidence-based services. Purposes: With respect to accessing evidence-based services for Autism Spectrum ... -
Selective Histone Deacetylase 6 Inhibition Normalizes B Cell Activation and Germinal Center Formation in a Model of Systemic Lupus Erythematosus
(2019-10-25)Autoantibody production by plasma cells (PCs) plays a pivotal role in the pathogenesis of systemic lupus erythematosus (SLE). The molecular pathways by which B cells become pathogenic PC secreting autoantibodies in SLE are ... -
Case study on the use of intensive pediatric neurorehabilitation in the treatment of kernicterus
(2020-02-03)Background Kernicterus Spectrum Disorder (KSD) is the result of prolonged bilirubin toxicity resulting in widespread neurological injury. Once the bilirubin levels are normalized the encephalopathy becomes static, however ... -
Longitudinal link between trait motivation and risk-taking behaviors via neural risk processing
(2019-12)Prior research has emphasized the importance of the motivational system in risky decision-making, yet the mechanisms through which individual differences in motivation may influence adolescents' risk-taking behaviors remain ... -
Women Physicians: Gender and the Medical Workplace
(Mary Ann Liebert, 2020-01-20)Understanding the work habits, attitudes, and experiences of women physicians is critical for optimal patient care. An analysis of the medical literature (1990–2017) was undertaken to answer the following question: how are ... -
Emerging Insights into the Metabolic Alterations in Aging Using Metabolomics
(MDPI, 2019-12-13)Metabolomics is the latest ‘omics’ technology and systems biology science that allows for comprehensive profiling of small-molecule metabolites in biological systems at a specific time and condition. Metabolites ... -
IL-12 signaling drives the differentiation and function of a T(H)1-derived T-FH1-like cell population
(Springer Nature, 2019-09-30)CD4(+) T follicular helper (T-FH) cells provide help to B cells and promote antibody-mediated immune responses. Increasing evidence supports the existence of T-FH populations that secrete cytokines typically associated ... -
Delayed reward discounting and grit in men and women with and without obesity
(Wiley, 2015-08-15)Objective The objective of this study was to examine how sensitivity to short-term reward and longterm goal perseverance are related to body mass index (BMI; kgm²) in a large sample of men and women with and without ... -
Alternative Splicing of RAD6B and Not RAD6A is Selectively Increased in Melanoma: Identification and Functional Characterization
(MDPI, 2019-11-01)Rad6B, a principal component of the translesion synthesis pathway, and activator of canonical Wnt signaling, plays an essential role in cutaneous melanoma development and progression. As Rad6 is encoded by two genes, namely, ... -
Auditory grouping mechanisms reflect a sound's relative position in a sequence
(Frontiers, 2012-06-08)The human brain uses acoustic cues to decompose complex auditory scenes into its components. For instance to improve communication, a listener can select an individual "stream," such as a talker in a crowded room, based ... -
Neural computations underlying social risk sensitivity
(Frontiers, 2012-08-02)Under standard models of expected utility, preferences over stochastic events are assumed to be independent of the source of uncertainty. Thus, in decision-making, an agent should exhibit consistent preferences, regardless ... -
TNF alpha Modulates Cardiac Conduction by Altering Electrical Coupling between Myocytes
(Frontiers, 2017-05-23)Background: Tumor Necrosis Factor alpha (TNF alpha) upregulation during acute inflammatory response has been associated with numerous cardiac effects including modulating Connexin43 and vascular permeability. This may in ... -
Intercalated Disk Extracellular Nanodomain Expansion in Patients With Atrial Fibrillation
(Frontiers, 2018-05-04)Aims: Atrial fibrillation (AF) is the most common sustained arrhythmia. Previous evidence in animal models suggests that the gap junction (GJ) adjacent nanodomain - perinexus - is a site capable of independent intercellular ... -
Almost Everything We Need to Better Serve Children of the Opioid Crisis We Learned in the 80s and 90s
(Frontiers, 2018-10-16)Opioid use disorder impedes dependent parents' abilities to care for their children. In turn, children may languish in unpredictability and persistent chaos. Societal responses to these children are often guided by a belief ... -
The adhesion function of the sodium channel beta subunit (beta 1) contributes to cardiac action potential propagation
(2018-08-14)Computational modeling indicates that cardiac conduction may involve ephaptic coupling - intercellular communication involving electrochemical signaling across narrow extracellular clefts between cardiomyocytes. We ... -
Acetylcholine Receptor Activation as a Modulator of Glioblastoma Invasion
(MDPI, 2019-10-05)Grade IV astrocytomas, or glioblastomas (GBMs), are the most common malignant primary brain tumor in adults. The median GBM patient survival of 12–15 months has remained stagnant, in spite of treatment strategies, ... -
Modulation of gap junction-associated Cx43 in neural stem/progenitor cells following traumatic brain injury
(2017-09)Restoration of learning and memory deficits following traumatic brain injury (TBI) is attributed, in part, to enhanced neural stem/progenitor cell (NSPCs) function. Recent findings suggest gap junction (GJ)-associated ... -
High-frequency irreversible electroporation is an effective tumor ablation strategy that induces immunologic cell death and promotes systemic anti-tumor immunity
(2019-06)Background: Despite promising treatments for breast cancer, mortality rates remain high and treatments for metastatic disease are limited. High-frequency irreversible electroporation (H-FIRE) is a novel tumor ablation ... -
EGR1 recruits TET1 to shape the brain methylome during development and upon neuronal activity
(2019-08-29)Life experience can leave lasting marks, such as epigenetic changes, in the brain. How life experience is translated into storable epigenetic information remains largely unknown. With unbiased data-driven approaches, we ...
RSS 1.0