Expression Divergence of Tandemly Arrayed Genes in Human and Mouse

Shoja, Valia; Murali, T. M.; Zhang, Liqing

Expression Divergence of Tandemly Arrayed Genes in Human and Mouse

dc.contributor.author	Shoja, Valia	en
dc.contributor.author	Murali, T. M.	en
dc.contributor.author	Zhang, Liqing	en
dc.contributor.department	Computer Science	en
dc.date.accessioned	2017-09-18T10:05:44Z	en
dc.date.available	2017-09-18T10:05:44Z	en
dc.date.issued	2007-10-30	en
dc.date.updated	2017-09-18T10:05:44Z	en
dc.description.abstract	Tandemly arrayed genes (TAGs) account for about one third of the duplicated genes in eukaryotic genomes, yet there has not been any systematic study of their gene expression patterns. Taking advantage of recently published large-scale microarray data sets, we studied the expression divergence of 361 two-member TAGs in human and 212 two-member TAGs in mouse and examined the effect of sequence divergence, gene orientation, and chromosomal proximity on the divergence of TAG expression patterns. Our results show that there is a weak negative correlation between sequence divergence of TAG members and their expression similarity. There is also a weak negative correlation between chromosomal proximity of TAG members and their expression similarity. We did not detect any significant relationship between gene orientation and expression similarity. We also found that downstream TAG members do not show significantly narrower expression breadth than upstream members, contrary to what we predict based on TAG expression divergence hypothesis that we propose. Finally, we show that both chromosomal proximity and expression correlation in TAGs do not differ significantly from their neighboring non-TAG gene pairs, suggesting that tandem duplication is unlikely to be the cause for the higher-than-random expression association between neighboring genes on a chromosome in human and mouse.	en
dc.description.version	Published version	en
dc.format.mimetype	application/pdf	en
dc.identifier.citation	Valia Shoja, T. M. Murali, and Liqing Zhang, “Expression Divergence of Tandemly Arrayed Genes in Human and Mouse,” Comparative and Functional Genomics, vol. 2007, Article ID 60964, 8 pages, 2007. doi:10.1155/2007/60964	en
dc.identifier.doi	https://doi.org/10.1155/2007/60964	en
dc.identifier.uri	http://hdl.handle.net/10919/79077	en
dc.language.iso	en	en
dc.publisher	Hindawi	en
dc.rights	Creative Commons Attribution 4.0 International	en
dc.rights.holder	Copyright © 2007 Valia Shoja et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.	en
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	en
dc.title	Expression Divergence of Tandemly Arrayed Genes in Human and Mouse	en
dc.title.serial	Comparative and Functional Genomics	en
dc.type	Article - Refereed	en
dc.type.dcmitype	Text	en