Parameter Estimation for a Mathematical Model of the Cell Cycle in Frog Eggs

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dc.contributor.authorZwolak, Jason W.en
dc.contributor.authorTyson, John J.en
dc.contributor.authorWatson, Layne T.en
dc.contributor.departmentComputer Scienceen
dc.date.accessioned2013-06-19T14:37:05Zen
dc.date.available2013-06-19T14:37:05Zen
dc.date.issued2002-08-01en
dc.description.abstractParameter values for a kinetic model of teh nuclear replication-division cycle in frog eggs are estimated by fitting solutions of the kinetic equations (nonlinear ordinary differential equations) to a suite of experimental observations. A set of optimal parameter values is found by minimizing an objective function defined as the orthodonal distance between the data and the model. The differential equations are solved by LSODAR and the objective function is minimized by ODRPACK. The optimal parameter values are close to the "guesstimates" of the modelers who first studied this problem. These tools are sufficiently general to attack more complicated problems, where guesstimation is impractical or unreliable.en
dc.format.mimetypeapplication/postscripten
dc.identifierhttp://eprints.cs.vt.edu/archive/00000605/en
dc.identifier.sourceurlhttp://eprints.cs.vt.edu/archive/00000605/01/ccmJCB02.psen
dc.identifier.trnumberTR-02-18en
dc.identifier.urihttp://hdl.handle.net/10919/20080en
dc.language.isoenen
dc.publisherDepartment of Computer Science, Virginia Polytechnic Institute & State Universityen
dc.relation.ispartofComputer Science Technical Reportsen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectParallel computationen
dc.titleParameter Estimation for a Mathematical Model of the Cell Cycle in Frog Eggsen
dc.typeTechnical reporten
dc.type.dcmitypeTexten

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