Nhlh2 is a Cold-Responsive Gene

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dc.contributor.authorVella, Kristen R.en
dc.contributor.authorGood, Deborah J.en
dc.contributor.departmentHuman Nutrition, Foods, and Exerciseen
dc.date.accessioned2019-11-13T13:49:25Zen
dc.date.available2019-11-13T13:49:25Zen
dc.date.issued2010en
dc.description.abstractNescient helix-loop-helix 2 (Nhlh2) is a basic helix-loop-helix transcription factor that functions to communicate signals of energy availability. Based on the expression pattern of Nhlh2 in cold-sensitive areas of the hypothalamus, we hypothesized that mice containing a targeted deletion of Nhlh2 would be unable to maintain body temperature and that Nhlh2 gene expression would vary with cold exposure. Following cold exposure, Nhlh2 mRNA levels are significantly reduced throughout the hypothalamus. Furthermore, mice with a targeted deletion of Nhlh2 (N2KO mice) are unable to maintain body weight at 4oC. This paper attempts to describe these new results as they relate to the ongoing gene regulation that occurs in the hypothalamus following changes in energy availability brought about by food intake or cold exposure.en
dc.description.sponsorshipThis work was supported by funding from the NIH: R01 DK59903 (to DJG) and T32 MH47538 (to KRV).en
dc.format.extent7 pagesen
dc.format.mimetypeapplication/pdfen
dc.identifier.urihttp://hdl.handle.net/10919/95523en
dc.identifier.volume3en
dc.language.isoenen
dc.publisherBentham Openen
dc.rightsCreative Commons Attribution-NonCommercial 3.0 Unporteden
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/en
dc.subjectNSCL-2en
dc.subjectHen2en
dc.subjecthypothalamusen
dc.subjectcold exposureen
dc.subjectTRHen
dc.subjecttranscription factorsen
dc.subjectgene regulationen
dc.titleNhlh2 is a Cold-Responsive Geneen
dc.title.serialThe Open Neuroendocrinology Journalen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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