Rearranged taxol compounds and method of using in testing of in vivo activity

dc.contributor.assigneeVirginia Tech Intellectual Properties, Inc.en
dc.contributor.inventorKingston, David G. I.en
dc.contributor.inventorSamaranayake, Gamini S.en
dc.date.accessed2016-08-19en
dc.date.accessioned2016-08-24T17:55:34Zen
dc.date.available2016-08-24T17:55:34Zen
dc.date.filed1992-02-24en
dc.date.issued1993-03-16en
dc.description.abstractIn a preferred embodiment, taxol is treated with mesyl chloride to prepare a taxol derivative with a contracted A-ring, which has comparable activity to taxol in a tubulin depolymerization assay, and which shows cytotoxicity against KB cells in a cell culture assay. In an alternate preferred embodiment, taxol is treated with triethyloxonium tetrafluoroborate (Meerwein's reagent) to produce a taxol derivative with an opened oxetane ring. In another alternate preferred embodiment, reaction of taxol with acetyl chloride yields a taxol derivative in which the oxetane ring is opened and the A-ring is contracted. All of the aforementioned products show in vivo activity in KB cell culture assays. Further, the preferred compounds have different in vivo activities, which makes them ideal to form a range of standards for use in biological testing of other compounds.en
dc.format.mimetypeapplication/pdfen
dc.identifier.applicationnumber7839082en
dc.identifier.patentnumber5194635en
dc.identifier.urihttp://hdl.handle.net/10919/72798en
dc.identifier.urlhttp://pimg-fpiw.uspto.gov/fdd/35/946/051/0.pdfen
dc.language.isoen_USen
dc.publisherUnited States Patent and Trademark Officeen
dc.subject.cpcC07D317/70en
dc.subject.cpcC07D305/14en
dc.subject.uspc549/430en
dc.subject.uspcother549/510en
dc.titleRearranged taxol compounds and method of using in testing of in vivo activityen
dc.typePatenten
dc.type.dcmitypeTexten
dc.type.patenttypeutilityen

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