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Therapeutic target for protozoal diseases

dc.contributor.assigneeVirginia Tech Intellectual Properties, Inc.en
dc.contributor.inventorRathore, Dharmendaren
dc.contributor.inventorJani, Dewalen
dc.contributor.inventorNagarkatti, Ranaen
dc.date.accessed2016-08-19en
dc.date.accessioned2016-08-24T17:54:47Zen
dc.date.available2016-08-24T17:54:47Zen
dc.date.filed2005-10-14en
dc.date.issued2008-10-21en
dc.description.abstractA novel Fasciclin Related Adhesive Protein (FRAP) from Plasmodium and related parasites is provided as a target for therapeutic intervention in diseases caused by the parasites. FRAP has been shown to play a critical role in adhesion to, or invasion into, host cells by the parasite. Furthermore, FRAP catalyzes the neutralization of heme by the parasite, by promoting its polymerization into hemozoin. This invention provides methods and compositions for therapies based on the administration of protein, DNA or cell-based vaccines and/or antibodies based on FRAP, or antigenic epitopes of FRAP, either alone or in combination with other parasite antigens. Methods for the development of compounds that inhibit the catalytic activity of FRAP, and diagnostic and laboratory methods utilizing FRAP are also provided.en
dc.format.mimetypeapplication/pdfen
dc.identifier.applicationnumber11249355en
dc.identifier.patentnumber7438916en
dc.identifier.urihttp://hdl.handle.net/10919/72592en
dc.identifier.urlhttp://pimg-fpiw.uspto.gov/fdd/16/389/074/0.pdfen
dc.language.isoen_USen
dc.publisherUnited States Patent and Trademark Officeen
dc.subject.cpcA61K39/00en
dc.subject.cpcA61K2039/505en
dc.subject.cpcA61K2039/522en
dc.subject.cpcA61K2039/53en
dc.subject.cpcC07K14/445en
dc.subject.cpcG01N33/56905en
dc.subject.cpcG01N2333/445en
dc.subject.uspc424/191.1en
dc.subject.uspcother424/185.1en
dc.subject.uspcother424/265.1en
dc.subject.uspcother424/268.1en
dc.subject.uspcother424/272.1en
dc.subject.uspcother435/69.1en
dc.subject.uspcother435/69.3en
dc.subject.uspcother435/320.1en
dc.subject.uspcother435/456en
dc.subject.uspcother530/300en
dc.subject.uspcother530/350en
dc.subject.uspcother536/23.1en
dc.subject.uspcother536/23.7en
dc.titleTherapeutic target for protozoal diseasesen
dc.typePatenten
dc.type.dcmitypeTexten
dc.type.patenttypeutilityen

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