Fralin Biomedical Research Institute at VTC
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The Fralin Biomedical Research Institute was named in 2019, and was formerly the Virginia Tech Carilion Research Institute.
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Scholarly Works, Fralin Biomedical Research Institute at VTC [269]
Research articles, presentations, and other scholarship
Recent Submissions
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Dietary and Biological Assessment of the Omega-3 Status of Collegiate Athletes: A Cross-Sectional Analysis
(PLOS, 2020-04-29)Omega-3 fatty acids (ω-3 FA) are associated with cardiovascular health, brain function, reduction of inflammation, and several other physiological roles of importance to competitive athletes. The ω-3 FA status of National ... -
Specific labeling of synaptic schwann cells reveals unique cellular and molecular features
(2020-06-25)Perisynaptic Schwann cells (PSCs) are specialized, non-myelinating, synaptic glia of the neuromuscular junction (NMJ), that participate in synapse development, function, maintenance, and repair. The study of PSCs has relied ... -
Tobacco Dependence Treatment in Oncology: Initial Patient Clinical Characteristics and Outcomes from Roswell Park Comprehensive Cancer Center
(MDPI, 2020-05-31)Despite the importance of smoking cessation to cancer care treatment, historically, few cancer centers have provided treatment for tobacco dependence. To address this gap, the National Cancer Institute (NCI) launched the ... -
Diverse GABAergic neurons organize into subtype-specific sublaminae in the ventral lateral geniculate nucleus
(Wiley, 2020-05-19)In the visual system, retinal axons convey visual information from the outside world to dozens of distinct retinorecipient brain regions and organize that information at several levels, including either at the level of ... -
The Rametrix (TM) PRO Toolbox v1.0 for MATLAB (R)
(2020-01-06)Background. Existing tools for chemometric analysis of vibrational spectroscopy data have enabled characterization of materials and biologicals by their broad molecular composition. The Rametrix (TM) LITE Toolbox v1.0 for ... -
Structural Neural Connectivity Analysis in Zebrafish With Restricted Anterograde Transneuronal Viral Labeling and Quantitative Brain Mapping
(2020-01-23)The unique combination of small size, translucency, and powerful genetic tools makes larval zebrafish a uniquely useful vertebrate system to investigate normal and pathological brain structure and function. While functional ... -
Persistent Feeding and Swallowing Deficits in a Mouse Model of 22q11.2 Deletion Syndrome
(2020-01-31)Disrupted development of oropharyngeal structures as well as cranial nerve and brainstem circuits may lead to feeding and swallowing difficulties in children with 22q11. 2 deletion syndrome (22q11DS). We previously ... -
Non-Cell Autonomous Roles for CASK in Optic Nerve Hypoplasia
(ARVO, 2019)PURPOSE. Heterozygous mutations in the essential X-linked gene CASK associate with optic nerve hypoplasia (ONH) and other retinal disorders in girls. CASKþ/ heterozygous knockout mice with mosaic CASK expression exhibit ... -
Translating Translation to Mechanisms of Cardiac Hypertrophy
(MDPI, 2020-03-10)Cardiac hypertrophy in response to chronic pathological stress is a common feature occurring with many forms of heart disease. This pathological hypertrophic growth increases the risk for arrhythmias and subsequent heart ... -
Hippocampal Subregions Express Distinct Dendritic Transcriptomes that Reveal Differences in Mitochondrial Function in CA2
(CellPress, 2019-10-08)RNA localization is one mechanism neurons use to spatially and temporally regulate gene expression at synapses. Here, we test the hypothesis that cells exhibiting distinct forms of synaptic plasticity will have differences ... -
Attenuating Cholinergic Transmission Increases the Number of Satellite Cells and Preserves Muscle Mass in Old Age
(2019-09-24)In addition to driving contraction of skeletal muscles, acetylcholine (ACh) acts as an anti-synaptogenic agent at neuromuscular junctions (NMJs). Previous studies suggest that aging is accompanied by increases in cholinergic ... -
Access to Autism Spectrum Disorder Services for Rural Appalachian Citizens
(2020-01)Background: Low-resource rural communities face significant challenges regarding availability and adequacy of evidence-based services. Purposes: With respect to accessing evidence-based services for Autism Spectrum ... -
Selective Histone Deacetylase 6 Inhibition Normalizes B Cell Activation and Germinal Center Formation in a Model of Systemic Lupus Erythematosus
(2019-10-25)Autoantibody production by plasma cells (PCs) plays a pivotal role in the pathogenesis of systemic lupus erythematosus (SLE). The molecular pathways by which B cells become pathogenic PC secreting autoantibodies in SLE are ... -
Case study on the use of intensive pediatric neurorehabilitation in the treatment of kernicterus
(2020-02-03)Background Kernicterus Spectrum Disorder (KSD) is the result of prolonged bilirubin toxicity resulting in widespread neurological injury. Once the bilirubin levels are normalized the encephalopathy becomes static, however ... -
Longitudinal link between trait motivation and risk-taking behaviors via neural risk processing
(2019-12)Prior research has emphasized the importance of the motivational system in risky decision-making, yet the mechanisms through which individual differences in motivation may influence adolescents' risk-taking behaviors remain ... -
Women Physicians: Gender and the Medical Workplace
(Mary Ann Liebert, 2020-01-20)Understanding the work habits, attitudes, and experiences of women physicians is critical for optimal patient care. An analysis of the medical literature (1990–2017) was undertaken to answer the following question: how are ... -
Potassium and glutamate transport is impaired in scar-forming tumor-associated astrocytes
(Elsevier, 2019-12-09)Unprovoked recurrent seizures are a serious comorbidity affecting most patients who suffer from glioma, a primary brain tumor composed of malignant glial cells. Cellular mechanisms contributing to the development of recurrent ... -
Emerging Insights into the Metabolic Alterations in Aging Using Metabolomics
(MDPI, 2019-12-13)Metabolomics is the latest ‘omics’ technology and systems biology science that allows for comprehensive profiling of small-molecule metabolites in biological systems at a specific time and condition. Metabolites ... -
IL-12 signaling drives the differentiation and function of a T(H)1-derived T-FH1-like cell population
(Springer Nature, 2019-09-30)CD4(+) T follicular helper (T-FH) cells provide help to B cells and promote antibody-mediated immune responses. Increasing evidence supports the existence of T-FH populations that secrete cytokines typically associated ... -
Delayed reward discounting and grit in men and women with and without obesity
(Wiley, 2015-08-15)Objective The objective of this study was to examine how sensitivity to short-term reward and longterm goal perseverance are related to body mass index (BMI; kgm²) in a large sample of men and women with and without ...
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