Measurement of preprandial and postprandial urine calcium to creatinine ratios in male Miniature Schnauzers with and without urolithiasis

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dc.contributor.authorCarr, Susan V.en
dc.contributor.authorGrant, David C.en
dc.contributor.authorDeMonaco, Stefanie M.en
dc.contributor.authorShepherd, Megan L.en
dc.date.accessioned2020-05-26T16:21:59Zen
dc.date.available2020-05-26T16:21:59Zen
dc.date.issued2020-03en
dc.description.abstractBackground We aimed to identify a simple test for excessive calciuresis and predict calcium oxalate (CaOx) disease in Miniature Schnauzers. We investigated the impact of postprandial time on the urine calcium to creatinine ratio (UCa/Cr) in male dogs of this breed, with the goal of improving the utility of the UCa/Cr. Hypotheses (1) Significant differences will exist in preprandial and postprandial UCa/Cr between CaOx urolith-forming and control Schnauzers. (2) The UCa/Cr will increase significantly from the first morning baseline at >= 1 postprandial time point(s) in both control and CaOx urolith-forming dogs. (3) Biochemical abnormalities and other variables may be associated with urolith status. Animals Twenty-four male Miniature Schnauzer dogs, consisting of 9 with (urolith formers) and 15 without (controls) CaOx uroliths. Methods Urine was collected before and 1, 2, 4, and 8 hours after feeding a standardized diet. Receiver operator characteristic curve analysis was performed to identify the UCa/Cr cutoff that most accurately differentiates dogs based on urolith status. Results Urolith formers had significantly higher mean UCa/Cr over the course of 8 hours. The postprandial change in UCa/Cr was not significant at any time point between or within groups. The cutoff UCa/Cr value of 0.06 had a specificity of 93% (95% confidence interval [CI], 80%-100%) and a sensitivity of 56% (95% CI, 21%-86%) for identifying CaOx urolithiasis. Conclusions and Clinical Importance Urolith-forming male Miniature Schnauzers have excessive calciuresis, and the postprandial sampling time up to 8 hours is not critical. This simple urine measurement has potential as a marker of CaOx disease.en
dc.description.notesMorris Animal Foundation, Grant/Award Number: D17CA-841en
dc.description.sponsorshipMorris Animal Foundation [D17CA-841]en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1111/jvim.15690en
dc.identifier.eissn1939-1676en
dc.identifier.issn0891-6640en
dc.identifier.issue2en
dc.identifier.pmid31926039en
dc.identifier.urihttp://hdl.handle.net/10919/98551en
dc.identifier.volume34en
dc.language.isoenen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectcalciuresisen
dc.subjectcystolithiasisen
dc.subjectnephrolithiasisen
dc.subjectveterinaryen
dc.titleMeasurement of preprandial and postprandial urine calcium to creatinine ratios in male Miniature Schnauzers with and without urolithiasisen
dc.title.serialJournal of Veterinary Internal Medicineen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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