Water soluble derivatives of taxol
| dc.contributor.assignee | Virginia Tech Intellectual Properties, Inc. | en |
| dc.contributor.inventor | Kingston, David G. I. | en |
| dc.contributor.inventor | Zhao, Zhi-Yang | en |
| dc.date.accessed | 2016-08-19 | en |
| dc.date.accessioned | 2016-08-24T17:55:36Z | en |
| dc.date.available | 2016-08-24T17:55:36Z | en |
| dc.date.filed | 1991-10-15 | en |
| dc.date.issued | 1994-01-11 | en |
| dc.description.abstract | Sulfonated 2'-acryloyltaxol and sulfonated 2'-O-acyl acid taxol derivatives are synthesized which have improved water solubility and stability while maintaining bioactivity. In particular, 2'-[(3-sulfo-1-oxopropyl)oxy]taxol sodium salt is synthesized by reacting taxol with acrylic acid, and subsequently reacting the 2'-acryloyltaxol with bisulfite in a Michael reaction. 2'-{[4-((2-sulfoethyl)amino)-1,4-dioxobutyl]oxy}taxol sodium salt and 2'-{[4-((3-sulfopropyl)amino)-1,4-dioxobutyl]oxy}taxol sodium salt are synthesized by reacting 2'-succinyltaxol with the tetrabutylammonium salts of taurine and 3-aminopropyl sulfonic acid, respectively, and subsequently exchanging the ammonium with sodium. Glycol derivatives of 2'-O-acyl acid taxols with improved water solubility are synthesized by reaction of a glycol with 2'-O-acyl acid taxol. | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.applicationnumber | 7774107 | en |
| dc.identifier.patentnumber | 5278324 | en |
| dc.identifier.uri | http://hdl.handle.net/10919/72807 | en |
| dc.identifier.url | http://pimg-fpiw.uspto.gov/fdd/24/783/052/0.pdf | en |
| dc.language.iso | en_US | en |
| dc.publisher | United States Patent and Trademark Office | en |
| dc.subject.cpc | C07D305/14 | en |
| dc.subject.uspc | 549/510 | en |
| dc.subject.uspcother | 549/511 | en |
| dc.title | Water soluble derivatives of taxol | en |
| dc.type | Patent | en |
| dc.type.dcmitype | Text | en |
| dc.type.patenttype | utility | en |
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