Subsecond dopamine fluctuations in human striatum encode superposed error signals about actual and counterfactual reward

Simple item page
dc.contributorVirginia Techen
dc.contributor.authorKishida, Kenneth T.en
dc.contributor.authorSáez, Ignacioen
dc.contributor.authorLohrenz, Terryen
dc.contributor.authorWitcher, Mark R.en
dc.contributor.authorTatter, Stephen B.en
dc.contributor.authorWhite, Jason P.en
dc.contributor.authorEllis, Thomas L.en
dc.contributor.authorPhillips, Paul E. M.en
dc.contributor.authorMontague, P. Readen
dc.contributor.authorLaxton, Adrian W.en
dc.date.accessioned2017-09-08T14:18:49Zen
dc.date.available2017-09-08T14:18:49Zen
dc.date.issued2016-01-05en
dc.description.abstractIn the mammalian brain, dopamine is a critical neuromodulator whose actions underlie learning, decision-making, and behavioral control. Degeneration of dopamine neurons causes Parkinson’s disease, whereas dysregulation of dopamine signaling is believed to contribute to psychiatric conditions such as schizophrenia, addiction, and depression. Experiments in animal models suggest the hypothesis that dopamine release in human striatum encodes reward prediction errors (RPEs) (the difference between actual and expected outcomes) during ongoing decision-making. Blood oxygen level-dependent (BOLD) imaging experiments in humans support the idea that RPEs are tracked in the striatum; however, BOLD measurements cannot be used to infer the action of any one specific neurotransmitter. We monitored dopamine levels with subsecond temporal resolution in humans (n = 17) with Parkinson’s disease while they executed a sequential decision-making task. Participants placed bets and experienced monetary gains or losses. Dopamine fluctuations in the striatum fail to encode RPEs, as anticipated by a large body of work in model organisms. Instead, subsecond dopamine fluctuations encode an integration of RPEs with counterfactual prediction errors, the latter defined by how much better or worse the experienced outcome could have been. How dopamine fluctuations combine the actual and counterfactual is unknown. One possibility is that this process is the normal behavior of reward processing dopamine neurons, which previously had not been tested by experiments in animal models. Alternatively, this superposition of error terms may result from an additional yet-to-be-identified subclass of dopamine neurons.en
dc.identifier.doihttps://doi.org/10.1073/pnas.1513619112en
dc.identifier.issue1en
dc.identifier.urihttp://hdl.handle.net/10919/78830en
dc.identifier.volume113en
dc.language.isoen_USen
dc.publisherNASen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectdopamineen
dc.subjectreward prediction erroren
dc.subjectcounterfactual prediction erroren
dc.subjectdecision-makingen
dc.subjecthuman fast-scan cyclic voltammetryen
dc.titleSubsecond dopamine fluctuations in human striatum encode superposed error signals about actual and counterfactual rewarden
dc.title.serialPNASen
dc.typeArticle - Refereeden

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
MontagueSubsecondDopamine2016.pdf
Size:
880.86 KB
Format:
Adobe Portable Document Format
Description:
Download

Collections

Destination Area: Adaptive Brain and Behavior (ABB)
Scholarly Works, Fralin Biomedical Research Institute at VTC