Intracranial Squamous Cell Carcinoma Arising From a Cerebellopontine Angle Epidermoid Cyst Remnant Four Decades After Partial Resection

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dc.contributor.authorCuoco, Joshua A.en
dc.contributor.authorRogers, Cara M.en
dc.contributor.authorBusch, Christopher M.en
dc.contributor.authorApfel, Lisa S.en
dc.contributor.authorEntwistle, John J.en
dc.contributor.authorMarvin, Eric A.en
dc.contributor.departmentSchool of Neuroscienceen
dc.contributor.departmentVirginia Tech Carilion School of Medicineen
dc.date.accessioned2019-10-24T19:02:08Zen
dc.date.available2019-10-24T19:02:08Zen
dc.date.issued2019-07-30en
dc.description.abstractIntracranial epidermoid cysts are benign lesions that typically remain asymptomatic; however, although histopathologically benign, these cysts can rarely undergo malignant transformation into squamous cell carcinoma. Primary intracranial squamous cell carcinoma carries a poor prognosis as optimal treatment modalities remain unclear due to their low incidence. Here, we present a case of a cerebellopontine angle epidermoid cyst remnant that underwent malignant transformation into squamous cell carcinoma 40 years after partial resection. To our knowledge, this case establishes the longest time interval to date for an intracranial epidermoid cyst to undergo malignant transformation. We also review the relevant literature and discuss recent retrospective clinical studies that have analyzed the effect of multimodal treatment approaches on survival outcomes in patients with these lesions.en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3389/fonc.2019.00694en
dc.identifier.issn2234-943Xen
dc.identifier.other694en
dc.identifier.pmid31428577en
dc.identifier.urihttp://hdl.handle.net/10919/95046en
dc.identifier.volume9en
dc.language.isoenen
dc.publisherFrontiersen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectepidermoid cysten
dc.subjectsquamous cell carcinomaen
dc.subjectmalignant transformationen
dc.subjectmalignant degenerationen
dc.subjectcerebellopontine angleen
dc.subjectbrain neoplasmen
dc.subjectneuro-oncologyen
dc.titleIntracranial Squamous Cell Carcinoma Arising From a Cerebellopontine Angle Epidermoid Cyst Remnant Four Decades After Partial Resectionen
dc.title.serialFrontiers in Oncologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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