Randomized Manipulation of Early Cognitive Experience Impacts Adult Brain Structure

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dc.contributor.authorFarah, Martha J.en
dc.contributor.authorSternberg, Saulen
dc.contributor.authorNichols, Thomas A.en
dc.contributor.authorDuda, Jeffrey T.en
dc.contributor.authorLohrenz, Terryen
dc.contributor.authorLuo, Yien
dc.contributor.authorSonnier, Libbieen
dc.contributor.authorRamey, Sharon L.en
dc.contributor.authorMontague, P. Readen
dc.contributor.authorRamey, Craig T.en
dc.contributor.departmentFralin Biomedical Research Instituteen
dc.date.accessioned2021-06-01T13:32:32Zen
dc.date.available2021-06-01T13:32:32Zen
dc.date.issued2021en
dc.description.abstractDoes early exposure to cognitive and linguistic stimulation impact brain structure? Or do genetic predispositions account for the co-occurrence of certain neuroanatomical phenotypes and a tendency to engage children in cognitively stimulating activities? Low socioeconomic status infants were randomized to either 5 years of cognitively and linguistically stimulating center-based care or a comparison condition. The intervention resulted in large and statistically significant changes in brain structure measured in midlife, particularly for male individuals. These findings are the first to extend the large literature on cognitive enrichment effects on animal brains to humans, and to demonstrate the effects of uniquely human features such as linguistic stimulation.en
dc.description.sponsorshipThis work was supported by a Principal Research Fellowship from the Wellcome Trust (R. M.), Virginia Tech (R. M.) and the School of Arts and Sciences Research Fund, University of Pennsylvania (M. J. F.).en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1162/jocn_a_01709en
dc.identifier.issue6en
dc.identifier.urihttp://hdl.handle.net/10919/103551en
dc.identifier.volume33en
dc.language.isoenen
dc.publisherMassachusetts Institute of Technologyen
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleRandomized Manipulation of Early Cognitive Experience Impacts Adult Brain Structureen
dc.title.serialJournal of Cognitive Neuroscienceen
dc.typeArticle - Refereeden

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Scholarly Works, Fralin Biomedical Research Institute at VTC
Destination Area: Adaptive Brain and Behavior (ABB)