Network Effects of Risk Behavior Change Following Prophylactic Interventions

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dc.contributor.authorRajaraman, Rajmohanen
dc.contributor.authorSun, Zhifengen
dc.contributor.authorSundaram, Ravien
dc.contributor.authorVullikanti, Anil Kumar S.en
dc.contributor.departmentComputer Scienceen
dc.contributor.departmentFralin Life Sciences Instituteen
dc.date.accessioned2018-10-18T16:58:14Zen
dc.date.available2018-10-18T16:58:14Zen
dc.date.issued2013-08-01en
dc.description.abstractWe formulated a network-based model to understand how risk behavior change in conjunction with failure of prophylactic interventions can lead to unintended outcomes where “less (intervention) is more (effective).” Our model captures the distinction between one- and two-sided risk behavior change. In one-sided situations (e.g. influenza/H1N1) it is sufficient for either individual in an interaction to exhibit risk behavior change whereas in two-sided situations (e.g. AIDS/HIV) it is necessary for both individuals in the interaction to exhibit risk behavior change, for a potential transmission of the disease. A central discovery is that this phenomenon occurs at differing levels of intervention coverage depending upon the “sidedness” of the interaction. We find that for one-sided interactions, sufficiently high vaccination coverage is necessary for mitigating the effects of risk behavior; for two-sided interactions, it is essential to combine prophylactic treatments with programs aimed at reducing risky behavior. Furthermore, again dependent on the “sidedness,” targeting highly connected nodes can be strictly worse than uniformly random interventions at the same level of coverage.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0064653en
dc.identifier.eissn1932-6203en
dc.identifier.issue8en
dc.identifier.othere64653en
dc.identifier.pmid23936290en
dc.identifier.urihttp://hdl.handle.net/10919/85412en
dc.identifier.volume8en
dc.language.isoenen
dc.publisherPLOSen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleNetwork Effects of Risk Behavior Change Following Prophylactic Interventionsen
dc.title.serialPLOS ONEen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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