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The effects of magnetic nanoparticle properties on magnetic fluid hyperthermia

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dc.contributorVirginia Tech. Engineering Science and Mechanics Departmenten
dc.contributorJadavpur University. Department of Power Engineeringen
dc.contributor.authorKappiyoor, Ravien
dc.contributor.authorLiangruksa, Monrudeeen
dc.contributor.authorGanguly, Ranjanen
dc.contributor.authorPuri, Ishwar K.en
dc.contributor.departmentBiomedical Engineering and Mechanicsen
dc.date.accessed2015-04-24en
dc.date.accessioned2015-06-01T16:10:47Zen
dc.date.available2015-06-01T16:10:47Zen
dc.date.issued2010-11-01en
dc.description.abstractMagnetic fluid hyperthermia (MFH) is a noninvasive treatment that destroys cancer cells by heating a ferrofluid-impregnated malignant tissue with an ac magnetic field while causing minimal damage to the surrounding healthy tissue. The strength of the magnetic field must be sufficient to induce hyperthermia but it is also limited by the human ability to safely withstand it. The ferrofluid material used for hyperthermia should be one that is readily produced and is nontoxic while providing sufficient heating. We examine six materials that have been considered as candidates for MFH use. Examining the heating produced by nanoparticles of these materials, barium-ferrite and cobalt-ferrite are unable to produce sufficient MFH heating, that from iron-cobalt occurs at a far too rapid rate to be safe, while fcc iron-platinum, magnetite, and maghemite are all capable of producing stable controlled heating. We simulate the heating of ferrofluid-loaded tumors containing nanoparticles of the latter three materials to determine their effects on tumor tissue. These materials are viable MFH candidates since they can produce significant heating at the tumor center yet maintain the surrounding healthy tissue interface at a relatively safe temperature. (c) 2010 American Institute of Physics. [doi:10.1063/1.3500337]en
dc.format.extent9 pagesen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationKappiyoor, Ravi, Liangruksa, Monrudee, Ganguly, Ranjan, Puri, Ishwar K. (2010). The effects of magnetic nanoparticle properties on magnetic fluid hyperthermia. Journal of Applied Physics, 108(9). doi: 10.1063/1.3500337en
dc.identifier.doihttps://doi.org/10.1063/1.3500337en
dc.identifier.issn0021-8979en
dc.identifier.urihttp://hdl.handle.net/10919/52886en
dc.identifier.urlhttp://scitation.aip.org/content/aip/journal/jap/108/9/10.1063/1.3500337en
dc.language.isoen_USen
dc.publisherAmerican Institute of Physicsen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectCanceren
dc.subjectTissuesen
dc.subjectNanoparticlesen
dc.subjectMagnetic fieldsen
dc.subjectFerrofluidsen
dc.titleThe effects of magnetic nanoparticle properties on magnetic fluid hyperthermiaen
dc.title.serialJournal of Applied Physicsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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