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Monocyte Count on Admission Is Predictive of Shunt-Dependent Hydrocephalus After Aneurysmal Subarachnoid Hemorrhage

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dc.contributor.authorCuoco, Joshua A.en
dc.contributor.authorGuilliams, Evin L.en
dc.contributor.authorKlein, Brendan J.en
dc.contributor.authorWitcher, Mark R.en
dc.contributor.authorMarvin, Eric A.en
dc.contributor.authorPatel, Biraj M.en
dc.contributor.authorEntwistle, John J.en
dc.date.accessioned2022-06-29T18:15:05Zen
dc.date.available2022-06-29T18:15:05Zen
dc.date.issued2022-04-28en
dc.description.abstractThe authors sought to evaluate whether immunologic counts on admission were associated with shunt-dependent hydrocephalus following aneurysmal subarachnoid hemorrhage. A retrospective analysis of 143 consecutive patients with aneurysmal subarachnoid hemorrhage over a 9-year period was performed. A stepwise algorithm was followed for external ventricular drain weaning and determining the necessity of shunt placement. Data were compared between patients with and without shunt-dependent hydrocephalus. Overall, 11.19% of the cohort developed shunt-dependent hydrocephalus. On multivariate logistic regression analysis, acute hydrocephalus (OR: 61.027, 95% CI: 3.890-957.327; p = 0.003) and monocyte count on admission (OR: 3.362, 95% CI: 1.024-11.037; p = 0.046) were found to be independent predictors for shunt dependence. Receiver operating characteristic curve analysis for the prediction of shunt-dependent hydrocephalus confirmed that monocyte count exhibited an acceptable area under the curve (AUC = 0.737, 95% CI: 0.601-0.872; p < 0.001). The best predictive cutoff value to discriminate between successful external ventricular drain weaning and shunt-dependent hydrocephalus was identified as a monocyte count >= 0.80 x 10(3)/uL at initial presentation. These preliminary data demonstrate that a monocyte count >= 0.80 x 10(3)/uL at admission predicts shunt-dependent hydrocephalus in patients with aneurysmal subarachnoid hemorrhage; however, further large-scale prospective trials and validation are necessary to confirm these findings.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3389/fsurg.2022.879050en
dc.identifier.issn2296-875Xen
dc.identifier.other879050en
dc.identifier.pmid35574528en
dc.identifier.urihttp://hdl.handle.net/10919/110978en
dc.identifier.volume9en
dc.language.isoenen
dc.publisherFrontiersen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectaneurysmal subarachnoid hemorrhageen
dc.subjectimmune systemen
dc.subjecthydrocephalusen
dc.subjectmonocyteen
dc.subjectshunt-dependenceen
dc.titleMonocyte Count on Admission Is Predictive of Shunt-Dependent Hydrocephalus After Aneurysmal Subarachnoid Hemorrhageen
dc.title.serialFrontiers in Surgeryen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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