Detection, isolation and purification of Clostridium difficile toxin A with toxin receptors

dc.contributor.assigneeVirginia Tech Intellectual Properties, Inc.en
dc.contributor.inventorWilkins, Tracy D.en
dc.contributor.inventorTucker, Kenneth D.en
dc.date.accessed2016-08-19en
dc.date.accessioned2016-08-24T17:54:51Zen
dc.date.available2016-08-24T17:54:51Zen
dc.date.filed1990-03-09en
dc.date.issued1992-03-24en
dc.description.abstractA method is provided for detecting the presence of C. difficile toxin A. Stool or other appropriate specimen is contacted with a reagent containing the human X, Y or I-antigens, each of which is a specific receptor for toxin A. The reagent may be intact cells, cell membranes, membrane fractions containing any of these antigens, glycoconjugates, as well as the purified oligosaccharide antigen per se. Binding of toxin A is determined by conventional assay techniques. The method may also be used to isolate and purify toxin A. Conversely, immobilized toxin A may be used to detect, isolate, or purify biological materials of interest expressing the X, Y or I antigens.en
dc.format.mimetypeapplication/pdfen
dc.identifier.applicationnumber7491396en
dc.identifier.patentnumber5098826en
dc.identifier.urihttp://hdl.handle.net/10919/72607en
dc.identifier.urlhttp://pimg-fpiw.uspto.gov/fdd/26/988/050/0.pdfen
dc.language.isoen_USen
dc.publisherUnited States Patent and Trademark Officeen
dc.subject.cpcC07K14/33en
dc.subject.cpcC12P19/26en
dc.subject.cpcG01N33/56911en
dc.subject.uspc435/7.32en
dc.subject.uspcother530/350en
dc.titleDetection, isolation and purification of Clostridium difficile toxin A with toxin receptorsen
dc.typePatenten
dc.type.dcmitypeTexten
dc.type.patenttypeutilityen
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