VTechWorks staff will be away for the Thanksgiving holiday beginning at noon on Wednesday, November 27, through Friday, November 29. We will resume normal operations on Monday, December 2. Thank you for your patience.
 

Alterations in Brain Connectivity Underlying Beta Oscillations in Parkinsonism

Simple item page
dc.contributor.authorMoran, Rosalyn J.en
dc.contributor.authorMallet, Nicolasen
dc.contributor.authorLitvak, Vladimiren
dc.contributor.authorDolan, Raymond J.en
dc.contributor.authorMagill, Peter J.en
dc.contributor.authorFriston, Karl J.en
dc.contributor.authorBrown, Peteren
dc.date.accessioned2019-06-03T21:03:01Zen
dc.date.available2019-06-03T21:03:01Zen
dc.date.issued2011-08-11en
dc.description.abstractCortico-basal ganglia-thalamocortical circuits are severely disrupted by the dopamine depletion of Parkinson’s disease (PD), leading to pathologically exaggerated beta oscillations. Abnormal rhythms, found in several circuit nodes are correlated with movement impairments but their neural basis remains unclear. Here, we used dynamic causal modeling (DCM) and the 6-hydroxydopamine-lesioned rat model of PD to examine the effective connectivity underlying these spectral abnormalities. We acquired auto-spectral and cross-spectral measures of beta oscillations (10–35 Hz) from local field potential recordings made simultaneously in the frontal cortex, striatum, external globus pallidus (GPe) and subthalamic nucleus (STN), and used these data to optimise neurobiologically plausible models. Chronic dopamine depletion reorganised the cortico-basal ganglia-thalamocortical circuit, with increased effective connectivity in the pathway from cortex to STN and decreased connectivity from STN to GPe. Moreover, a contribution analysis of the Parkinsonian circuit distinguished between pathogenic and compensatory processes and revealed how effective connectivity along the indirect pathway acquired a strategic importance that underpins beta oscillations. In modeling excessive beta synchrony in PD, these findings provide a novel perspective on how altered connectivity in basal ganglia-thalamocortical circuits reflects a balance between pathogenesis and compensation, and predicts potential new therapeutic targets to overcome dysfunctional oscillations.en
dc.description.sponsorshipRJM was funded by an Award from the Max Planck Society to RJD. RJD and KJF are funded by the Wellcome Trust. NM, PJM and PB are funded by the Medical Research Council UK, Wellcome Trust, Rosetrees Trust, The Dana Foundation USA and Parkinson’s UK (grant number G-0806).en
dc.format.extent15 pagesen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationMoran RJ, Mallet N, Litvak V, Dolan RJ, Magill PJ, et al. (2011) Alterations in Brain Connectivity Underlying Beta Oscillations in Parkinsonism. PLoS Comput Biol 7(8): e1002124. doi:10.1371/journal.pcbi.1002124en
dc.identifier.doihttps://doi.org/10.1371/journal.pcbi.1002124en
dc.identifier.issue8en
dc.identifier.urihttp://hdl.handle.net/10919/89713en
dc.identifier.volume7en
dc.language.isoenen
dc.publisherPLOSen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleAlterations in Brain Connectivity Underlying Beta Oscillations in Parkinsonismen
dc.title.serialPLOS Computational Biologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
journal.pcbi.1002124.PDF
Size:
1.47 MB
Format:
Adobe Portable Document Format
Download

Collections

Scholarly Works, Fralin Biomedical Research Institute at VTC
Destination Area: Adaptive Brain and Behavior (ABB)