Usefulness of neutrophil-to-lymphocyte ratio (NLR) as a prognostic predictor after treatment of hepatocellular carcinoma

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dc.contributor.authorMouchli, Mohamaden
dc.contributor.authorShravani, Reddyen
dc.contributor.authorGerrard, Mirandaen
dc.contributor.authorBoardman, Lisaen
dc.contributor.authorRubio, Marriethen
dc.contributor.departmentVirginia Tech Carilion School of Medicineen
dc.date.accessioned2021-07-28T18:14:03Zen
dc.date.available2021-07-28T18:14:03Zen
dc.date.issued2021-05en
dc.description.abstractThe neutrophil-to-lymphocyte ratio (NLR) is an inflammatory marker which has been investigated as a prognostic indicator in post-therapeutic recurrence and survival of patients with HCC. Our aim was to review all studies that assessed the prognostic value of pre-treatment NLR in predicting patient survival, cancer recurrence, and graft survival in patients undergoing various therapies for HCC. We searched the database of PubMed and Google Scholar to review all studies that have the word "NLR" and the word "HCC." We included all studies that assessed pre-treatment NLR as a prognostic factor in predicting outcomes in HCC patients. We excluded studies that assessed the correlation between post-treatment NLR or dynamic changes in NLR after treatment and HCC outcomes in an effort to minimize the confounding effect of each treatment on NLR. We reviewed 123 studies that studied the correlation between pretreatment NLR and patient survival, 72 studies that evaluated the correlation between pre-treatment NLR and tumor recurrence, 21 studies that evaluated the correlation between NLR and tumor behavior, and 4 studies that assessed the correlation between NLR and graft survival. We found a remarkable heterogeneity between the methods of the studies, which is likely responsible for the differences in outcomes. The majority of the studies suggested a correlation between higher levels of pre-treatment NLR and poor outcomes. We concluded that NLR is a reliable and inexpensive biomarker and should be incorporated into other prognostic models to help determine outcomes following HCC treatment. (C) 2020 Fundacion Clinica Medica Sur, A.C. Published by Elsevier Espana, S.L.U.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1016/j.aohep.2020.08.067en
dc.identifier.issn1665-2681en
dc.identifier.other100249en
dc.identifier.pmid32896610en
dc.identifier.urihttp://hdl.handle.net/10919/104430en
dc.identifier.volume22en
dc.language.isoenen
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectNLRen
dc.subjectHCC outcomesen
dc.subjectLTen
dc.subjectResectionen
dc.subjectChemotherapy and other therapiesen
dc.titleUsefulness of neutrophil-to-lymphocyte ratio (NLR) as a prognostic predictor after treatment of hepatocellular carcinomaen
dc.title.serialAnnals of Hepatologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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