A systems approach to the evaluation of natural resource management initiatives

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dc.contributor.authorBellamy, J. A.en
dc.contributor.authorWalker, D. H.en
dc.contributor.authorMcDonald, G. T.en
dc.contributor.authorSyme, G. J.en
dc.contributor.departmentSustainable Agriculture and Natural Resource Management (SANREM) Knowledgebaseen
dc.coverage.spatialAustraliaen
dc.date.accessioned2016-04-19T18:55:39Zen
dc.date.available2016-04-19T18:55:39Zen
dc.date.issued2001en
dc.descriptionMetadata only recorden
dc.description.abstractThe data presented pertain to a research article titled “Heme Oxygenase 1 Up-Regulates Glomerular Decay Accelerating Factor Expression and Minimizes Complement Deposition and Injury” (Detsika et al., 2016). The present work provides additional data on induction and immunolocalization of heme oxygenase (HO)-1 (an antioxidant enzyme) and decay-accelerating factor (DAF) (a complement activation inhibitor) in isolated rat glomeruli and in glomerular epithelial cells (podocytes) in response to Iron Protoporphyrin IX (FePP, heme), and to non-iron protoporphyrins (PPs) with varying metal functionalities (ZnPP, SnPP), including a metal-devoid PP. Induction and immuno-localization of HO-1 and DAF in response to these metalloporphyrins (MP) were assessed using western blot analyses and confocal microscopy in isolated glomeruli and in cultured podocytes. These analyses identified podocytes as a major localization site of HO-1 and DAF induction in response to the aforementioned MPs. Effects of these MPs on a key glomerular structural protein, Nephrin, are also reported. The data identify MPs most and least capable of inducing DAF and reducing Nephrin expression and provide clues into expected outcomes of animal studies assessing MP efficacy in upregulating the cytoprotective proteins HO-1 and DAF.en
dc.format.mimetypetext/plainen
dc.identifier1069en
dc.identifier.citationJournal of Environmental Management 63(4): 407-423en
dc.identifier.issn0301-4797en
dc.identifier.urihttp://hdl.handle.net/10919/65925en
dc.language.isoen_USen
dc.publisherAcademic Pressen
dc.rightsIn Copyrighten
dc.rights.holderCopyright 2001 Academic Pressen
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectNatural resource managementen
dc.subjectSystems approachen
dc.subjectEnvironmental policyen
dc.subjectCommunity-based management policyen
dc.subjectEcosystem Governanceen
dc.titleA systems approach to the evaluation of natural resource management initiativesen
dc.typeAbstracten
dc.type.dcmitypeTexten

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