Mitochondrial Dysregulation in Skeletal Muscle from Patients Diagnosed with Alzheimer’s Disease and Sporadic Inclusion Body Myositis

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dc.contributor.authorShabrokh, Elikaen
dc.contributor.authorKavanaugh, Johnen
dc.contributor.authorMcMillan, Ryan P.en
dc.contributor.authorPittman, Joshen
dc.contributor.authorHulver, Matthew W.en
dc.contributor.authorFrisard, Madlyn I.en
dc.contributor.departmentHuman Nutrition, Foods, and Exerciseen
dc.date.accessioned2019-11-13T13:49:26Zen
dc.date.available2019-11-13T13:49:26Zen
dc.date.issued2014-05en
dc.description.abstractMitochondrial dysfunction is implicated in Alzheimer’s disease (AD) and disruption of mitochondrial dynamic pathways has been documented in brains from patients diagnosed with AD; although it is unclear whether other tissues are also affected. Much less is known about the mitochondria in patients diagnosed with sporadic Inclusion Body Myositis (sIBM). The current study examined mitochondrial biology in skeletal muscle from AD and sIBM patients compared to healthy, elderly individuals. Skeletal muscle samples were obtained from the National Disease Research Interchange and mRNA, protein content, and enzyme activity was used to assess mitochondrial parameters. Patients diagnosed with AD or sIBM demonstrated reduced mitofusin 2 and optic atrophy protein 1 protein. AD patients also displayed increased mRNA of superoxide dismutase 2, catalase, and uncoupling protein 3. Amyloid β precursor protein mRNA was higher in sIBM patients only compared to both AD patients and elderly individuals. Both total and phosphorylated AMPK protein content, an upstream regulator of mitochondrial dynamics and biogenesis, were also reduced in sIBM patients. The current study demonstrates a disruption in signaling pathways regulating mitochondrial dynamics in both AD and sIBM patients, although the underlying causes may differ.en
dc.format.extent9 pagesen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationShabrokh, E., et al. (2014) Mitochondrial Dysregulation in Skeletal Muscle from Patients Diagnosed with Alzheimer’s Disease and Sporadic Inclusion Body Myositis. Open Journal of Molecular and Integrative Physiology, 4, 11-19. http://dx.doi.org/10.4236/ojmip.2014.42002en
dc.identifier.doihttps://doi.org/10.4236/ojmip.2014.42002en
dc.identifier.urihttp://hdl.handle.net/10919/95526en
dc.identifier.volume4en
dc.language.isoenen
dc.publisherScientific Research Publishingen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectMitochondrial Dynamicsen
dc.subjectAutophagyen
dc.subjectMitochondrial Biogenesisen
dc.subjectAmyloid Beta Precursor Proteinen
dc.subject5’-AMP-Activated Protein Kinaseen
dc.titleMitochondrial Dysregulation in Skeletal Muscle from Patients Diagnosed with Alzheimer’s Disease and Sporadic Inclusion Body Myositisen
dc.title.serialScientific Researchen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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Destination Area: Adaptive Brain and Behavior (ABB)