Bioluminescence Tomography - Inner-light, Insight from Infrared

Bioluminescence tomography (BLT) is a molecular imaging modality, which derives a bioluminescent source distribution inside a small animal from external bioluminescent signals. We published the first paper on BLT in 2004 using the modality fusion approach. The introduction of BLT can be compared to the development of x-ray CT based on radiography. Without BLT, bioluminescent imaging is basically qualitative. With BLT, quantitative and 3D analyses become feasible inside a living mouse, which reveal important molecular and cellular information for numerous preclinical applications. *Complimentary film demonstrates 3D analysis of a living mouse with bioluminescent source