Toll-Interacting Protein in Resolving and Non-Resolving Inflammation

Simple item page
dc.contributor.authorKowalski, Elizabeth A.en
dc.contributor.authorLi, Liwuen
dc.contributor.departmentBiological Sciencesen
dc.date.accessioned2019-08-29T12:25:41Zen
dc.date.available2019-08-29T12:25:41Zen
dc.date.issued2017-05-05en
dc.description.abstractInnate leukocytes manifest dynamic and distinct inflammatory responses upon challenges with rising dosages of pathogen-associated molecular pattern molecules such as lipopolysaccharide (LPS). To differentiate signal strengths, innate leukocytes may utilize distinct intracellular signaling circuitries modulated by adaptor molecules. Toll-interacting protein (Tollip) is one of the critical adaptor molecules potentially playing key roles in modulating the dynamic adaptation of innate leukocytes to varying dosages of external stimulants. While Tollip may serve as a negative regulator of nuclear factor κ of activated B cells signaling pathway in cells challenged with higher dosages of LPS, it acts as a positive regulator for low-grade chronic inflammation in leukocytes programmed by subclinical low-dosages of LPS. This review aims to discuss recent progress in our understanding of complex innate leukocyte dynamics and its relevance in the pathogenesis of resolving versus non-resolving chronic inflammatory diseases.en
dc.format.extent6 pagesen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationKowalski EJA and Li L (2017) Toll-Interacting Protein in Resolving and Non-Resolving Inflammation. Front. Immunol. 8:511. doi: 10.3389/fimmu.2017.00511en
dc.identifier.doihttps://doi.org/10.3389/fimmu.2017.00511en
dc.identifier.urihttp://hdl.handle.net/10919/93291en
dc.identifier.volume8en
dc.language.isoenen
dc.publisherFrontiersen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectlow-grade inflammationen
dc.subjecttoll-like receptor 4en
dc.subjecttoll-interacting proteinen
dc.subjectlipopolysaccharideen
dc.subjectlysosome fusionen
dc.subjectmitochondriaen
dc.titleToll-Interacting Protein in Resolving and Non-Resolving Inflammationen
dc.title.serialFrontiers in Immunologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
fimmu-08-00511.pdf
Size:
604.43 KB
Format:
Adobe Portable Document Format
Description:
Download

Collections

Scholarly Works, Biological Sciences