A virtual hair cell, II: Evaluation of mechanoelectric transduction parameters

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dc.contributorVirginia Techen
dc.contributor.authorNam, Jong-Hoonen
dc.contributor.authorCotton, John R.en
dc.contributor.authorGrant, John Wallaceen
dc.contributor.departmentBiomedical Engineering and Mechanicsen
dc.date.accessed2014-02-05en
dc.date.accessioned2014-02-26T19:10:05Zen
dc.date.available2014-02-26T19:10:05Zen
dc.date.issued2007-03-01en
dc.description.abstractThe virtual hair cell we have proposed utilizes a set of parameters related to its mechanoelectric transduction. In this work, we observed the effect of such channel gating parameters as the gating threshold, critical tension, resting tension, and Ca2+ concentration. The gating threshold is the difference between the resting and channel opening tension exerted by the tip link assembly on the channel. The critical tension is the tension in the tip link assembly over which the channel cannot close despite Ca2+ binding. Our results show that 1), the gating threshold dominated the initial sensitivity of the hair cell; 2), the critical tension minimally affects the peak response, l(t), but considerably affects the time course of response, l(t), and the force-displacement, F-X, relationship; and 3), higher intracellular [Ca2+] resulted in a smaller fast adaptation time constant. Based on the simulation results we suggest a role of the resting tension: to help overcome the viscous drag of the hair bundle during the oscillatory movement of the bundle. Also we observed the three-dimensional bundle effect on the hair cell response by varying the number of cilia forced. These varying forcing conditions affected the hair cell response.en
dc.description.sponsorshipNational Institutes of Health NIDCD R01 DC05063, NIDCD R01 DC 002290-12en
dc.format.mimetypeapplication/pdfen
dc.identifier.citationNam, Jong-Hoon; Cotton, John R.; Grant, Wally. "A virtual hair cell, II: Evaluation of mechanoelectric transduction parameters," Biophysical Journal 92(6), 1929-1937 (2007); doi: 10.1529/biophysj.106.085092en
dc.identifier.doihttps://doi.org/10.1529/biophysj.106.085092en
dc.identifier.issn0006-3495en
dc.identifier.urihttp://hdl.handle.net/10919/25776en
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0006349507710007en
dc.language.isoenen
dc.publisherCELL PRESSen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectBundle motionen
dc.subjectSpontaneous oscillationen
dc.subjectMechanical propertiesen
dc.subjectBullfrogsen
dc.subjectSacculusen
dc.subjectNegative stiffnessen
dc.subjectCiliary bundlesen
dc.subjectAdaptationen
dc.subjectChannelsen
dc.subjectStereociliaen
dc.subjectForcesen
dc.titleA virtual hair cell, II: Evaluation of mechanoelectric transduction parametersen
dc.title.serialBiophysical Journalen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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