The Ionotropic Receptors IR21a and IR25a mediate cool sensing in Drosophila

dc.contributor.authorNi, Linaen
dc.contributor.authorKlein, Masonen
dc.contributor.authorSvec, Kathryn V.en
dc.contributor.authorBudelli, Gonzaloen
dc.contributor.authorChang, Elaine C.en
dc.contributor.authorFerrer, Anggie J.en
dc.contributor.authorBenton, Richarden
dc.contributor.authorSamuel, Aravinthan D. T.en
dc.contributor.authorGarrity, Paul A.en
dc.contributor.departmentSchool of Neuroscienceen
dc.date.accessioned2019-02-22T14:23:37Zen
dc.date.available2019-02-22T14:23:37Zen
dc.date.issued2016-04-29en
dc.description.abstractAnimals rely on highly sensitive thermoreceptors to seek out optimal temperatures, but the molecular mechanisms of thermosensing are not well understood. The Dorsal Organ Cool Cells (DOCCs) of the Drosophila larva are a set of exceptionally thermosensitive neurons critical for larval cool avoidance. Here, we show that DOCC cool-sensing is mediated by Ionotropic Receptors (IRs), a family of sensory receptors widely studied in invertebrate chemical sensing. We find that two IRs, IR21a and IR25a, are required to mediate DOCC responses to cooling and are required for cool avoidance behavior. Furthermore, we find that ectopic expression of IR21a can confer coolresponsiveness in an Ir25a-dependent manner, suggesting an instructive role for IR21a in thermosensing. Together, these data show that IR family receptors can function together to mediate thermosensation of exquisite sensitivity.en
dc.description.sponsorshipNational Institute of Neurological Disorders and Stroke: F32 NS077835en
dc.description.sponsorshipNational Institute of General Medical Sciences: F32 GM113318 and P01 GM103770en
dc.description.sponsorshipEuropean Research Council: 205202 and 615094.en
dc.format.extent12 pagesen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1101/032540en
dc.identifier.urihttp://hdl.handle.net/10919/87737en
dc.identifier.volume5en
dc.language.isoen_USen
dc.publishereLife Sciences Publicationsen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleThe Ionotropic Receptors IR21a and IR25a mediate cool sensing in Drosophilaen
dc.title.serialeLifeen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
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