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Nonlinear Elasto-Mammography for Characterization of Breast Tissue Properties

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dc.contributor.authorWang, Z. G.en
dc.contributor.authorLiu, Y.en
dc.contributor.authorWang, G.en
dc.contributor.authorSun, L. Z.en
dc.contributor.departmentSchool of Biomedical Engineering and Sciencesen
dc.date.accessioned2017-09-18T09:51:46Zen
dc.date.available2017-09-18T09:51:46Zen
dc.date.issued2011-12-22en
dc.date.updated2017-09-18T09:51:46Zen
dc.description.abstractQuantification of the mechanical behavior of normal and cancerous tissues has important implication in the diagnosis of breast tumor. The present work extends the authors' nonlinear elastography framework to incorporate the conventional X-ray mammography, where the projection of displacement information is acquired instead of full three-dimensional (3D) vector. The elastic parameters of normal and cancerous breast tissues are identified by minimizing the difference between the measurement and the corresponding computational prediction. An adjoint method is derived to calculate the gradient of the objective function. Simulations are conducted on a 3D breast phantom consisting of the fatty tissue, glandular tissue, and cancerous tumor, whose mechanical responses are hyperelastic in nature. The material parameters are identified with consideration of measurement error. The results demonstrate that the projective displacements acquired in X-ray mammography provide sufficient constitutive information of the tumor and prove the usability and robustness of the proposed method and algorithm.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationZ. G. Wang, Y. Liu, G. Wang, and L. Z. Sun, “Nonlinear Elasto-Mammography for Characterization of Breast Tissue Properties,” International Journal of Biomedical Imaging, vol. 2011, Article ID 540820, 10 pages, 2011. doi:10.1155/2011/540820en
dc.identifier.doihttps://doi.org/10.1155/2011/540820en
dc.identifier.urihttp://hdl.handle.net/10919/79018en
dc.language.isoenen
dc.publisherHindawien
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.holderCopyright © 2011 Z. G. Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleNonlinear Elasto-Mammography for Characterization of Breast Tissue Propertiesen
dc.title.serialInternational Journal of Biomedical Imagingen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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