XTALKDB: a database of signaling pathway crosstalk

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dc.contributor.authorSam, Sarah A.en
dc.contributor.authorTeel, Joelleen
dc.contributor.authorTegge, Allison N.en
dc.contributor.authorBharadwaj, Adityaen
dc.contributor.authorMurali, T. M.en
dc.contributor.departmentBiological Sciencesen
dc.contributor.departmentComputer Scienceen
dc.contributor.departmentStatisticsen
dc.contributor.departmentInstitute for Critical Technology and Applied Scienceen
dc.date.accessioned2019-04-11T18:07:53Zen
dc.date.available2019-04-11T18:07:53Zen
dc.date.issued2017-01-04en
dc.description.abstractAnalysis of signaling pathways and their crosstalk is a cornerstone of systems biology. Thousands of papers have been published on these topics. Surprisingly, there is no database that carefully and explicitly documents crosstalk between specific pairs of signaling pathways. We have developed XTALKDB (http://www.xtalkdb.org) to fill this very important gap. XTALKDB contains curated information for 650 pairs of pathways from over 1600 publications. In addition, the database reports the molecular components (e.g. proteins, hormones, microRNAs) that mediate crosstalk between a pair of pathways and the species and tissue in which the crosstalk was observed. The XTALKDB website provides an easy-to- use interface for scientists to browse crosstalk information by querying one or more pathways or molecules of interest.en
dc.description.notesEnvironmental Protection Agency [EPA-RD-83499801 to T.M.M.]; National Science Foundation [DBI-1062380 to T.M.M.]; National Institute of General Medical Sciences of the National Institutes of Health [GM095955 to T.M.M.]; National Research Service Award [F32-ES024062 to A.N.T.]; National Institutes of Health Traineeship [GM072767-09 to S.A.S.].en
dc.description.sponsorshipEnvironmental Protection Agency [EPA-RD-83499801]; National Science Foundation [DBI-1062380]; National Institute of General Medical Sciences of the National Institutes of Health [GM095955]; National Research Service Award [F32-ES024062]; National Institutes of Health Traineeship [GM072767-09]en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1093/nar/gkw1037en
dc.identifier.eissn1362-4962en
dc.identifier.issn0305-1048en
dc.identifier.issueD1en
dc.identifier.pmid27899583en
dc.identifier.urihttp://hdl.handle.net/10919/88887en
dc.identifier.volume45en
dc.language.isoen_USen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectnotchen
dc.subjectnetworksen
dc.subjectcanceren
dc.subjectresourceen
dc.subjecthedgehogen
dc.subjectannotationen
dc.subjectupdateen
dc.titleXTALKDB: a database of signaling pathway crosstalken
dc.title.serialNucleic Acids Researchen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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