In 2015, approximately 8,000 intersection and intersection-related fatal crashes occurred on the nation’s highway system, resulting in more than 8,400 fatalities. That death toll represented about 24% of the traffic-related deaths across the country. Combining fatalities and injuries, intersection and intersection-related crashes represent more than 50% of the traffic-related injuries across the nation. Unsignalized intersections are of particular concern. Between 2010 and 2014, unsignalized intersections were responsible for more than 70% of the intersection and intersection-related fatalities. This report documents 83 suitable safety countermeasures that can be used at unsignalized intersections to mitigate crash risks. A number of these have potential for cost-effective, systemic implementation, including LED-enhanced Stop signs, retroreflective panels on sign posts, center line pavement markings in a median crossing, center line pavement markings on the minor road approach, and installation of intersection lighting.