Sensitivity Analysis of an Individual-Based Model for Simulation of Influenza Epidemics

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dc.contributorVirginia Techen
dc.contributor.authorNsoesie, Elaine O.en
dc.contributor.authorBeckman, Richard J.en
dc.contributor.authorMarathe, Madhav V.en
dc.date.accessed2014-05-06en
dc.date.accessioned2014-06-17T20:12:08Zen
dc.date.available2014-06-17T20:12:08Zen
dc.date.issued2012-10-29en
dc.description.abstractIndividual-based epidemiology models are increasingly used in the study of influenza epidemics. Several studies on influenza dynamics and evaluation of intervention measures have used the same incubation and infectious period distribution parameters based on the natural history of influenza. A sensitivity analysis evaluating the influence of slight changes to these parameters (in addition to the transmissibility) would be useful for future studies and real-time modeling during an influenza pandemic. In this study, we examined individual and joint effects of parameters and ranked parameters based on their influence on the dynamics of simulated epidemics. We also compared the sensitivity of the model across synthetic social networks for Montgomery County in Virginia and New York City (and surrounding metropolitan regions) with demographic and rural-urban differences. In addition, we studied the effects of changing the mean infectious period on age-specific epidemics. The research was performed from a public health standpoint using three relevant measures: time to peak, peak infected proportion and total attack rate. We also used statistical methods in the design and analysis of the experiments. The results showed that: (i) minute changes in the transmissibility and mean infectious period significantly influenced the attack rate; (ii) the mean of the incubation period distribution appeared to be sufficient for determining its effects on the dynamics of epidemics; (iii) the infectious period distribution had the strongest influence on the structure of the epidemic curves; (iv) the sensitivity of the individual-based model was consistent across social networks investigated in this study and (v) age-specific epidemics were sensitive to changes in the mean infectious period irrespective of the susceptibility of the other age groups. These findings suggest that small changes in some of the disease model parameters can significantly influence the uncertainty observed in real-time forecasting and predicting of the characteristics of an epidemic.en
dc.description.sponsorshipThis work has been partially supported by National Science Foundation Netse Grant CNS-1011769, Defense Threat Reduction Agency (DTRA) R&D Grant HDTRA1-0901-0017, DTRA Comprehensive National Incident Management System (CNIMS) Grant HDTRA1-07-C-0113, National Institutes of Health Models of Infectious Disease Study (MIDAS) project 2U01GM070694-7 and DTRA Rigorous Approaches for Validation and Verification of Networked Systems Grant. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en
dc.identifier.citationNsoesie E, Beckman R, and Marathe M. Sensitivity Analysis of an Individual-Based Model for Simulation of Influenza Epidemics. PLOS ONE. 2012; 7(10), e45414.en
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0045414en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://hdl.handle.net/10919/48998en
dc.identifier.urlhttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0045414en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectAge groupsen
dc.subjectChildrenen
dc.subjectDistribution curvesen
dc.subjectInfectious disease epidemiologyen
dc.subjectInfluenzaen
dc.subjectPopulation groupingsen
dc.subjectProbability distributionen
dc.subjectSocial networksen
dc.titleSensitivity Analysis of an Individual-Based Model for Simulation of Influenza Epidemicsen
dc.title.serialPLoS ONEen
dc.typeArticle - Refereeden

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