Globally Optimized Parameters for a Model of Mitotic Control in Frog Egg Extracts

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dc.contributor.authorZwolak, Jason W.en
dc.contributor.authorTyson, John J.en
dc.contributor.authorWatson, Layne T.en
dc.contributor.departmentComputer Scienceen
dc.date.accessioned2013-06-19T14:36:46Zen
dc.date.available2013-06-19T14:36:46Zen
dc.date.issued2004en
dc.description.abstractDNA synthesis and nuclear division in the developing frog egg are controlled by fluctuations in the activity of M-phase promoting factor (MPF). The biochemical mechanism of MPF regulation is most easily studied in cytoplasmic extracts of frog eggs, for which careful experimental studies of the kinetics of phosphorylation and dephosphorylation of MPF and its regulators have been made. In 1998 Marlovits et al. used these data sets to estimate the kinetic rate constants in a mathematical model of the control system originally proposed by Novak and Tyson. In a recent publication, we showed that a gradient-based optimization algorithm finds a locally optimal parameter set quite close to the Marlovits estimates. In this paper, we combine global and local optimization strategies to show that the refined Marlovits parameter set, with one minor but significant modification to the Novak-Tyson equations, is the unique, best-fitting solution to the parameter estimation problem.en
dc.format.mimetypeapplication/pdfen
dc.identifierhttp://eprints.cs.vt.edu/archive/00000695/en
dc.identifier.sourceurlhttp://eprints.cs.vt.edu/archive/00000695/01/6.pdfen
dc.identifier.trnumberTR-04-18en
dc.identifier.urihttp://hdl.handle.net/10919/20181en
dc.language.isoenen
dc.publisherDepartment of Computer Science, Virginia Polytechnic Institute & State Universityen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectAlgorithmsen
dc.subjectData structuresen
dc.titleGlobally Optimized Parameters for a Model of Mitotic Control in Frog Egg Extractsen
dc.typeTechnical reporten
dc.type.dcmitypeTexten

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