MRI brain templates of the male Yucatan minipig
| dc.contributor.author | Norris, Carly | en |
| dc.contributor.author | Lisinski, Jonathan | en |
| dc.contributor.author | McNeil, Elizabeth M. | en |
| dc.contributor.author | VanMeter, John W. | en |
| dc.contributor.author | VandeVord, Pamela J. | en |
| dc.contributor.author | LaConte, Stephen M. | en |
| dc.contributor.department | Biomedical Engineering and Mechanics | en |
| dc.contributor.department | Fralin Biomedical Research Institute | en |
| dc.date.accessioned | 2021-04-16T12:45:40Z | en |
| dc.date.available | 2021-04-16T12:45:40Z | en |
| dc.date.issued | 2021-07-15 | en |
| dc.description.abstract | The pig is growing in popularity as an experimental animal because its gyrencephalic brain is similar to humans. Currently, however, there is a lack of appropriate brain templates to support functional and structural neuroimaging pipelines. The primary contribution of this work is an average volume from an iterative, non-linear registration of 70 five- to seven-month-old male Yucatan minipigs. In addition, several aspects of this study are unique, including the comparison of linear and non-linear template generation, the characterization of a large and homogeneous cohort, an analysis of effective resolution after averaging, and the evaluation of potential in-template bias as well as a comparison with a template from another minipig species using a “left-out” validation set. We found that within our highly homogeneous cohort, non-linear registration produced better templates, but only marginally so. Although our T1-weighted data were resolution limited, we preserved effective resolution across the multi-subject average, produced templates that have high gray-white matter contrast and demonstrate superior registration accuracy compared to an alternative minipig template. | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.doi | https://doi.org/10.1016/j.neuroimage.2021.118015 | en |
| dc.identifier.uri | http://hdl.handle.net/10919/103039 | en |
| dc.identifier.volume | 235 | en |
| dc.language.iso | en | en |
| dc.publisher | Elsevier | en |
| dc.rights | Attribution 4.0 International | en |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en |
| dc.subject | MRI | en |
| dc.subject | Yucatan | en |
| dc.subject | Brain | en |
| dc.subject | Template | en |
| dc.subject | AFNI | en |
| dc.title | MRI brain templates of the male Yucatan minipig | en |
| dc.title.serial | NeuroImage | en |
| dc.type | Article - Refereed | en |