Analysis of horse genomes provides insight into the diversification and adaptive evolution of karyotype

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dc.contributorVirginia Techen
dc.contributor.authorHuang, J. L.en
dc.contributor.authorZhao, Y. P.en
dc.contributor.authorShiraigol, W.en
dc.contributor.authorLi, B.en
dc.contributor.authorBai, D. Y.en
dc.contributor.authorYe, W. X.en
dc.contributor.authorDaidiikhuu, D.en
dc.contributor.authorYang, L. H.en
dc.contributor.authorJin, Brqqgen
dc.contributor.authorZhao, Q. A.en
dc.contributor.authorGao, Y. H.en
dc.contributor.authorWu, J.en
dc.contributor.authorBao, Wydlen
dc.contributor.authorLi, A. A.en
dc.contributor.authorZhang, Y. H. Percivalen
dc.contributor.authorHan, H. G.en
dc.contributor.authorBai, H. T.en
dc.contributor.authorBao, Y. Q.en
dc.contributor.authorZhao, L. L.en
dc.contributor.authorZhai, Z. X.en
dc.contributor.authorZhao, W. J.en
dc.contributor.authorSun, Z. K.en
dc.contributor.authorZhang, Y.en
dc.contributor.authorMeng, H.en
dc.contributor.authorDugarjaviin, M.en
dc.date.accessed2014-06-13en
dc.date.accessioned2014-06-16T14:11:25Zen
dc.date.available2014-06-16T14:11:25Zen
dc.date.issued2014-05en
dc.description.abstractKaryotypic diversification is more prominent in Equus species than in other mammals. Here, using next generation sequencing technology, we generated and de novo assembled quality genomes sequences for a male wild horse (Przewalski's horse) and a male domestic horse (Mongolian horse), with about 93-fold and 91-fold coverage, respectively. Portion of Y chromosome from wild horse assemblies (3 M bp) and Mongolian horse (2 M bp) were also sequenced and de novo assembled. We confirmed a Robertsonian translocation event through the wild horse's chromosomes 23 and 24, which contained sequences that were highly homologous with those on the domestic horse's chromosome 5. The four main types of rearrangement, insertion of unknown origin, inserted duplication, inversion, and relocation, are not evenly distributed on all the chromosomes, and some chromosomes, such as the X chromosome, contain more rearrangements than others, and the number of inversions is far less than the number of insertions and relocations in the horse genome. Furthermore, we discovered the percentages of LINE_L1 and LTR_ERV1 are significantly increased in rearrangement regions. The analysis results of the two representative Equus species genomes improved our knowledge of Equus chromosome rearrangement and karyotype evolution.en
dc.description.sponsorshipMinistry of Science and Technology of the People's Republic of China specific scientific and technological cooperation with Russia 2011DFR30860en
dc.description.sponsorshipInner Mongolia major scientific and technological projects NK-20120395en
dc.description.sponsorshipNational Natural Science Foundation of China 31360538, 31160446en
dc.description.sponsorshipInner Mongolia key laboratory project 20130902en
dc.description.sponsorshipInner Mongolia Agricultural University Equine Science and Industrialization Innovation Team Support Program NDTD2010-12en
dc.description.sponsorshipMinistry of Agriculture of the People's Republic of China public welfare specific scientific and technological projects 201003075en
dc.identifier.citationHuang, J. L.; Zhao, Y. P.; et al., "Analysis of horse genomes provides insight into the diversification and adaptive evolution of karyotype," Scientific Reports 4:4958, (2014). DOI: 10.1038/srep04958.en
dc.identifier.doihttps://doi.org/10.1038/srep04958en
dc.identifier.issn2045-2322en
dc.identifier.urihttp://hdl.handle.net/10919/48933en
dc.identifier.urlhttp://www.nature.com/srep/2014/140514/srep04958/full/srep04958.htmlen
dc.language.isoen_USen
dc.publisherNature Publishing Groupen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectequus-caballusen
dc.subjectchromosome complementen
dc.subjectuniparental disomyen
dc.subjectdomesticen
dc.subjectHorsesen
dc.subjecte-przewalskiien
dc.subjectsequenceen
dc.subjectspeciationen
dc.subjectalignmenten
dc.subjectpipelineen
dc.subjectdogen
dc.subjectmultidisciplinary sciencesen
dc.titleAnalysis of horse genomes provides insight into the diversification and adaptive evolution of karyotypeen
dc.title.serialScientific Reportsen
dc.typeArticle - Refereeden

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