Supramolecular metallic complexes exhibiting both DNA binding and photocleavage

Supramolecular metallic complexes exhibiting both DNA binding and photocleavage

dc.contributor.assignee	Virginia Tech Intellectual Properties, Inc.	en
dc.contributor.inventor	Brewer, Karen J.	en
dc.contributor.inventor	Winkel, Brenda S. J.	en
dc.date.accessed	2016-08-19	en
dc.date.accessioned	2016-08-24T17:55:07Z	en
dc.date.available	2016-08-24T17:55:07Z	en
dc.date.filed	2007-09-07	en
dc.date.issued	2012-04-03	en
dc.description.abstract	Supramolecular complexes that target and cleave DNA are provided. The supramolecular complexes include at least one metal-to-ligand charge transfer (MLCT) light absorbing unit, at least one Pt based DNA binding unit, and at least one bridging unit that serves to connect the components. The Pt-based DNA binding unit binds the complex to DNA, and the MLCT unit absorbs light, thereby sensitizing molecular oxygen to produce reactive oxygen species in close proximity to the complex and the bound DNA. The reactive oxygen species cleave the bound DNA.	en
dc.format.mimetype	application/pdf	en
dc.identifier.applicationnumber	11851689	en
dc.identifier.patentnumber	8148360	en
dc.identifier.uri	http://hdl.handle.net/10919/72677	en
dc.identifier.url	http://pimg-fpiw.uspto.gov/fdd/60/483/081/0.pdf	en
dc.language.iso	en_US	en
dc.publisher	United States Patent and Trademark Office	en
dc.subject.cpc	A61K31/555	en
dc.subject.cpc	A61K41/0042	en
dc.subject.cpc	A61K41/0057	en
dc.subject.cpc	A61K47/48153	en
dc.subject.uspc	514/186	en
dc.subject.uspcother	514/185	en
dc.subject.uspcother	514/188	en
dc.subject.uspcother	544/225	en
dc.title	Supramolecular metallic complexes exhibiting both DNA binding and photocleavage	en
dc.type	Patent	en
dc.type.dcmitype	Text	en
dc.type.patenttype	utility	en

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