Associability-modulated loss learning is increased in posttraumatic stress disorder

dc.contributor.authorBrown, Vanessa M.en
dc.contributor.authorZhu, Lushaen
dc.contributor.authorWang, John M.en
dc.contributor.authorFrueh, B. Christopheren
dc.contributor.authorCasas, Brooksen
dc.contributor.authorChiu, Pearl H.en
dc.date.accessioned2018-01-11T13:32:50Zen
dc.date.available2018-01-11T13:32:50Zen
dc.date.issued2018-01-09en
dc.description.abstractDisproportionate reactions to unexpected stimuli in the environment are a cardinal symptom of posttraumatic stress disorder (PTSD). Here, we test whether these heightened responses are associated with disruptions in distinct components of reinforcement learning. Specifically, using functional neuroimaging, a loss-learning task, and a computational model-based approach, we assessed the mechanistic hypothesis that overreactions to stimuli in PTSD arise from anomalous gating of attention during learning (i.e., associability). Behavioral choices of combat- deployed veterans with and without PTSD were fit to a reinforcement learning model, generating trial-by-trial prediction errors (signaling unexpected outcomes) and associability values (signaling attention allocation to the unexpected outcomes). Neural substrates of associability value and behavioral parameter estimates of associability updating, but not prediction error, increased with PTSD during loss learning. Moreover, the interaction of PTSD severity with neural markers of associability value predicted behavioral choices. These results indicate that increased attention- based learning may underlie aspects of PTSD and suggest potential neuromechanistic treatment targets.en
dc.description.sponsorshipThis work was supported in part by the National Institutes of Health (MH087692, MH106756 to PC), the Department of Veteran Affairs (D7030R to BKC), and the National Natural Science Foundation of China (31671171, 31630034 to LZ). We acknowledge Read Montague and the assistance of Rizwan Ali, George Christopoulos, Dongil Chung, Alec Solway, Jessica Eiseman, Katherine Gardner, David Graham, Jacob Lee, Katherine McCurry, Robert McNamara, Cari Rosoff, Dharol Tankersley, and Wright Williams.en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.7554/eLife.30150.001en
dc.identifier.urihttp://hdl.handle.net/10919/81702en
dc.identifier.volume7en
dc.language.isoenen
dc.publishereLife Sciencesen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.titleAssociability-modulated loss learning is increased in posttraumatic stress disorderen
dc.title.serialeLifeen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

Files

Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
BrownPTSD2018.pdf
Size:
2.78 MB
Format:
Adobe Portable Document Format
License bundle
Now showing 1 - 1 of 1
Name:
license.txt
Size:
1.5 KB
Format:
Item-specific license agreed upon to submission
Description: