An emerging cyberinfrastructure for biodefense pathogen and pathogen-host data

Simple item page
dc.contributor.authorZhang, C.en
dc.contributor.authorCrasta, O.en
dc.contributor.authorCammer, S.en
dc.contributor.authorWill, R.en
dc.contributor.authorKenyon, R.en
dc.contributor.authorSullivan, D.en
dc.contributor.authorYu, Q.en
dc.contributor.authorSun, W.en
dc.contributor.authorJha, R.en
dc.contributor.authorLiu, D.en
dc.contributor.authorXue, T.en
dc.contributor.authorZhang, Y.en
dc.contributor.authorMoore, M.en
dc.contributor.authorMcGarvey, P.en
dc.contributor.authorHuang, H.en
dc.contributor.authorChen, Y.en
dc.contributor.authorZhang, J.en
dc.contributor.authorMazumder, R.en
dc.contributor.authorWu, C.en
dc.contributor.authorSobral, Brunoen
dc.date.accessioned2019-04-18T14:46:57Zen
dc.date.available2019-04-18T14:46:57Zen
dc.date.issued2008-01en
dc.description.abstractThe NIAID-funded Biodefense Proteomics Resource Center (RC) provides storage, dissemination, visualization and analysis capabilities for the experimental data deposited by seven Proteomics Research Centers (PRCs). The data and its publication is to support researchers working to discover candidates for the next generation of vaccines, therapeutics and diagnostics against NIAIDs Category A, B and C priority pathogens. The data includes transcriptional profiles, protein profiles, protein structural data and hostpathogen protein interactions, in the context of the pathogen life cycle in vivo and in vitro. The database has stored and supported host or pathogen data derived from Bacillus, Brucella, Cryptosporidium, Salmonella, SARS, Toxoplasma, Vibrio and Yersinia, human tissue libraries, and mouse macrophages. These publicly available data cover diverse data types such as mass spectrometry, yeast two-hybrid (Y2H), gene expression profiles, X-ray and NMR determined protein structures and protein expression clones. The growing database covers over 23 000 unique genes/proteins from different experiments and organisms. All of the genes/proteins are annotated and integrated across experiments using UniProt Knowledgebase (UniProtKB) accession numbers. The web-interface for the database enables searching, querying and downloading at the level of experiment, group and individual gene(s)/protein(s) via UniProtKB accession numbers or protein function keywords. The system is accessible at http://www.proteomicsresource.org/.en
dc.description.sponsorshipNIAID NIH HHS [HHSN266200400061C]; PHS HHS [HHSN266200400061C]en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1093/nar/gkm903en
dc.identifier.eissn1362-4962en
dc.identifier.issn0305-1048en
dc.identifier.pmid17984082en
dc.identifier.urihttp://hdl.handle.net/10919/89034en
dc.identifier.volume36en
dc.language.isoen_USen
dc.rightsCreative Commons Attribution-NonCommercial 2.0 Genericen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/2.0/en
dc.subjectrespiratory syndrome coronavirusen
dc.subjectmagnetic-resonance structureen
dc.subjectsystems biologyen
dc.subjectbacillus-anthracisen
dc.subjectcrystal-structureen
dc.subjectdata resourcesen
dc.subjectomics dataen
dc.subjectproteinen
dc.subjectinformationen
dc.subjectproteomicsen
dc.titleAn emerging cyberinfrastructure for biodefense pathogen and pathogen-host dataen
dc.title.serialNucleic Acids Researchen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
gkm903.pdf
Size:
5.94 MB
Format:
Adobe Portable Document Format
Description:
Download

Collections

Scholarly Works, Fralin Life Sciences Institute