A Case of Childhood Severe Paroxysmal Cold Hemoglobinuria with Acute Renal Failure Successfully Treated with Plasma Exchange and Eculizumab
| dc.contributor.author | Pelletier, Jessica | en |
| dc.contributor.author | Ward, Chad | en |
| dc.contributor.author | Borloz, Matthew | en |
| dc.contributor.author | Ickes, Anne | en |
| dc.contributor.author | Guelich, Susan | en |
| dc.contributor.author | Edwards, Erwood | en |
| dc.date.accessioned | 2022-04-25T13:13:41Z | en |
| dc.date.available | 2022-04-25T13:13:41Z | en |
| dc.date.issued | 2022-04-22 | en |
| dc.date.updated | 2022-04-24T08:00:08Z | en |
| dc.description.abstract | We describe the case of a 4-year-old female who presented with sepsis and disseminated intravascular coagulation (DIC), developed ongoing intravascular hemolysis with acute renal failure from suspected pigment-induced acute tubular necrosis necessitating continuous renal replacement therapy (CRRT) for five days followed by four episodes of intermittent hemodialysis (iHD), and was subsequently diagnosed with paroxysmal cold hemoglobinuria (PCH). She was successfully treated with plasma exchange and eculizumab, a humanized monoclonal antibody targeting complement protein C5, and demonstrated significant improvement of hemolysis and recovery of renal function. | en |
| dc.description.version | Published version | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.citation | Jessica Pelletier, Chad Ward, Matthew Borloz, Anne Ickes, Susan Guelich, and Erwood Edwards, Jr., “A Case of Childhood Severe Paroxysmal Cold Hemoglobinuria with Acute Renal Failure Successfully Treated with Plasma Exchange and Eculizumab,” Case Reports in Pediatrics, vol. 2022, Article ID 3267189, 5 pages, 2022. doi:10.1155/2022/3267189 | en |
| dc.identifier.doi | https://doi.org/10.1155/2022/3267189 | en |
| dc.identifier.uri | http://hdl.handle.net/10919/109741 | en |
| dc.language.iso | en | en |
| dc.publisher | Hindawi | en |
| dc.rights | Creative Commons Attribution 4.0 International | en |
| dc.rights.holder | Copyright © 2022 Jessica Pelletier et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | en |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en |
| dc.title | A Case of Childhood Severe Paroxysmal Cold Hemoglobinuria with Acute Renal Failure Successfully Treated with Plasma Exchange and Eculizumab | en |
| dc.title.serial | Case Reports in Pediatrics | en |
| dc.type | Article - Refereed | en |
| dc.type.dcmitype | Text | en |