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Louse- and flea-borne rickettsioses: biological and genomic analyses

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dc.contributor.authorGillespie, Joseph J.en
dc.contributor.authorAmmerman, Nicole C.en
dc.contributor.authorBeier-Sexton, Magdaen
dc.contributor.authorSobral, Brunoen
dc.contributor.authorAzad, Abdu F.en
dc.date.accessed2014-05-08en
dc.date.accessioned2014-05-14T17:03:35Zen
dc.date.available2014-05-14T17:03:35Zen
dc.date.issued2009-03en
dc.description.abstractIn contrast to 15 or more validated and/or proposed tick-borne spotted fever group species, only three named medically important rickettsial species are associated with insects. These insect-borne rickettsiae are comprised of two highly pathogenic species, Rickettsia prowazekii (the agent of epidemic typhus) and R. typhi (the agent of murine typhus), as well as R. felis, a species with unconfirmed pathogenicity. Rickettsial association with obligate hematophagous insects such as the human body louse (R. prowazekii transmitted by Pediculus h. humanus) and several flea species (R. typhi and R. felis, as well as R. prowazekii in sylvatic form) provides rickettsiae the potential for further multiplications, longer transmission cycles and rapid spread among susceptible human populations. Both human body lice and fleas are intermittent feeders capable of multiple blood meals per generation, facilitating the efficient transmission of rickettsiae to several disparate hosts within urban/rural ecosystems. While taking into consideration the existing knowledge of rickettsial biology and genomic attributes, we have analyzed and summarized the interacting features that are unique to both the rickettsiae and their vector fleas and lice. Furthermore, factors that underlie rickettsial changing ecology, where native mammalian populations are involved in the maintenance of rickettsial cycle and transmission, are discussed.en
dc.description.sponsorshipNational Institute of Allergy and Infectious Diseases (NIAID) R01AI017828 , R01AI59118en
dc.description.sponsorshipNIAID HHSN266200400035Cen
dc.identifier.citationJoseph J. Gillespie; Nicole C. Ammerman; Magda Beier-Sexton; Bruno S. Sobral; Abdu F. Azad., "Louse- and flea-borne rickettsioses: biological and genomic analyses," Vet. Res. (2009) 40:12 DOI: 10.1051/vetres:2008050en
dc.identifier.doihttps://doi.org/10.1051/vetres:2008050en
dc.identifier.issn0928-4249en
dc.identifier.urihttp://hdl.handle.net/10919/48025en
dc.identifier.urlhttp://www.vetres.org/articles/vetres/abs/2009/02/v08288/v08288.htmlen
dc.language.isoen_USen
dc.publisherEDP SCIENCESen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectepidemic and murine typhusen
dc.subjectecologyen
dc.subjectrickettsial biologyen
dc.subjectrecrudescenten
dc.subjecttyphusen
dc.subjectcolonized cat fleasen
dc.subjectmurine typhusen
dc.subjectctenocephalides-felisen
dc.subjectepidemicen
dc.subjecttyphusen
dc.subjectspotted-feveren
dc.subjectmolecular-identificationen
dc.subjectflying squirrelsen
dc.subjectarp2/3 complexen
dc.subjectunited-statesen
dc.subjectcell-lineen
dc.subjectveterinary sciencesen
dc.titleLouse- and flea-borne rickettsioses: biological and genomic analysesen
dc.title.serialVeterinary Researchen
dc.typeReviewen

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