Clinical, Morphological, and Molecular Characterization of Penicillium canis sp nov., Isolated from a Dog with Osteomyelitis

dc.contributor.authorLanglois, Daniel K.en
dc.contributor.authorSutton, Deanna A.en
dc.contributor.authorSwenson, Cheryl L.en
dc.contributor.authorBailey, Chris J.en
dc.contributor.authorWiederhold, Nathan P.en
dc.contributor.authorNelson, Nathan C.en
dc.contributor.authorThompson, Elizabeth H.en
dc.contributor.authorWickes, Brian L.en
dc.contributor.authorFrench, Stephanieen
dc.contributor.authorFu, Jianminen
dc.contributor.authorVilar-Saavedra, Pauloen
dc.contributor.authorPeterson, Stephen W.en
dc.contributor.departmentVirginia-Maryland Regional College of Veterinary Medicine. Department of Small Animal Clinical Sciencesen
dc.contributor.editorWarnock, D. W.en
dc.date.accessed2015-11-28en
dc.date.accessioned2015-11-29T04:13:28Zen
dc.date.available2015-11-29T04:13:28Zen
dc.date.issued2014-04-17en
dc.description.abstractInfections caused by Penicillium species are rare in dogs, and the prognosis in these cases is poor. An unknown species of Penicillium was isolated from a bone lesion in a young dog with osteomyelitis of the right ilium. Extensive diagnostic evaluation did not reveal evidence of dissemination. Resolution of lameness and clinical stability of disease were achieved with intravenous phospholipid- complexed amphotericin B initially, followed by long-term combination therapy with terbinafine and ketoconazole. A detailed morphological and molecular characterization of the mold was undertaken. Sequence analysis of the internal transcribed spacer revealed the isolate to be closely related to Penicillium menonorum and Penicillium pimiteouiense. Additional sequence analysis of beta-tubulin, calmodulin, minichromosome maintenance factor, DNA-dependent RNA polymerase, and pre-rRNA processing protein revealed the isolate to be a novel species; the name Penicillium canis sp. nov. is proposed. Morphologically, smooth, ovoid conidia, a greenish gray colony color, slow growth on all media, and a failure to form ascomata distinguish this species from closely related Penicillium species.en
dc.description.sponsorshipMichigan State University. College of Veterinary Medicine Trinket Funden
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationLanglois, Daniel K. et al. (2014). Clinical, Morphological, and Molecular Characterization of Penicillium canis sp nov., Isolated from a Dog with Osteomyelitis. Journal of Clinical Microbiology, 52(7), 2447-2453. doi:10.1128/jcm.03602-13en
dc.identifier.doihttps://doi.org/10.1128/jcm.03602-13en
dc.identifier.issn0095-1137en
dc.identifier.urihttp://hdl.handle.net/10919/64227en
dc.identifier.urlhttp://jcm.asm.org/content/52/7/2447en
dc.language.isoenen
dc.publisherAmerican Society for Microbiologyen
dc.rightsIn Copyrighten
dc.rights.holderAmerican Society for Microbiologyen
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.titleClinical, Morphological, and Molecular Characterization of Penicillium canis sp nov., Isolated from a Dog with Osteomyelitisen
dc.title.serialJournal of Clinical Microbiologyen
dc.typeArticle - Refereeden
dc.typeDataseten
dc.type.dcmitypeTexten
dc.type.dcmitypeDataseten
Files
Original bundle
Now showing 1 - 2 of 2
Loading...
Thumbnail Image
Name:
J. Clin. Microbiol.-2014-Langlois-2447-53.pdf
Size:
1.97 MB
Format:
Adobe Portable Document Format
Description:
Loading...
Thumbnail Image
Name:
zjm007143537so1.pdf
Size:
91.61 KB
Format:
Adobe Portable Document Format
Description: