Case Report: MRI, Clinical, and Pathological Correlates of Bromethalin Toxicosis in Three Dogs

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dc.contributor.authorMurthy, Vishal D.en
dc.contributor.authorMcLarty, Ehrenen
dc.contributor.authorWoolard, Kevin D.en
dc.contributor.authorParker, Rell L.en
dc.contributor.authorKortz, Greggen
dc.contributor.authorKing, Jamie N.en
dc.contributor.authorPoppenga, Robert H.en
dc.contributor.authorKnipe, Marguerite F.en
dc.contributor.authorDickinson, Peter J.en
dc.date.accessioned2022-06-29T18:15:05Zen
dc.date.available2022-06-29T18:15:05Zen
dc.date.issued2022-04-26en
dc.description.abstractBromethalin toxicosis is an increasingly common clinical presentation in dogs that may be fatal depending on the extent of intoxication. Antemortem diagnosis of bromethalin toxicosis was achieved in three dogs by demonstration of the active metabolite desmethylbromethalin in fat or serum. Magnetic resonance imaging (MRI) findings were consistent with a diffuse leukoencephalopathy with restricted diffusion and prominent involvement of the corticospinal motor tracts on T2-weighted and diffusion-weighted sequences. Imaging findings were confirmed in one non-surviving dog at necropsy. Resolution of MRI abnormalities was demonstrated in one surviving dog that was consistent with the associated resolution of clinical signs. Initial findings in these dogs support further investigation of specific MRI patterns in cases of leukoencephalopathy to aid differential diagnosis. While antemortem detection of bromethalin and its metabolites confirms exposure, quantitation may be informative as a prognostic biomarker.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3389/fvets.2022.879007en
dc.identifier.eissn2297-1769en
dc.identifier.other879007en
dc.identifier.pmid35558887en
dc.identifier.urihttp://hdl.handle.net/10919/110982en
dc.identifier.volume9en
dc.language.isoenen
dc.publisherFrontiersen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectbiopsyen
dc.subjectbromethalinen
dc.subjectcanineen
dc.subjectcorticospinal tracten
dc.subjectdesmethylbromethalinen
dc.subjectleukoencephalopathyen
dc.subjectrestricted diffusionen
dc.titleCase Report: MRI, Clinical, and Pathological Correlates of Bromethalin Toxicosis in Three Dogsen
dc.title.serialFrontiers in Veterinary Scienceen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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