Anticancer nanoparticulate polymer-drug conjugate

dc.contributor.authorFeng, Quanyouen
dc.contributor.authorTong, Rongen
dc.date.accessioned2020-11-09T17:07:42Zen
dc.date.available2020-11-09T17:07:42Zen
dc.date.issued2016-08-26en
dc.description.abstractWe review recent progress in polymer-drug conjugate for cancer nanomedicine. Polymer-drug conjugates, including the nanoparticle prepared from these conjugates, are designed to release drug in tumor tissues or cells in order to improve drugs’ therapeutic efficacy. We summarize general design principles for the polymer-drug conjugate, including the synthetic strategies, the design of the chemical linkers between the drug and polymer in the conjugate, and the in vivo drug delivery barriers for polymer-drug conjugates. Several new strategies, such as the synthesis of polymerdrug conjugates and supramolecular-drug conjugates, the use of stimulus-responsive delivery, and triggering the change of the nanoparticle physiochemical properties to over delivery barriers, are also highlighted.en
dc.identifier.doihttps://doi.org/10.1002/btm2.10033en
dc.identifier.urihttp://hdl.handle.net/10919/100809en
dc.identifier.volume1en
dc.language.isoen_USen
dc.publisherWileyen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectdrug deliveryen
dc.subjectnanomedicineen
dc.subjectnanoparticleen
dc.subjectpolymer-drug conjugateen
dc.subjectstimuli-responsiveen
dc.titleAnticancer nanoparticulate polymer-drug conjugateen
dc.title.serialBioengineering & Translational Medicineen
dc.typeArticle - Refereeden
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