Sub-Second Dopamine Detection in Human Striatum

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dc.contributor.authorKishida, Kenneth T.en
dc.contributor.authorSandberg, Stefan G.en
dc.contributor.authorLohrenz, Terryen
dc.contributor.authorComair, Youssef G.en
dc.contributor.authorSáez, Ignacioen
dc.contributor.authorPhillips, Paul E. M.en
dc.contributor.authorMontague, P. Readen
dc.date.accessioned2017-09-08T14:18:50Zen
dc.date.available2017-09-08T14:18:50Zen
dc.date.issued2011-08-04en
dc.description.abstractFast-scan cyclic voltammetry at carbon fiber microelectrodes allows rapid (sub-second) measurements of dopamine release in behaving animals. Herein, we report the modification of existing technology and demonstrate the feasibility of making sub-second measurements of dopamine release in the caudate nucleus of a human subject during brain surgery. First, we describe the modification of our electrodes that allow for measurements to be made in a human brain. Next, we demonstrate in vitro and in vivo, that our modified electrodes can measure stimulated dopamine release in a rat brain equivalently to previously determined rodent electrodes. Finally, we demonstrate acute measurements of dopamine release in the caudate of a human patient during DBS electrode implantation surgery. The data generated are highly amenable for future work investigating the relationship between dopamine levels and important decision variables in human decisionmaking tasks.en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0023291en
dc.identifier.issue8en
dc.identifier.urihttp://hdl.handle.net/10919/78842en
dc.identifier.volume6en
dc.language.isoen_USen
dc.publisherPLOSen
dc.rightsCreative Commons CC0 1.0 Universal Public Domain Dedicationen
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/en
dc.titleSub-Second Dopamine Detection in Human Striatumen
dc.title.serialPLOS ONEen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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Destination Area: Adaptive Brain and Behavior (ABB)
Scholarly Works, Fralin Biomedical Research Institute at VTC